鼠李糖乳杆菌对老年小鼠术后海马区小胶质细胞激活及Tau蛋白磷酸化的影响 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban目的探讨术前益生菌鼠李糖乳杆菌（LGG）灌胃对麻醉手术老年小鼠海马区小胶质细胞及Tau磷酸化的影响。方法18月龄C57BL/6J小鼠30只随机分为3组，10只/组：对照组，麻醉手术组，麻醉手术+鼠李糖乳杆菌组。生理盐水/LGG 109 CFU 150 μL灌胃，每日 1 次，连续20 d后接受异氟醚麻醉+剖腹探查手术，术后12 h免疫荧光染色检测海马区小胶质细胞激活状态，ELISA 检测IL-6的浓度变化，Western blot 检测Tau蛋白磷酸化位点Tau-pS202/pT205和total ...
刘玲, 刘付宁
doaj +6 more sources
PT109改善链脲佐菌素诱导的散发性阿尔茨海默病小鼠认知功能障碍的作用及机制 [PDF]
, 2021 目的观察PT109能否改善侧脑室注射链脲佐菌素（icv-STZ）诱导的散发性AD小鼠模型的认知功能障碍并对其机制进行初步探讨。方法32只7周龄雄性C57BL/6小鼠分为正常组（7只）、模型组（7只）、PT109低剂量组（9只）、PT109高剂量组（9只）。将STZ于第1和3天注射入小鼠侧脑室建立散发性阿尔茨海默病小鼠模型；（3mg/kg，每个注射位点5μL）造模后，分别腹腔注射PT109（30、100 mg·kg-1·d-1），2周后通过Morris水迷宫和避暗实验评价小鼠学习记忆能力；随后通过免疫荧光、
侯加卫 +5 more
core +1 more source
Construction and characterization of mice with conditional knockout of Stat3 gene in microglia [PDF]
, 2023 Objective·To construct mice with conditional knockout of Stat3 gene in microglia based on the Cre-Loxp system and validate their knockout efficiency.Methods·Cx3cr1creERT2 and Stat3fl/fl genotypic mice were bred for conditional knockout mice (CKO) and ...
HE Zhiyan +5 more
core +1 more source
Developments in the Role of Iron Imbalance in the Pathogenesis of Alzheimer's Disease [PDF]
, 2022 Iron load is closely associated with the initiation and progression of Alzheimer's disease (AD) . Although age-dependent deposition of β-amyloid (A β) in senile plaques (SPs) , and neurofibrillary tangles (NFTs) formed by accumulation ...
GUO Shuang, CHEN Fengyan, YIN Xiang, WANG Lu, GUO Xuefeng, YU Qiming, ZOU Zhenyou, SHU Wei
core +1 more source
Epilepsy and Cognitive Disorders [PDF]
, 2017 癫痫是一种慢性疾病,是神经系统较常见的疾病,其发病率与病死率均较高。随着社会医学的不断发展,癫痫引起了越来越多的关注,因影响因素较多,癫痫与认知功能障碍之间的相互关系尚未明确。本文主要从癫痫引起认知功能损害的机制、癫痫患者认知功能的影响因素以及不同癫痫治疗方式对认知功能的影响多角度分析癫痫对认知功能的影响,以期提高人们对癫痫患者认知功能障碍的关注,提高癫痫患者的生活质量,并为临床工作者提供研究方向。Epilepsy is a common chronic neurological disease ...
遆悦, 郑维红
core +1 more source
, 2018 从PM2.5对阿尔茨海默病的标志物、炎症、脑的发育及其他因素造成的影响等方面入手,综合阐述了PM2.5与阿尔茨海默病之间的联系。PM2.5引发阿尔茨海默病的机制尚不明确,我们推测PM2.5导致的阿尔茨海默病的标志物增多、炎症反应及氧化损伤等可能是引发该病的重要原因。中国博士后科学基金面上资助项目 ...
王娜, 钟力, 魏敏
core +1 more source
Advances in the Study of Natural Product Polysaccharides for the Relief of Depression and Their Mechanisms [PDF]
, 2023 Depression, as a common mental disorder, is often alleviated and treated with antipsychotic drugs in clinical practice. However, long-term use of such drugs can lead to serious sequelae such as drowsiness, nausea and memory loss in patients.
Yuhe BAI
core +1 more source
High-performance liquid chromatography-mass spectrometry-based acetylcholinesterase assay for the screening of inhibitors in natural medicinal plants [PDF]
, 2016 酶是治疗多种疾病的重要靶标，乙酰胆碱酯酶（AChE）的抑制剂是现阶段治疗阿尔兹海默症（AD）最有效的一类药物。从天然产物中寻找适宜患者长期服用、毒副作用小、作用面广等优点的乙酰胆碱酯酶抑制剂（AChEIs）受到了科研工作者的广泛关注。本论文以AChE作为药物靶标，构建基于高效液相色谱-质谱联用技术（HPLC-MS）的在线生物活性检测方法，发展集分离纯化、结构确证和活性筛选于一体的活性导向天然产物研究方法，用来寻找和发现天然药用植物中潜在的AChEIs候选化合物 ...
刘静兰
core
Harnessing social media data to track species range shifts
Conservation Biology, EarlyView.Abstract Biodiversity monitoring programs and citizen science data remain heavily biased toward the Global North. Especially in megadiverse countries with limited biodiversity records, incorporating social media data can help address existing data gaps.
Shawan Chowdhury +15 more
wiley +1 more source
The Expression of PolySia/TriSia Associated Proteins and Genes on Developing Brain and the Effect of Dietary Sialic Acid Intervention in Piglets [PDF]
, 2015 摘要 研究背景：唾液酸（Sialicacid,Sia）是一类九碳单糖神经氨酸的总称，在细胞表面发挥其多种生物学功能。在体内，Sia通常以游离唾液酸、聚唾液酸（多聚/寡聚）、唾液酸衍生物（糖蛋白，糖脂）这三种形式存在。多聚唾液酸（polySialicacid,ploySia），一种唾液酸残基通过α2-8键连接而成的线性聚合物，广泛分布于在哺乳动物神经系统中，它的主要蛋白载体是神经细胞粘附因子（Neuralcelladhesionmolecule,NCAM）。PolySia-NCAM在细胞迁移、神经突生长 ...
任贺
core