Results 61 to 70 of about 35,228 (210)

An intramolecular inverse electron demand Diels–Alder approach to annulated α-carbolines

Beilstein Journal of Organic Chemistry, 2012
Intramolecular inverse electron demand cycloadditions of isatin-derived 1,2,4-triazines with acetylenic dienophiles tethered by amidations or transesterifications proceed in excellent yields to produce lactam- or lactone-fused α-carbolines.
Zhiyuan Ma, Feng Ni, Grace H. C. Woo, Sie-Mun Lo, Philip M. Roveto, Scott E. Schaus, John K. Snyder   +6 more
doaj   +1 more source

Synthesis, Characterization and ِAntimicrobial Activities of Some New Heterocyclic Schiff Bases Derived from Thiocarbohydrazide

Acta Chimica Slovenica, 2016
The reaction of prazolobenzothienopyrimidine-3-carbaldehyde 1 with thiocarbohydrazide afforded the Schiff’s base 3. The latter compound reacted with some electrophilic reagents to give 1,2,4-triazoles 4–6 and 1,2,4-triazines 7–9.
Kamelia El-mahdy, Azza El-Kazak, Mohamed Abdel-Megid, Magdy Seada, Osama Farouk   +4 more
doaj   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Efficient Synthesis of 3,7-Diaryl-1,4-dihydro[1,2,4]triazolo[5,1-c][1,2,4]triazines

, 2012
An efficient and versatile protocol for the synthesis of novel 3,7-diaryl-substituted 1,4-dihydro[1,2,4]triazolo[5,1-c][1,2,4]triazines is described, via alkylation/cyclization of 3,5-dibromo-1H-1,2,4-triazole, followed by Suzuki coupling with ...
S. Dallavalle, S. Aiwale
core   +1 more source

15N-Labelling and structure determination of adamantylated azolo-azines in solution

Beilstein Journal of Organic Chemistry, 2017
Determining the accurate chemical structures of synthesized compounds is essential for biomedical studies and computer-assisted drug design. The unequivocal determination of N-adamantylation or N-arylation site(s) in nitrogen-rich heterocycles ...
Sergey L. Deev, Alexander S. Paramonov, Tatyana S. Shestakova, Igor A. Khalymbadzha, Oleg N. Chupakhin, Julia O. Subbotina, Oleg S. Eltsov, Pavel A. Slepukhin, Vladimir L. Rusinov, Alexander S. Arseniev, Zakhar O. Shenkarev   +10 more
doaj   +1 more source

Synthesis, Characterization, Molecular Docking Study and Biological Evaluation of Novel 1,3,4‐Thiadiazole‐Based Heterocycles as Potential Anticancer and Antioxidant Agents

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
A new cyanoacetohydrazide derivative was developed as a key intermediate to synthesize diverse 1,3,4‐thiadiazole‐based heterocyclic compounds. The synthesized compounds were structurally confirmed. Several compounds demonstrated strong cytotoxic activity against HePG‐2 and MCF‐7 cancer cell lines, with compounds 17, 18, and 13 exceeding the activity of
Nashwa M. El‐Metwaly, Abdulmajeed F. Alrefaei, Hossa F. Alshareef, Samar J. Almehmadi, Fatimah A. Alotaibi, Nadiyah M. Alshammari, Manal S. Ebaid, Hanadi A. Katouah   +7 more
wiley   +1 more source

Enaminones as Building Blocks for the Synthesis of Substituted Pyrazoles with Antitumor and Antimicrobial Activities

Molecules, 2011
Novel N-arylpyrazole-containing enaminones 2a,b were synthesized as key intermediates. Reactions of 2a,b with active methylene compounds in acetic acid in the presence of ammonium acetate afforded substituted pyridine derivatives 5a-d.
Sayed M. Riyadh
doaj   +1 more source

Supramolecularly Directed Confined Crystallization of Lamellar Carbon Nitride for Efficient Photocatalytic Hydrogen Generation

Advanced Energy Materials, Volume 16, Issue 22, 10 June 2026.
ABSTRACT Sustainable hydrogen generation through water splitting is key to realizing a future hydrogen economy. In this study, we achieved molecular‐level control over self‐assembled supramolecular complexes of cyanuric acid and 3‐amino 1,2,4 triazole (AT) monomers. This was coupled with molten‐salt‐assisted thermal polymerization in a eutectic mixture
Nithinraj Panangattu Dharmarajan, Mohammed Fawaz, Jae‐Hun Yang, Matej Huš, Xuan Minh Chau Ta, Ayona K. Jose, Vibin Perumalsamy, Aathira M. Sadanandan, CI Sathish, Blaž Likozar, Byoung‐Hwa Lee, Chung‐Hwan Jeon, Antonio Tricoli, Ajayan Vinu   +13 more
wiley   +1 more source

Synthesis of 3,4-dihydro-1,8-naphthyridin-2(1H)-ones via microwave-activated inverse electron-demand Diels–Alder reactions

Beilstein Journal of Organic Chemistry, 2014
Substituted 3,4-dihydro-1,8-naphthyridin-2(1H)-ones have been synthesized with the inverse electron-demand Diels–Alder reaction from 1,2,4-triazines bearing an acylamino group with a terminal alkyne side chain.
Salah Fadel, Youssef Hajbi, Mostafa Khouili, Said Lazar, Franck Suzenet, Gérald Guillaumet   +5 more
doaj   +1 more source

Corn response to biological products and a nitrification inhibitor

Agrosystems, Geosciences &Environment, Volume 9, Issue 2, June 2026.
Abstract Atmospheric nitrogen (N2) is converted into ammonia (NH3), a form that plants can use, through biological nitrogen (N) fixation by various microorganisms and bacterial genera. This study assessed the field performance of three biological N‐fixing products, or biostimulants (BS), including Gluconacetobacter diazotrophicus (BS1), Klebsiella ...
Rose M. Paul, Gurbir Singh, Kelly A. Nelson, Gurpreet Kaur   +3 more
wiley   +1 more source