Results 31 to 40 of about 2,294 (165)
The phosphorylation of BAG3 by CDK5 and its roles in astrocytes [PDF]
, 2016 细胞周期素依赖性蛋白激酶5（Cyclin-DependentKinase5，CDK5)是细胞周期蛋白依赖性丝氨酸/苏氨酸蛋白激酶家族中的一个成员，在神经系统的发育中发挥了至关重要的作用。CDK5的调节亚基P35、P39是神经系统特异性表达的蛋白，因此赋予了CDK5在神经系统中特异的激酶活性，使CDK5在调控神经递质传递，神经元凋亡等方面发挥了重要作用。对于CDK5的研究一直集中在对其新底物的发现和鉴定上，至今为止有40余个CDK5的底物被鉴定出来。作为脯氨酸依赖性蛋白激酶，CDK5可以特异磷酸化包含有 ...
张冠云
core
US Foreign Policy and the Gulf States: Changing Dynamics in a Multipolar World
World Affairs, Volume 188, Issue 4, Winter 2025.ABSTRACT This article focuses on US foreign policy toward the Gulf from Obama's Pivot to Asia to the initial period of the second Trump administration. It situates the role of the US within the broader context of the global energy transition and the Gulf states as geopolitical actors in a multipolar world order.
Steven Wright
wiley +1 more source
Vulnerability of tropical fish communities across depth in the central Indian Ocean
Conservation Biology, Volume 39, Issue 6, December 2025.Abstract Coral reefs and their fish communities below scuba diving depth (>30 m), in mesophotic coral ecosystems (MCEs) (∼30–150 m), in rariphotic (150–300 m), and in upper bathyal waters (300–500 m) are often underexplored, especially in the Indian Ocean.
Paris V. Stefanoudis +12 more
wiley +1 more source
oleoylethanolamide improves spatial cognitive deficits through enhancing hippocampal neurogenesis after cerebral ischemia [PDF]
, 2015 我们先前的研究表明油酰乙醇胺（OEA）对急性脑缺血损伤具有神经保护作用。本研究的目的是探讨OEA对脑缺血引起的空间认知障碍，海马长时程增强作用（LTP）的抑制作用和海马神经发生的影响。结果表明：OEA30mg/kg显著改善大鼠脑缺血后空间认知功能障碍，促进海马长时程增强。另外，我们证实OEA通过促进海马神经发生改善脑缺血后的认知障碍。进一步的研究表明，OEA明显增加海马组织脑源性神经营养因子（BDNF）和过氧化物酶体增殖活化受体（PPARα）的表达 ...
杨立朝
core
Recent advance in autophagy-related pathways and key biomarkers in major depressive disorder [PDF]
, 2023 Major depressive disorder (MDD) is a very common and severe mental disorder. Persistent emotional distress is one of its main clinical symptoms. The etiology of MDD is complex and highly heterogeneous, and has not yet been clarified.
HE Shen, LI Huafang, LI Siyuan
core +1 more source
Using online reports of seahorse seizures to track their illegal trade
Conservation Biology, Volume 39, Issue 5, October 2025.Abstract Illegal wildlife trade (IWT) is a persistent and extensive threat to global biodiversity. Hundreds of marine fish species are subject to regulation under the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES), but it is unclear how much protection species gain from CITES because information on marine fish ...
Sarah J. Foster +3 more
wiley +1 more source
The role of LRP1 in microglia and neuroinflammation [PDF]
, 2016 神经炎症以中枢神经系统中小胶质细胞的激活、炎症因子以及趋化因子的大量表达为特征。小胶质细胞作为脑内最主要的免疫和吞噬细胞，在神经损伤以及包括阿尔兹海默症（Alzheimer’sdisease，AD）在内的神经退行性疾病中过度激活，同时起到神经保护或者毒性损伤功能。作为载脂蛋白E（apolipoproteinE，apoE）和β淀粉样蛋白（amyloid-β，Aβ）最主要的受体，低密度脂蛋白受体相关蛋白1（low-densitylipoproteinreceptor-relatedprotein1，LRP1）
杨龙雨
core
Improvements for better scaling of locally managed marine areas
Conservation Biology, Volume 39, Issue 5, October 2025.Abstract To protect and restore ecosystems at the speed and scale required to meet current environmental challenges, a greater understanding of how conservation initiatives spread from existing to new adopters is required. According to the diffusion of innovation theory, positive adopter‐to‐peer communication is a powerful driver of innovation spread ...
Emily Lewis‐Brown +6 more
wiley +1 more source
Integrative Conservation, Volume 4, Issue 3, Page 430-441, September 2025.Our study identifies southern China, including mountainous regions and islands, as key areas rich in phylogenetic diversity, and phylogenetic endemism of lizards that are currently under‐protected. Current protected areas however do not adequately cover regions that are critical for preserving the evolutionary history of lizards.
Tao Liang (梁涛) +8 more
wiley +1 more source
Integrative Conservation, Volume 4, Issue 3, Page 476-490, September 2025.The leaf functional traits of angiosperms and gymnosperms in mountain ecosystems significantly influence phyllosphere fungal diversity. These traits are critical for understanding fungal stress resistance and elevational adaptation, which aids in predicting plant responses to climate change.
Xiaocheng Yu +7 more
wiley +1 more source