Comparative transcriptomics analysis between the fifth larvae and females of Angiostrongylus cantonensis and the expression pattern analysis of AC-14-3-3 [PDF]
, 2016 广州管圆线虫（Angiostrongyluscantonensis）是一种非常重要的人畜共患病病原寄生虫，近年来已在更广的宿主和地理分布范围内发现了该寄生虫感染的存在。然而，在公共数据库中可获得的相关资源信息非常有限，这极大地限制了人们对该寄生虫在入侵宿主、寄生生活和免疫逃避等方面机制的深入研究，也严重影响了在该病诊断、治疗和抗虫疫苗研制等领域的发展。 广州管圆线虫第五期幼虫（L5）既是可以在人和小鼠等偶然宿主脑内长期存活并引起嗜酸性脑膜脑炎的时期，又是在天然宿主体内可以突破血脑屏障进入肺动脉的时期 ...
余良
core
Integrative Conservation, Volume 3, Issue 4, Page 353-367, December 2024.The One Plan Approach to Conservation of the International Union for Conservation of Nature highlights the importance of combining on‐site conservation actions with captive breeding efforts. Among vertebrates, amphibians are one of the groups with the highest proportion of species threatened with extinction.
Marie Borgwerth +6 more
wiley +1 more source
Proteomic Response of Alexandrium catenella to Ambient Phosphorus Depletion and Resupplement [PDF]
, 2017 链状亚历山大藻（Alexandriumcatenella）是一种全球分布的有毒甲藻。研究表明，磷（Phosphorus，P）是链状亚历山大藻细胞生长和藻华形成的限制性因子。目前有关链状亚历山大藻对磷缺乏的生理生态响应已有一些研究，但对于其分子机制尤其是蛋白质层面上的研究仍较少。 本论文以链状亚历山大藻（A.catenella）为研究对象，运用iTRAQ（Isobarictagsforrelativeandabsolutequantitation）定量蛋白质组学技术，比较研究了A ...
陈颖
core
Constructing adverse outcome pathway for per- and polyfluoroalkyl substances and retinoblastoma based on PI3K-AKT/MAPK signaling pathway [PDF]
BackgroundExposure to per- and polyfluoroalkyl substances (PFAS) is associated with various cancers, and recent studies suggest it may also increase the risk of retinoblastoma (RB) in newborns.
Minghao WANG +4 more
core +1 more source
Using positionality and reflexivity to support equity in partnership‐driven research
Conservation Biology, Volume 38, Issue 6, December 2024.Abstract Social and economic position and power shape everyone, including scientists and researchers. The way researchers do conservation science and the voices centered in the process are a result of researcher upbringing, experiences, access to resources, and values and are a manifestation of positionality.
Rachael Cadman +8 more
wiley +1 more source
霍乱弧菌新发菌株中
Zhongshan Daxue xuebao. Yixue kexue ban, 2022 目的探索霍乱弧菌新发菌株H1的六型分泌系统（T6SS）存在的转录调控机制。方法本研究以转录组测序为基础，分析H1株分别由于vipA敲除（H1ΔvipA），vipB敲除（H1ΔvipB）和clpV敲除（H1ΔclpV）时T6SS基因簇的转录水平，并对其差异基因进行了基因本体论（GO）富集和京都基因与基因组百科全书（KEGG）富集。结果发现H1ΔvipA有22个差异基因（FDR<0.01，|log2FC|≥1），其中有18个属于T6SS基因簇；并且除vipA外，其转录水平均呈上升趋势 ...
吴文轩, 郭扬, 张幸鼎, 赵文婧
doaj
Exploring the role of methylation-driven gene IFFO1 in pancreatic adenocarcinoma diagnosis, prognosis and cellular functions [PDF]
Background and purpose: Abnormal DNA methylation is closely associated with the onset and progression of tumors. This study aimed to investigate the expression of intermediate filament family orphan 1 (IFFO1), a methylation-driven gene (MDG) in ...
XU Ziqi, HU Ruizhi, LI Junjian, WANG Hongxia, SANG Youzhou
core +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2017 【目的】通过生物信息学的方法发现特发性肺纤维化（IPF）的致病基因并为进一步研究提供靶点。【方法】从 GEO数据库中下载基因芯片数据集GSE53845、GSE24206、GSE10667，并使用GEO2R分析工具筛选出正常组织与IPF的差异 表达基因。在DAVID数据库中对差异表达基因进行GO分析和KEGG通路富集分析，以便找到IPF发病过程中差异表达基 因主要参与的生物功能及其集中的信号通路。为了研究差异表达基因与蛋白之间的作用关系，使用 STRING 和 CYTO ...
黄鑫炎, 郭禹标
doaj
利用Illumina MiSeq测序平台分析健康与腹泻食蟹猴粪样菌群
野生动物学报, 2019 本试验通过对比健康与腹泻食蟹猴粪便菌群的差异，初步探讨腹泻对食蟹猴粪便菌群的影响。采集成年腹泻与健康食蟹猴粪样各6份，用细菌16Sr DNA通用引物扩增V3—V4 区，采用Illumina MiSeq测序平台对食蟹猴粪便微生物进行研究。结果表明，Alpha多样性指数分析，健康组与腹泻组的微生物多样性指数（Shannon、Simpson）差异不显著，群落丰富度指数（Chao、Ace）差异显著。PCA主成分分析，健康组与腹泻组粪便菌群具有明显的差异。通过对健康组与腹泻组物种菌群组成分析 ...
张飞燕 1 金洁 1 刘超 1 胡正飞 1 张玉林 1 谢丽分 1 邬继文 1 吕龙宝 1
doaj
Comparison of human-induced pluripotent stem cell-derived macrophages with peripheral blood-derived macrophages using single-cell genomics [PDF]
Objective·To explore the heterogeneity in single-cell genomics between human-induced pluripotent stem cell (iPSC)-derived macrophages (IPSDM) and human peripheral blood-derived macrophages (PBDM).Methods·iPSCs were differentiated into IPSDMs in vitro ...
HOU Guojun, SHEN Nan, ZHANG Yutong
core +1 more source