Results 81 to 90 of about 34,300 (180)
The Inclusion Trade‐Off: Comparing the Design and Functionality of Collaborative Governance Forums
Policy Studies Journal, EarlyView.ABSTRACT Environmental challenges require collaboration across jurisdictions, often through forums or intermediary spaces for repeated interaction. A persistent forum design question concerns inclusion criteria, or which actors should be included.
Adam Wiechman +3 more
wiley +1 more source
白细胞介素8和载脂蛋白E基因多态性与迟发性 阿尔茨海默病的相关分析
Zhongshan Daxue xuebao. Yixue kexue ban, 2010 【目的】 探讨白细胞介素8基因(interleukin-8,IL-8)基因A-251T和载脂蛋白E(ApoE)基因多态性与迟发性阿尔茨海默病(LOAD)的相关性65377;【方法】 采用聚合酶链反应-限制性片段长度多态性方法(PCR-RFLP)观察185例广东汉族人群 (研究组:LOAD患者88例,正常对照组97例) IL-8基因A-251T基因65380;ApoE基因多态性的分布并进行关联分析65377;【结果】 ① IL-8 基因A ...
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OPN基因启动区-156delG多态性与中国HBV相关肝细胞癌的易感性
Zhongshan Daxue xuebao. Yixue kexue ban, 2017 【目的】研究骨桥蛋白（OPN）基因启动区多态性与乙型肝炎病毒相关肝细胞癌（HBV-HCC）遗传易感性的关 系。【方法】225例确诊为HBV-HCC患者与200例年龄匹配的慢性乙型肝炎患者被纳入研究。OPN基因启动区3个多态性 位点（-156delG/G ，-443T/C和-616T/G）通过直接测序法确定基因型。【结果】HBV-HCC组-156 delG/delG基因型分布频率高 于对照组（P = 0.003）。HCC组-156 delG等位基因频率显著增高（P < 0.001 ...
时红, 吴元凯, 林国莉, 李向永
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Emotion and the Advocacy Coalition Framework: An Affective Dynamics Perspective
Policy Studies Journal, EarlyView.ABSTRACT Despite extensive evidence that emotion and cognition are deeply intertwined, the Advocacy Coalition Framework (ACF) lacks an analytically independent emotional mechanism in its causal architecture—an omission that may be particularly consequential in policy subsystems structured around morally charged, identity‐laden policy disputes.
Moshe Maor
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2012 肿瘤是一类细胞周期疾病,是多基因长期共同作用的结果。抑癌基因是指能够抑制细胞癌基因活性的一类基因,其功能是抑制细胞周期,阻止细胞数目增多以及促使细胞死亡。p 16基因是新近发现的抑癌基因,它以甲基化、突变或缺失等异常形式广泛存在于各种肿瘤患者中 ...
尹凤媛
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Review of Policy Research, EarlyView.ABSTRACT Public appointments shape the top‐level bureaucracy by serving as a gateway for professionals with different profiles, chosen based on different criteria. In general, the literature has been more interested in analyzing appointments based on merit or sponsorship, based on verification of loyalty to the government or technical competence ...
André Vaz Lopes +1 more
wiley +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2010 【目的】 观察24个常用STR基因座等位基因突变的现象及特点65377; 【方法】 对5 084例肯定亲权关系的案例进行分析,筛选等位基因突变事件,确定突变等位基因的来源,统计各STR基因座的突变率,分析突变的规律及其特点65377; 【结果】 在24个STR基因座中共观察到172个突变事件,STR基因座的突变率介于0 ~ 0.492%65377;每个突变案例的突变基因座数目为1 ~ 3个65377;突变模式符合逐步突变模式,最多突变步数为四步65377;父系突变与母系突变比例为3.55:165377;
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糖尿病、冠心病患者ABCA1基因R219K多态性的频率分布特点
Zhongguo shiyan zhenduanxue, 2011 目的旨在探讨我国北方地区汉族人ABCA1基因R219K多态性的频率分布特点,对血脂水平的影响,及其与冠心病、糖尿病和糖尿病合并冠心病的关系。方法采用改良碘化钠法提取基因组DNA,聚合酶链反应限制性片段长度多态性（PCR-RFLP）法分析ABCA1基因R219K多态性。结果正常对照组ABCA1基因R219K多态性RR、RK、KK基因型频率、R等位基因频率、K等位基因频率分别为28.5%、48.6%、22.9%、52.8%、47.2%;糖尿病组分别为29.6%、63.9%、6.5%、61.5%、38.5 ...
许慧, 彭浩, 蒋莹
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Veterinary Dermatology, EarlyView.ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon +5 more
wiley +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2001 【目的】探讨中国人肝豆状核变性(WD)的分子发病机制和基因诊断的方法。【方法】应用基因工程技术对WD 进行了10 年的分子生物学研究。【结果】①WD 的基因定位研究:通过RFLP 及微卫星多态性分析, 应用两位点及多位点连 锁软件, 建立了中国人WD 基因在D13q14 .2 -3区域的精细遗传连锁图谱, 从而首次对中国人WD 基因进行了精确定位;②WD 基因突变研究:应用PCR-SSCP 及DNA 测序技术, 对39 个家系45 名WD 患者进行该致病基因的21 个外显子突变筛选, 发现 WD
徐评议 +4 more
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