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A Preliminary Study on the Effects of Tartary Buckwheat-derived Nanoparticles on the Physiology of C57BL/6 Mice [PDF]
Objective: To investigate the effects of dietary supplementation with tartary buckwheat-derived nanoparticles (TBDNs) on key physiological parameters in mice.
Chaoqin REN +4 more
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Zhongguo shiyan zhenduanxue, 2020 目的探讨胃癌细胞外泌体中miR-223的表达对胃癌细胞的生物学影响。方法提取血清中外泌体;转染胃癌细胞miR-223;ELISA方法进行细胞因子的检测;RT-PCR方法检测胃癌细胞增殖及侵袭相关基因。结果外泌体中miR-223的表达水平明显低于其他两组;IGF-1R的表达水平明显高于其他两组;Ⅲ、Ⅳ期胃癌患者血清中miR-223的表达水平明显低于Ⅰ、Ⅱ期的水平;miR-223细胞组中PTEN、β-catenin、N-cadherin和E-cadherin的表达水平明显高于NC组。结论 miR ...
王宁 +4 more
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间充质干细胞在器官移植中发挥免疫抑制作用及机制探讨的研究进展 [PDF]
, 2019 器官移植是终末期器官衰竭患者最有效的治疗手段。将间充质干细胞(MSC)用于器官移植已成为细胞疗法的重要组成部分。然而,MSC发挥免疫抑制作用的机制还有待进一步地挖掘,且影响MSC发挥免疫抑制作用的因素很多,这些原因导致MSC难以达到预期疗效。在本综述中将通过介绍MSC的免疫抑制作用及机制、影响MSC发挥免疫抑制作用的因素以及MSC的临床应用等方面来阐述MSC在器官移植领域的研究进展。国家重点研发项目(2018YFA0108304)国家自然科学基金(81771721 ...
于胜男 +9 more
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血浆外泌体microRNA-29c在阿尔茨海默病早期诊断价值的初步研究
Zhongguo shiyan zhenduanxue, 2018 目的初步探讨血浆外泌体内microRNA-29c(miR-29c)在阿尔茨海默病(AD)早期诊断种的价值。方法明确血浆外泌体内miR-29c提取和检测过程的稳定性;检测202例轻度认知障碍(MCI)和痴呆期(DAT)AD患者及120例表面健康受试者的血浆外泌体内miR-29c,建立其生物参考区间,确定截断值,比较其诊断效能。结果对照组、帕金森患者、血管性痴呆患者、MCI和DAT患者miR-29c的回收率均在95%-105%之间,且各组受试者间的回收率无统计学差异(P>0.05 ...
刘辰庚 +4 more
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Function of non-coding RNA in radioresistance in non-small cell lung cancer [PDF]
Lung cancer is not only one of the most common malignancies，but also has the highest mortality rate worldwide，among which non-small cell lung cancer（NSCLC）is the most common subtype.
CHEN Mengdan, WANG Huaying, YU Wanjun
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Research progress in the role of M1/M2 polarization of macrophages in different liver diseases [PDF]
Macrophages have strong plasticity and heterogeneity, and can undergo functional transformation in response to different signal stimuli, such as classical activation of M1 type (M1 type polarization) and selective activation of M2 type (M2 type ...
LI Zhengju +5 more
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Research progress of plant exosome-like nanoparticles on characteristics, components and functions [PDF]
Exosome-like nanoparticles （ELNs） are nano-sized extracellular vesicles enclosed by lipid bilayer membrane and secreted by cells; And carrying a variety of cargo, including lipids, proteins, miRNAs and secondary metabolites.
CHEN Chunping +4 more
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Research advances in functions of Hippo signaling in the immune system [PDF]
, 2017 Hippo信号通路是最早在果蝇(Drosophila)中发现的,在进化上高度保守,具有调控细胞增殖与凋亡作用的一条关键信号转导通路。在哺乳动物中; ,Hippo信号通路在调控细胞增殖、细胞死亡、细胞分化和肿瘤生成等生物学过程中有着十分重要的作用。近年来,Hippo信号通路在免疫系统以及多种功; 能性免疫细胞中发挥的重要作用逐渐成为该领域的研究热点,特别是Hippo信号通路各成员在免疫细胞应对病毒、细菌入侵或肿瘤发生以及维持自身稳态过程中; 发挥着重要的作用。因此 ...
洪丽欣, 耿晶, 陈兰芬
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Zhongshan Daxue xuebao. Yixue kexue ban外泌体是具有脂质双层膜结构的小囊泡，因其非侵入性、高可及性和稳定性应用于精准医学中，在肿瘤的转移、侵袭和血管生成等过程中发挥重要作用。妇科恶性肿瘤主要包括宫颈癌、卵巢癌和子宫内膜癌，其早期诊断和治疗一直是研究的热点和难点。外泌体作为新型的生物学标志物，具有高度特异性，能够有效阻断妇科恶性肿瘤的发生和发展。本文详细探讨了外泌体在宫颈癌、卵巢癌和子宫内膜癌中的诊断和治疗应用。在宫颈癌中，外泌体参与HPV感染、血管生成和免疫逃逸等过程，其携带的特定miRNA（如miR-30d-5p、let-7d-3p ...
张凤梅, 李红芳
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Preliminary study on pigment epithelium-derived factor in serum exosomes as an early neurotoxicity biomarker induced by n-hexane [PDF]
, 2023 FENG Wenting
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