Results 1 to 10 of about 1,200 (146)
PT109改善链脲佐菌素诱导的散发性阿尔茨海默病小鼠认知功能障碍的作用及机制 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的观察PT109能否改善侧脑室注射链脲佐菌素（icv-STZ）诱导的散发性AD小鼠模型的认知功能障碍并对其机制进行初步探讨。方法32只7周龄雄性C57BL/6小鼠分为正常组（7只）、模型组（7只）、PT109低剂量组（9只）、PT109高剂量组（9只）。将STZ于第1和3天注射入小鼠侧脑室建立散发性阿尔茨海默病小鼠模型；（3mg/kg，每个注射位点5μL）造模后，分别腹腔注射PT109（30、100 mg·kg-1·d-1），2周后通过Morris水迷宫和避暗实验评价小鼠学习记忆能力；随后通过免疫荧光、
陈秋荷 +5 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2005 【目的】探讨早期和延迟高压氧(HBO)治疗对缺氧缺血性脑损伤(HIBD)新生大鼠的远期影响。【方法】7日龄大鼠37只随机分为对照组(n=10，假手术处理)、HIBD组(n=9)、EHBO组(n=9，HIBD模型后0.5～1h开始2个绝对大气压HBO治疗，稳压30min／次，间隔24h，连续2次)和LHBO组(n=9，HIBD模型后48～72h开始2个绝对大气压HBO治疗，稳压30min／次，间隔24h，连续5次)，以大鼠远期的学习记忆功能(Morris水迷宫实验)和海马形态组织学 ...
刘美娜
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Research Progress on the Effect of Synthetic Cathinones on Animal Behavior [PDF]
, 2021 Synthetic cathinones are a class of new psychoactive substances with a structure similar to amphetamine drugs, which can produce excitatory effects similar to drugs such as amphetamine and cocaine after being taken.
HUANG Zhi-bin, CAI Juan, LIN Ze-bin, et al.
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Research and development progress of Semen ziziphi spinosae oil [PDF]
, 2020 Semen ziziphi spinosae oil is a kind of safe edible oil for health care comes from Suanzaoren which have the functions of both medicine and food.This article reviews the extraction technology，composition analysis and biological activity of Semen ziziphi ...
LI Xiao-yan +4 more
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Effects of Different Concentrations of Alcohol On Spatial Learning and Memory Ability and Hippocampal GFAP/NEUN in Mice [PDF]
, 2017 目的 探究长期饮酒对小鼠行为学能力以及空间学习记忆能力的影响。方法 雄性KM小鼠45只,随机分成对照组（Con）,低剂量组（Low）和高剂量组（High）。分别每天对照组0.10 ml/10 g自来水,低剂量组0.05 ml/10 g的56度红星二锅头,高剂量组0.10 ml/10 g的56度红星二锅头进行灌胃。连续灌胃13 d后进行衣架实验测行为学能力,最后取海马做免疫荧光染色观察海马神经元和星形胶质细胞。结果衣架实验得分,自主活动数值总体显示Low组高于其他两组,而且与Con组差异显著 ...
夏天 +7 more
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Change of transcription factor EB activity and autophagy in hippocampus of type 2 diabetic encephalopathy mice [PDF]
, 2023 Objective·To investigate the changes of transcription factor EB (TFEB), the activity of the upstream proteins and autophagy in the hippocampus of mice with type 2 diabetic encephalopathy.Methods·Twenty healthy 8-week-old male C57BL/6J mice were randomly ...
CHEN Yixin +3 more
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Developmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019 目的 本国际临床指南由欧洲残疾儿童学会（the European Academy of Childhood Disability，EACD）牵头制定，旨在解决发育性协调障碍（developmental coordination disorder，DCD）的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题，通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础，以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类，最终转化为指南建议。并由国际 ...
Jing Hua +6 more
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Non-targeted Metabolomic Study on Anti-aging Effect of Ripe Pu-erh Tea on D-Galactose-Induced Aging Mice [PDF]
, 2023 Delaying aging has become a hot spot of social concern and research. Our previous studies have shown that ripe Pu-erh tea can delay aging in mice by regulating the intestinal flora, but the metabolites in response to endogenous substances in mice are not
LEI Shuwen, ZHANG Zhifang, XIE Guihua, SHAN Bo, MIAO Yue, ZHAO Chunyan, CHEN Dehong, HOU Yan, GONG Jiashun,
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野生动物学报, 2022 综述光照对哺乳动物学习和记忆的影响及其基础机制的结果表明,强光照刺激可以引起哺乳动物昼夜节律紊乱、生理性节律紊乱、睡眠节律紊乱、视网膜损伤和激素分泌紊乱等,并导致空间学习记忆障碍。其中昼夜节律紊乱、视网膜损伤、激素分泌紊乱、突触可塑性过低和内在光敏感视网膜神经节细胞介导可能是强光照刺激引起哺乳动物机体认知障碍的主要机制。研究结果可为进一步研究强光照对哺乳动物学习和记忆的影响提供理论依据。
彭鸿碧 1 贾 婷 2 王政昆 1 朱万龙 1
doaj
Z-十八碳-9-烯-丙磺酰胺对糖尿病认知功能障碍小鼠学习记忆功能的影响 [PDF]
, 2018 探索新化合物Z-十八碳-9-烯-丙磺酰胺（N15）对糖尿病认知功能障碍（DACD）小鼠学习记忆功能的作用及机制。采用链脲佐菌素（STZ）连续小剂量腹腔注射以及高脂高糖加STZ诱导2型糖尿病小鼠模型,N15(50和100mg·kg-1·d-1)连续灌胃给药6周,于给药末期进行跳台、避暗以及Morris水迷宫测试以评价小鼠学习记忆功能;对海马内葡萄糖和乳酸水平进行测定;通过realtimePCR测定海马内突触成长相关蛋白-43（GAP-43）、突触素（SYN）、脑源性生长因子（BDNF）和神经营养因子-3 ...
任桐 +8 more
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