Results 51 to 60 of about 8,352 (164)
Zhongguo shiyan zhenduanxue, 2019 外泌体最早由Johnstone等在研究网织红细胞成熟过程中囊泡的形成时发现,是一种由各种活细胞通过内体途径产生并分泌的直径在40-100nm级的小囊泡,由脂质双分子层包裹[1]。在外泌体被发现的最初十几年中,它的生物学作用一直没有引起人们足够的重视,直到1996年,有科学家发现B淋巴细胞能够分泌具有抗原提呈作用的外泌体,这种外泌体携带有MHC-II类分子、共刺激分子和黏附分子,能够直接刺激效应CD4+T细胞进而产生抗肿瘤效应[2]。随后 ...
张传霞, 崔雅楠, 金浩范
doaj
Zhongshan Daxue xuebao. Yixue kexue ban, 2022 目的探究环状RNA hsa_circ_0002316（circOMA1）是否参与泌乳素瘤耐药调控及其作用机制是什么。方法通过RT-qPCR检测临床泌乳素瘤标本中circOMA1表达情况（5例敏感泌乳素瘤标本和12例耐药泌乳素瘤标本）。通过慢病毒载体构建稳定表达外源性circOMA1 MMQ细胞系模型进行体外实验，分为MMQ NC组及MMQ OMA1组。通过构建裸鼠皮下肿瘤模型进行体内实验，分为MMQ NC+卡麦角林（CAB）组、MMQ NC+溴隐亭（BRC）组、MMQ OMA1+CAB组、MMQ ...
张译尹 +5 more
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Progress in the role of exosomes in sepsis⁃induced cardiomyopathy [PDF]
"Sepsis is a life⁃ threatening organ dysfunction triggered by a dysregulated host response to infection. Sepsis⁃ induced cardiomyopathy（SICM）is an acute cardiac condition caused by sepsis，characterized by high incidence and extremely high mortality ...
ZHENG Ye*，LI Shaoling，HAN Fei
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Applications in Plant Sciences, Volume 12, Issue 3, May-June 2024.Abstract Premise Conservation policies typically focus on biodiversity hotspots. An alternative approach involves analyzing the evolutionary history of lineages in geographic areas along with their threat levels to guide conservation efforts. Mountains exhibit high levels of plant species richness and micro‐endemism, and biogeographic studies commonly ...
Raquel C. Pizzardo +7 more
wiley +1 more source
The value of exosomes suppressor of cytokine signaling 1， speckled protein 140 and calcyclin binding protein expressions in peritoneal dialysis effluent in the diagnosis of peritoneal fibrosis [PDF]
ObjectiveTo investigate the value of suppressor of cytokine signaling 1 （SOCS1）， speckled protein 140 （SP140）， calcyclin binding protein （CacyBP） expressions in peritoneal dialysis effluent in the diagnosis of peritoneal fibrosis （PF）.MethodsA total of ...
Cao Yan-chun +7 more
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Effects of exosomes of paratumoral thymus epithelial cells on Treg cell function in patients with thymoma-associated myasthenia gravis [PDF]
Objective To investigate the effects of exosomes derived from paratumoral thymic epithelial cells on the expression of forkhead box protein P3 (FOXP3) and the secretion of transforming growth factor-beta1 (TGF-β1) and interleukin (IL)-10 by regulatory T ...
BAO Xiaoran +4 more
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Progress in the treatment of sepsis⁃associated acute kidney injury [PDF]
"Sepsis⁃associated acute kidney injury（SA⁃AKI）is a common critical illness in hospitalized patients，characterized by high incidence，high mortality. The pathogenesis of SA ⁃ AKI is complex，with both direct mechanisms related to infection and indirect ...
LIANG Xinyue*，ZHOU Yun
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Zhongguo shiyan zhenduanxue, 2019 外泌体是由脂质双层膜包裹的,含有蛋白质、多肽和核酸的纳米级细胞外囊泡。目前已经从外泌体中鉴定出4563余种蛋白质、194余种脂类、1639余种mRNA、764余种miRNA等非编码RNA (lncRNAs)以及mtDNA、ssDNA和dsDNA等[1,2]。外泌体含有的多种功能性核酸及蛋白质,在细胞物质转运和信息传递过程中发挥重要作用,影响着细胞的生长与分化。近年来研究表明,lncRNA了参与细胞增殖、分化、染色体重塑、表观遗传调控、转录和转录后修饰等多种生物学过程,也引起大家越来越多的关注 ...
薛婷, 姜义, 史莹, 张颖超
doaj
Role of tubular cell-derived exosomes in renal ischemia reperfusion injury [PDF]
Renal ischemia reperfusion injury refers to a pathophysiological phenomenon that aggravates the degree of renal injury due to the restoration of blood supply after transient ischemia of renal tissue.
Ai-sha Zhang +7 more
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Regulation of mesenchymal stem cell-derived exosomes on helper T cells in periodontitis [PDF]
T helper cells (Th cells) play an important role in periodontitis. During the progression of periodontitis, the levels of pro-inflammatory cytokines such as INF-γ and IL-17, which are produced by Th1 and Th17 cells, are elevated, while the levels of anti-
WEN Yuqi, GUO Shujuan, DING Yi
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