Zhongshan Daxue xuebao. Yixue kexue ban, 2009 【目的】 研究姜黄素对人宫颈癌细胞Caski侵袭转移的影响并探讨其可能的机制。【方法】 以10, 25, 50 μmol/L姜黄素处理Caski细胞24,48,72 h后,MTT法检测其对Caski细胞的生长抑制作用。应用Transwell小室进行人工重组基底膜(Matrigel)侵袭和运动实验,观察姜黄素对Caski细胞侵袭和转移的影响。Western blot检测细胞中MMP-2。MT1-MMP和NF-κB蛋白水平变化。 【结果】应用姜黄素处理后人宫颈癌细胞生长受到抑制且作用呈时效-量效依赖关系 ...
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Zhongshan Daxue xuebao. Yixue kexue ban, 2013 【目的】 探讨姜黄素预先给药对兔单肺通气导致的肺炎性损伤的影响及可能机制。【方法】 将12只健康新西兰白兔随机分为2组,每组6只:开胸单肺通气+对照剂组(组1)和开胸单肺通气+姜黄素组(组2)。两组兔经腹腔注射分别预先给予对照剂和姜黄素,每天早晚各1次。连续给药7 d后,两组兔均经口插入单腔气管导管行右侧单肺通气,并左胸开一小口模拟手术操作。分别于机械通气前(T0)及实验结束前(T4)采集动脉血行血气分析,计算氧合指数。处死动物后,行右侧支气管肺泡灌洗测定髓过氧化物酶 (MPO)含量及中性粒细胞数量 ...
李慧婷
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Zhongshan Daxue xuebao. Yixue kexue ban, 2011 【目的】观察姜黄素对兔单肺通气导致的肺损伤的影响。【方法】12只新西兰白兔随机分为单肺通气组(组Ⅰ)和单肺通气+姜黄素组（组Ⅱ），每组6只。于实验前七天开始灌胃给药，组Ⅰ给予对照剂，组Ⅱ给予姜黄素40mg/kg，每天早晚各一次。两组动物均气管切开插入单腔气管导管（ID:3.5mm）建立右侧单肺通气模型，采用容量通气模式（潮气量 12 mL/kg，呼吸频率40 min-1，I:E=1：2）并模拟左侧开胸手术。先双肺通气30min，再单肺通气3h，恢复双肺通气30min。监测两组兔血气及气道峰压 ...
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姜黄素通过抑制p38 MAPK和AKT活化改善幼鼠过敏性气道炎症 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2017 【目的】选择幼龄小鼠模拟3~12岁儿童的过敏性气道炎症，探索膳食补充姜黄素对幼龄小鼠过敏性气道炎症 的防治作用。【方法】4周幼龄雌性BALB/c小鼠随机分为3组（每组n=8），分别是空白对照组，过敏性气道炎症模型组，姜 黄素干预组。在末次卵清白蛋白激发24 h后，观察各组小鼠的症状，测定肺泡灌洗液（BALF）中的炎症细胞数，全血细胞分 析白细胞亚型的数量，用HE染色观察肺部支气管周围炎症细胞浸润情况，用过碘酸-雪夫染色观察杯状细胞增生情况，酶 联免疫吸附法测定BALF中的细胞因子IL-4、IL ...
陈彦球 +5 more
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Study on MOF-5 Adsorption Curcumin and Digestion in Gastrointestinal Tract(MOF-5吸附姜黄素及在胃肠中的消化研究) [PDF]
Shipin kexue jishu xuebao, 2017 MOF-5 was prepared by a direct synthesis method. Effects of MOF-5 mass, curcumin concentration, adsorption temperature and and adsorption time were investigated by the single-factor experiment. Based on the results, the orthogonal test method was used to
LIU Ya(刘亚) +4 more
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Study on Properties of High Concentration Emulsion Loaded Curcumin and Its Influence on Quality of Emulsified Sausages(负载姜黄素的高浓度乳化物对乳化肠品质的影响) [PDF]
Shipin kexue jishu xuebao, 2019 Curcumin has strong physiological and pharmacological activities. However, its bioavailability and application in food industry is limited due to the low solubility in water.
FANG Aihu(方艾虎) +4 more
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Construction of Bilayer Emulsion Based on Layer-by-Layer Electrostatic Deposition Technology and Its Effects on Stability and Bioaccessibility of Curcumin(基于逐层静电沉积技术的双层乳液构建及其对姜黄素稳定性与生物可及性的影响) [PDF]
Shipin kexue jishu xuebaoTo address the problem of low bioavailability of curcumin due to poor water solubility and environmental sensitivity, an oil-in-water bilayer emulsion delivery system was constructed to improve the stability and bioaccessibility of curcumin.
ZHANG Sairui(张赛睿) +4 more
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Antibacterial Effect and Mechanism of Curcumin Mediated Photodynamic Inactivation Combined with Phage on Foodborne Pathogens(噬菌体协同姜黄素介导的光动力灭活对食源性致病菌的杀菌效果及机理) [PDF]
Shipin kexue jishu xuebaoPhotodynamic inactivation (PDI) is a new environmentally friendly non-thermal sterilization technology that can effectively inactivate foodborne pathogens.
YANG Yuanping(杨园平) +1 more
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Construction of Co-Delivered Curcumin and EGCG Liposomes and Their Effects on Neuroinflammation(共递送姜黄素和EGCG脂质体的构建及其对神经炎症的作用) [PDF]
Shipin kexue jishu xuebaoTo overcome the limitations of two bioactive components, curcumin and epigallocatechin gallate (EGCG), in terms of stability and metabolic kinetics, and to further exploit their synergistic antioxidant and anti-inflammatory effects, liposomes co ...
MA Dexue(马德雪) +3 more
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, 2018 以最简单的真核生物——酿酒酵母为材料,利用姜黄素的荧光性质,借助荧光光谱法和荧光显微镜研究了姜黄素在酵母细胞中的定位及其对酵母生长的影响.结果表明,姜黄素可以进入酵母细胞中并抑制酵母生长,初步得到了姜黄素对酵母作用的量效关系和时间效应结果,证明了姜黄素可以与酵母细胞线粒体结合.本文结果为以酵母为模型研究姜黄素通过线粒体影响细胞代谢及其与细胞凋亡的关系奠定了基础.国家自然科学基金(批准号:81373296);;厦门大学细胞应激生物学国家重点实验室开放课题(批准号:SKLCSB2017KF003)资助~
程元初 +4 more
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