Results 91 to 100 of about 2,636 (208)

Design, synthesis and anticonvulsant activity of some new 6,8-halo-substituted-2H-[1,2,4]triazino[5,6-b]indole-3(5H)-one/-thione and 6,8-halo-substituted 5-methyl-2H-[1,2,4]triazino[5,6-b]indol-3(5H)-one/-thione [PDF]

, 2014
A new series of 6,8-halo-substituted-2H-[1,2,4]triazino[5,6-b]indole-3(5H)-one/-thione and 6,8-halo-substituted 5-methyl-2H-[1,2,4]triazino[5,6-b]indol-3(5H)-one/-thione (5a-5l) were designed and synthesized keeping in view of the structural ...
Jain, Sandeep, Kumar, Rajeev, Roy, R. K., Singh, Hariram, Singh, Tejendra   +4 more
core  

Nucleophilic Substitution of Nitro Group in Dihydroazole[5,1-c][1,2,4]triazines [PDF]

, 2019
This work was supported by the Russian Foundation for Basic Research, project # 19-33 ...
Drokin, R. A., Rusinov, V. L., Tufyakov, D. V., Ulomsky, E. N., Voinkov, E. K.   +4 more
core   +1 more source

Novel 5-Substituted 2-(Aylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl)benzenesulfonamides: Synthesis, Molecular Structure, Anticancer Activity, Apoptosis-Inducing Activity and Metabolic Stability

Molecules, 2016
A series of novel 5-substituted 2-(arylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl) benzenesulfonamide derivatives 27–60 have been synthesized by the reaction of aminoguanidines with an appropriate phenylglyoxal hydrate in glacial acetic acid.
Beata Żołnowska, Jarosław Sławiński, Aneta Pogorzelska, Krzysztof Szafrański, Anna Kawiak, Grzegorz Stasiłojć, Mariusz Belka, Szymon Ulenberg, Tomasz Bączek, Jarosław Chojnacki   +9 more
doaj   +1 more source

Determination of "structure-activity" relationship based on analysis of possible biological transformations of the "Triazavirin" drug [PDF]

, 2013
Разработаны удобные методы получения некоторых продуктов возможных биотрансформаций препарата «Триазавирин», а также исследована биологическая активность этих соединений.
Medvedeva, N. R., Медведева, Н. Р.   +1 more
core  

Two mutually complementary synthetic approaches towards 3-substituted 3,4-disubstituted and 1-(2-pyridyl)-substituted isoquinolines

Chimica Techno Acta, 2018
Two mutually complementary synthetic approaches towards 3- and 3,4-disubstituted 1-(2-pyridyl) isoquinolines were studied. The aryne-based method was successfully used for the obtaining of the corresponding the 3-cyano-1-(2-pyridyl)isoquinolines in one ...
I. L. Nikonov, D. S. Kopchuk, A. F. Khasanov, A. P. Krinochkin, E. S. Starnovskaya, Ya. K. Shtaiz, M. I. Savchuk, O. S. Tanya, G. V. Zyryanov, V. L. Rusinov, O. N. Chupakhin   +10 more
doaj   +1 more source

Homogeneous and Heterogeneous Approaches to 1,2,4-Triazine-Accelerated Copper-Catalyzed Azide-Alkyne Cycloadditions [PDF]

, 2011
Over the last decade, the domain of click chemistry has grown exponentially and has significantly impacted the fields of organic synthesis, medicinal chemistry, molecular biology, and materials science. The ideal model of a click reaction has become the
Prince, Ashleigh Lauren
core   +1 more source

Isoxazolyl-Derived 1,4-Dihydroazolo[5,1-c][1,2,4]Triazines: Synthesis and Photochemical Properties. [PDF]

Molecules, 2023
Sadchikova EV, Safronov NE, Beliaev NA, Nenajdenko VG, Belskaya NP.   +4 more
europepmc   +1 more source

The activity of pyrazolo[4,3-e][1,2,4]triazine and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulphonamide derivatives in monolayer and spheroid breast cancer cell cultures

Journal of Enzyme Inhibition and Medicinal Chemistry
In the last decade, an increasing interest in compounds containing pyrazolo[4,3-e][1,2,4]triazine moiety is observed. Therefore, the aim of the research was to synthesise a novel sulphonyl pyrazolo[4,3-e][1,2,4]triazines (2a, 2b) and pyrazolo[4,3-e ...
Anna Szymanowska, Dominika Radomska, Robert Czarnomysy, Mariusz Mojzych, Katarzyna Kotwica-Mojzych, Krzysztof Bielawski, Anna Bielawska   +6 more
doaj   +1 more source

A Facile Synthesis of Pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidine and Pyrido[2′,3′:3,4]pyrazolo[5,1-c][1,2,4]triazine Bearing a Thiophene Moiety

Journal of Chemistry, 2013
Pyridinone derivative 8 was synthesized and transformed into the respective chloropyridine 9, which was allowed to react with hydrazine hydrate to afford pyrazolo[3,4-b]pyridin-3-amine derivative 11.
Tilal Elsaman, Mohamed Fares, Hatem A. Abdel-Aziz, Mohamed I. Attia, Hazem A. Ghabbour, Kamal M. Dawood   +5 more
doaj   +1 more source

The features of nucleophilic substitution of the nitro group in 4-alkyl-6-nitro-1,2,4-triazolo[5,1-c][1,2,4]triazines

Chimica Techno Acta, 2017
The nucleophilic substitution of the nitro group of 4-alkyl-6-nitro-4,7-dihydro-1,2,4-triazolo[5,1-c][1,2,4]triazine-7-ones on the example of interactionwith morpholine was studied.
E. N. Ulomsky, D. N. Lyapustin, V. V. Fedotov, O. S. El'tsov, I. M. Sapozhnikova, D. N. Kozhevnikov, E. M. Mukhin   +6 more
doaj   +1 more source