Results 41 to 50 of about 1,375 (156)
Zhongguo shiyan zhenduanxue, 2022 目的 在胆管癌（CCA）中用铁死亡相关长链非编码RNA(lncRNA)建立有较好的预测能力的预后模型。方法 从TCGA数据集下载CCA的转录组RNA-seq数据和相应的临床数据。采用Pearson相关法筛选与铁死亡相关的差异表达的lncRNAs。单因素Cox回归分析用来筛选与预后相关的lncRNAs。通过多因素回归分析构建预后模型，采用受试者工作特征曲线（ROC）下面积和Kaplan-Meier曲线对模型进行评价。结果 筛选出3个铁死亡相关的差异表达lncRNAs:LINC01714 ...
张琳, 石张镇, 白元松
doaj
Research Progress on Mechanism of Action of DHODH in Progression of Malignant Tumors [PDF]
Dihydroorotate dehydrogenase (DHODH) is a flavin-dependent metabolic enzyme that oxidizes dihydroorotate acid to orotic acid in the de novo synthesis pathway of pyrimidine metabolism.
CHE Xin +3 more
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Zhongguo shiyan zhenduanxue, 2023 铜(Cu)是人体必须的微量元素,在线粒体呼吸、抗氧化防御和生物复合物合成等多种细胞生命过程中发挥重要辅助功能[1]。然而,生理条件下细胞内Cu浓度较低,Cu浓度小幅度升高可能引起细胞毒性,甚至导致细胞死亡[2]。细胞内铜的摄取、分布和消除等过程受到机体严格调控。基因突变导致Cu过量累积与多种致命性疾病的发生密切相关。因此,充分理解细胞内Cu积累和代谢机制对于疾病的治疗至关重要[3]。铜死亡是一种由Cu2+过度蓄积引发的细胞调控性死亡方式,不同于细胞凋亡、铁死亡和坏死[4]。铜死亡发生的过程如下 ...
单关月 +4 more
doaj
Characterization of hub genes associated with ferroptosis in diabetic nephropathy [PDF]
Objective To identify hub genes associated with ferroptosis in the progression of diabetic nephropathy （DN） through bioinformatics analysis， offering novel insights into DN treatment.
ZHAO Sheng, LI Wenchuan, DONG Lan, LIAN Rong, LI Yuejiao, HE Feng
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Astaxanthin Reduces Retinal Damage in Diabetes Mice by Inhibiting Iron Death through Regulating Nrf2/Gpx4 Signaling Pathway [PDF]
Objective: To investigate the effect and mechanism of astaxanthin on retinal damage in diabetes mice. Methods: The mice were randomly divided into four groups: Normal group, model group, low-dose astaxanthin group and high-dose astaxanthin group. Retinal
Jia LIU +6 more
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Research Progress in Ferroptosis during Postmortem Aging of Muscle and Its Relationship with the Quality of Fresh Meat [PDF]
Water-holding capacity, texture and color are important indicators of fresh meat quality. In China, drip loss and textural deterioration of fresh meat are critical problems in the meat industry, causing greater quality loss than that in developed ...
HAO Danni, TU Xiaohang, GUO Shiyu, ZHU Yongzhi, WANG Daoying, XU Weimin, LI Pengpeng
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Inhibitory Effect and Mechanism of Procyanidin B2 on High Glucose-Induced Ferroptosis in SH-SY5Y Cells [PDF]
Objective: To investigate the neuroprotective effect and mechanism of procyanidin B2 on high glucose-induced ferroptosis in differentiated SH-SY5Y cells.
WANG Jiaqi, CHEN Xiuting, XIA Xing, ZHOU Jinling
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Research progress of ferroptosis in the occurrence and development of periodontitis [PDF]
Periodontal disease is a chronic infectious disease characterized by chronic inflammation and progressive destruction of the periodontal tissue. Ferroptosis, an iron-dependent form of programmed cell death, is primarily characterized by altered iron ...
SUN Ruiman, QIN Xu, ZHU Guangxun
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Advances in fatty acid metabolism reprogramming of lung cancer [PDF]
, 2023 Lung cancer is the most common malignant tumor and the leading cause of cancer-related mortality. Although the development of targeted therapy and immunotherapy has significantly improved the efficacy and prognosis of lung cancer patients, the overall 5 ...
WU Jing, ZHOU Juan, SU Chunxia
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实用医学研究, 2020 缺血性脑卒中是脑卒中的主要类型,其发生后 神 经 元 死 亡 是 造 成 神 经 功 能 损 伤 的 最 主 要 原 因。除 凋 亡、坏 死 外,近年来许多新的细胞死亡方式被发现,包括焦亡、PARP-1依赖性细胞死亡、铁死亡、胀亡等。本文旨在对缺血后脑中神经 元 的死亡方式及其研究进展予以综述。
琳函 张, 卫艳 尤
semanticscholar +1 more source