Results 81 to 90 of about 68,002 (248)

转化生长因子β1基因多态性与食管癌的关系

open access: yesZhongguo shiyan zhenduanxue, 2010
目的研究转化生长因子β1(TGF-β1)基因启动子区-800G/A和第1外显子+915G/C基因多态性各等位基因及基因型在食管癌患者中的分布频率,初步分析其基因型及血清水平与食管癌的相关性。方法采用序列特异性引物聚合酶链反应(PCR-SSP)和聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,检测118例食管癌患者和130例正常对照组TGF-β1的基因多态性,包括TGF-β1基因启动子-800G/A、第1外显子+915G/C位点,同时采用酶联免疫吸附试验(ELISA)检测血清TGF-β1水平 ...
唐任光   +5 more
doaj  

Systematic Analysis of ApiAP2 Transcription Factor Gene Family in the Rodent Malaria Parasite Plasmodium yoelii [PDF]

open access: yes, 2016
疟疾是疟原虫(Plasmodiumspp.)感染导致的蚊媒传染性疾病,疟原虫生活周期复杂,经历了多宿主和多细胞形态的转化,每一步都需要精确地基因时空表达调控,转录因子介导的DNA转录水平的调控起到重要作用。 ApiAP2基因家族是疟原虫基因组中预测的为数极少的转录因子基因家族,在人疟原虫和啮齿类动物疟原虫中高度保守。在顶复体亚门生物(包括疟原虫)和植物中,ApiAP2基因编码蛋白均含有一个或者多个60个氨基酸大小的AP2DNA结合结构域,起到激活或抑制转录的作用。 之前的转录谱和蛋白质组学分析发现 ...
赵伊华
core  

Configuration Optimization Design of Magnetic Circuit for Large Magnetostrictive Devices Based on TbDyFe Alloy

open access: yesRare Metals, EarlyView.
ABSTRACT Reliable operation of high‐performance magnetostrictive devices, composed of the giant magnetostrictive material (GMM), that is, the TbDyFe alloy, critically depends on an optimally tailored bias magnetic field. Sufficient intensity and uniformity are essential to induce the ideal initial strain in the GMM, enabling peak reciprocating output ...
Jinan Yu   +12 more
wiley   +1 more source

Genetic diversity of Noctiluca scintillans [PDF]

open access: yes, 2016
夜光藻是一种常见的赤潮藻,在世界大部分近海海域均有分布。目前普遍认为夜光藻只有一个种,但还没有研究探索不同地理种群的夜光藻是否产生了种内变异。本研究通过单细胞PCR以及单细胞克隆文库的方法,比较了中国黄海、东海、南海,墨西哥湾以及阿拉伯海5个海域夜光藻核糖体基因的遗传多样性。主要研究结果如下: 1、发现22种ITS单倍型(n=103),12种28S单倍型(n=25),6种18S单倍型(n=31);这3个基因的单倍型多样度(Hd)分别为0.824、0.670、0.557,核苷酸多样度(π)分别为0 ...
潘永柏
core  

Progress in Surface‐Enhanced Raman Scattering‐Based Volatile Organic Compounds Detection: Materials, Application, and Prospects

open access: yesRare Metals, EarlyView.
ABSTRACT The detection of volatile organic compounds (VOCs) holds significant implications in environmental monitoring and disease diagnosis. Traditional gas detection technologies are constrained by complex operation and high cost, thereby failing to satisfy real‐time detection demands.
Yuening Wang   +11 more
wiley   +1 more source

Cloning and characterization of emp53 from Echinococcus multilocularis [PDF]

open access: yes, 2015
泡状棘球蚴病(Alveolarechinococcosis,AE)是由棘球绦虫属的多房棘球绦虫(Echinococcusmulticularia,Em)幼虫寄生所致的人畜共患寄生虫病,该病被认为是最致命的蠕虫感染病。泡状棘球蚴在宿主体内生长就必须存在一套防御系统来抵御氧化损伤、维持基因组稳定以及细胞凋亡,肿瘤抑制基因p53被誉为“基因组的卫士”,在应对一系列的刺激和损伤时起了非常重要的作用。 尽管p53在细胞的增殖、分化或凋亡中具有重要的作用,但是到目前为止在寄生蠕虫领域还没有p53相关蛋白的研究报道 ...
朱山
core  

Multifunctionality of Magnetic La(Fe, Si/Al)13‐Based Materials: Negative Thermal Expansion and Magnetocaloric Effect

open access: yesRare Metals, EarlyView.
ABSTRACT In recent years, the field of magnetic materials has witnessed a paradigm shift from single‐function applications to multifunctional integration, driven by the growing demand for smart materials in advanced technologies. Among various magnetic systems, La(Fe, Si/Al)13‐series materials have emerged as particularly promising candidates due to ...
Irfan Liaquat   +2 more
wiley   +1 more source

广东菲牛蛭水蛭素基因的克隆和序列测定

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2002
【目的】研究地理因素对水蛭素基因结构变异的影响。【方法】抽提广东菲牛蛭基因组DNA , 根据已发表的水蛭 素基因设计一对引物, 从基因组DNA 扩增出一特异性的大约700 bp 片段, 再回收、克隆和测序。【结果】广东菲牛蛭水蛭素 基因全长为642 bp, 基因有4 个外显子, 被三个内含子隔开。与马尼拉菲牛蛭水蛭素基因Hm1 、Hm2 的同源性分别为90 %与 和88.6 %。【结论】地理因素会影响菲牛蛭水蛭素基因结构的变异。
谭恩光, 刘秀平
doaj  

Brd4 and SEC co-regulate the release of promoter-proximal pausing Pol II [PDF]

open access: yes, 2016
转录的调控过程影响着细胞的分化、基因表达等重要生命过程。近年来伴随着高通量等基因组学技术的发展,研究人员可以在全基因水平上研究基因转录的调控。真核基因的转录过程至少可以分为四个阶段:转录前起始复合物的组装、转录起始、转录延伸以及转录终止。随着高通量测序等技术的发展,生物学家对于转录调控的理解也发生了巨大变化。一直以来研究人员把研究转录调控的重点放在转录的起始,认为转录的起始过程才是转录的唯一限速步骤,然而越来越多的试验证据表明转录的延伸过程也是转录重要的调控限速步骤。在许多基因转录延伸过程中 ...
杨海洋
core  

Electronic Modulation of Cu Sites via Iron Incorporation in Cu5FeS4 Bimetallic Sulfide for High‐Efficiency Oxygen Reduction Reaction

open access: yesRare Metals, EarlyView.
ABSTRACT The sluggish kinetics of the oxygen reduction reaction (ORR) necessitate developing oxygen electrodes with enhanced electrocatalytic activity for practical zinc–air battery applications. In this study, an iron‐doped copper sulfide electrocatalyst (CuFeNS‐PNC) anchored on metal–organic framework‐derived carbon substrates was designed, featuring
Taichong Chitboonyakasem   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy