Results 11 to 20 of about 1,280 (139)
铁死亡相关基因热休克蛋白A5与肝细胞癌因果关系的孟德尔随机化和中介分析 [PDF]
浙江大学学报. 医学版目的探讨铁死亡相关基因热休克蛋白A5（HSPA5）与肝癌发展的因果关系及其作用机制。方法采用两步两样本孟德尔随机化（MR）设计评估HSPA5、调节性T细胞及肝癌之间的因果关系。首先通过公开的全基因组关联研究（GWAS）数据库筛选与HSPA5、调节性T细胞、肝癌相关的单核苷酸多态性作为工具变量，采用MR分析HSPA5对肝癌的直接影响，接着通过两步MR分析调节性T细胞在这一过程中可能的中介作用。同时，以肝癌为暴露因素，HSPA5为结局变量进行了反向MR分析 ...
崔 兵 +5 more
doaj +2 more sources
Research progress in ferroptosis regulation in the treatment of liver diseases [PDF]
, 2023 Ferroptosis is a form of cell death that results from accumulation of lipid reactive oxygen species, marked by iron-dependent oxidative damage of phospholipids. Accumulation of iron and lipid hydroperoxides are hallmarks of ferroptosis.
CHEN Chen +3 more
core +1 more source
Journal of Traumatic Stress, Volume 35, Issue 5, Page 1460-1471, October 2022., 2022 Abstract This study examined posttraumatic stress disorder (PTSD), complex PTSD, depression, and anxiety among U.K. rail workers. A cross‐sectional survey examining exposure to seven psychosocial hazards (bullying/harassment; verbal abuse; physical and sexual assault; and hearing about, seeing the aftermath of, or witnessing a fatality), working ...
Laurence A. Carnall +3 more
wiley +1 more source
Advances in fundamental and translational breast cancer research in 2022 [PDF]
, 2023 According to the data released by the International Cancer Research Institute of the World Health Organization (WHO), breast cancer is the malignant tumor with the highest incidence rate in women, and seriously endangers women's health.Many impressive ...
WANG Ziyu, XIAO Yi, JIANG Yizhou, SHAO Zhimin
core +1 more source
Advances on mechanisms of regulated cell death in neurotoxicity of aluminum [PDF]
, 2023 Aluminum is a light metal which is rich in the earth's crust and widely used. Recently, the adverse health effects of environmental and occupational aluminum exposure on human have attracted more and more attention. Aluminum exposure has toxic effects on
Guangzi QI +6 more
core +1 more source
, 2021 运动训练是脑卒中后康复治疗的主要手段。运动训练可以促进脑卒中后神经功能的恢复，其作用目前普遍认为与神经可塑性有关，但具体机制未明。运动训练的神经可塑性机制是当前脑卒中康复研究领域的热点问题。运动训练可以调节脑卒中后脑内血流动力学变化、血管新生、神经炎症反应、营养因子分泌、神经细胞死亡及新生等。本文基于国内外研究，探讨脑卒中后最适的运动干预方案，并结合我们团队在运动训练促进脑卒中后神经功能恢复方向所做的系列研究工作 ...
胡昔权
core +1 more source
铁死亡与卒中相关性研究进展 Progress of Correlation between Ferroptosis and Stroke
Zhongguo cuzhong zazhi, 2019 铁死亡是近些年新发现的一种程序性细胞死亡方式，参与到多种急性和慢性疾病的病 理过程中，其引发机制主要包括铁依赖性的活性氧自由基蓄积和多元未饱和脂肪酸的消耗。卒中一 直以高死亡率和致残率受到全世界研究者的广泛关注，但关于铁死亡在卒中致病机制中的研究目前 还较少，本文分别从铁死亡与出血性及缺血性卒中两方面对已有的最新研究成果进行回顾总结。 Abstract: Ferroptosis is a newly discovered programmed cell death in recent years,
李俞辰，刘耀，刘斌冰，田杨，史怀璋
doaj +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2022 心肌缺血/再灌注损伤（I/R）是再灌注治疗的重要并发症，也是心血管疾病和急危重症患者死亡的主要原因之一，其发病机制复杂，目前临床上尚缺乏有效的防治措施。铁死亡（ferroptosis）是近年来发现的一种全新的调节性细胞死亡方式，是各类疾病发病机理及治疗靶点的热点研究领域。已有研究指出铁死亡与心肌I/R的病理生理过程密切相关。本文综述了近年来铁死亡在心肌I/R中的相关研究进展，以期为心肌I/R的预防和治疗提供新参考。
刘思齐, 杨正飞
doaj
Air pollutants as drivers of cellular stress in neurons and microglia in the brain [PDF]
Air pollution is a growing global health concern, with increasing evidence linking exposure to particulate matter (PM) to neurodegenerative diseases such as Alzheimer’s disease (AD).
Yan, Hong
core +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的探究丙烯醛是否能够诱发体内外发生铁死亡现象。方法体外：给予小鼠海马神经元细胞系HT22细胞丙烯醛进行造模，采用铁死亡抑制剂铁抑素-1（Fer-1）与去铁胺（DFO）进行保护。MTT法检测细胞存活率；自由基探针二氢乙啶（DHE）与亚铁探针FerroOrange检测细胞内自由基与亚铁离子含量；透射电镜观察正常与模型组的线粒体超微形态与结构；Western blot法检测铁死亡相关蛋白表达的情况。体内：雄性C57BL/6小鼠，7~8周龄每日给予3 mg/kg的丙烯醛分别进行造模1、2、4周 ...
彭伟嘉 +4 more
doaj