Results 41 to 50 of about 29,220 (210)
, 2016 Intermolecular inverse electron demand cycloadditions of 2-substituted imidazoles with various 1,2,4-triazines produced both imidazo[4,5-c]pyridines (3-deazapurines) and pyrido[3,2-d]pyrimid-4-ones (8-deazapteridines).
Zhao-Kui Wan (2004907) +2 more
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Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines
, 2021 Novel 3,3′-disubstituted-5,5′-bi(1,2,4-triazine) compounds with potent in vitro activity against Plasmodium falciparum parasites were recently discovered.
Beveridge, Julia G +14 more
core +1 more source
Ring Cleavage of Some Bicylic Compounds Derived from 1,2,4-Triazine [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 1995 Ring cleavage occurred when 1,2,4-triazino-1,2,4-triazines (3), (4) and (5) were treated with concentrated hydrochloric acid to yield N-substituted triazines (7) and (8). These confirm the given configuration assigned to the isomeric triazinotriazines. 6-
Majid M. Heravi +2 more
doaj
Molecules, 2022 A series of new α-(N-biphenyl)-substituted 2,2′-bipyridines were obtained through the combination of the ipso-nucleophilic aromatic substitution of the C5-cyano group, aza-Diels–Alder and Suzuki cross-coupling reactions, starting from 5-cyano-1,2,4 ...
Ekaterina S. Starnovskaya +9 more
doaj +1 more source
Arylation of 1,2,4-triazines in the presence of AlCl3 [PDF]
, 2014 This paper presents a method for introducing toluene and bromobenzene moieties into 1,2,4-triazines as an alternative to cross-coupling reactions. It is demonstrated that the C=N bond of a wide range of 1,2,4-triazines undergoes addition of arenes in the
Egorov, I. N.
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Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone. [PDF]
Org Biomol Chem, 2012 The intramolecular Staudinger-aza-Wittig reaction is used for a general synthesis of 1,2,5,6-tetrahydro-1,2,4-triazines, a structural motif reported for the natural product noelaquinone.
Cao L +4 more
europepmc +2 more sources
Copper- and Silver-Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five- and Six-Membered Heterocycles. [PDF]
ChemistryThis review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
George J, Oh K.
europepmc +2 more sources
A Regioselective Approach to 5-Substituted-3-amino-1,2,4-triazines
, 2016 Nucleophilic displacement of readily available α,α-dibromoketones with excess morpholine gave the corresponding ketoaminals, which upon condensation with aminoguanidine in MeOH in the presence of AcOH afforded 5-substituted-3-amino-1,2,4-triazines in >95%
Paul N. Devine (1831207) +5 more
core +1 more source
, 2017 A new, three-step, telescoped reaction sequence for the regioselective conversion of N-tosyl hydrazones and aziridines to 3,6-disubstituted and 3,5,6-trisubstituted 1,2,4-triazines is described. The process involves an efficient nucleophilic ring opening
Lorène Crespin (3748822) +4 more
core +1 more source
Molecules, 2005 Inverse electron demand Diels-Alder reaction of functionalized 5,5’-bi-1,2,4- triazines with bicyclo[2.2.1]hepta-2,5-diene in boiling p-cymene leads to a range of 6,6’- disubstituted-2,2’-bipyridines in good yield.
D. Branowska
doaj +1 more source