Results 21 to 30 of about 35,228 (210)

Synthesis of functionalized imidazo[4,5-e]thiazolo[3,2-b]triazines by condensation of imidazo[4,5-e]triazinethiones with DMAD or DEAD and rearrangement to imidazo[4,5-e]thiazolo[2,3-c]triazines

Beilstein Journal of Organic Chemistry, 2021
Two series of functionalized imidazothiazolotriazine derivatives were synthesized via the condensation of imidazo[4,5-e]-1,2,4-triazine-3-thiones with acetylenedicarboxylic acid dimethyl and diethyl esters (DMAD and DEAD) and subsequent base-catalyzed ...
Alexei N. Izmest’ev, Dmitry B. Vinogradov, Natalya G. Kolotyrkina, Angelina N. Kravchenko, Galina A. Gazieva   +4 more
doaj   +1 more source

Discovery of 5,6-diaryl-1,2,4-triazines hybrids as potential apoptosis inducers. [PDF]

Eur J Med Chem, 2017
A series of 5,6-diaryl-1,2,4-triazines hybrids bearing a 1,2,3-triazole linker were synthesized by molecular hybridization strategy and evaluated for antiproliferative activity against three selected cancer cell lines (MGC-803, EC-109 and PC-3).
Fu DJ, Song J, Hou YH, Zhao RH, Li JH, Mao RW, Yang JJ, Li P, Zi XL, Li ZH, Zhang QQ, Wang FY, Zhang SY, Zhang YB, Liu HM.   +14 more
europepmc   +2 more sources

The Reaction of 1,6-Diamino-4-aryl-2-oxo-1,2-dihydropyridine- 3,5-Dicarbonitriles with Certain Electrophilic Agents

Chemistry Proceedings, 2023
The reaction of 1,6-diamino-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles, which are easily available through the reaction of cyanoacetohydrazide with arylmethylene malononitriles, with ninhydrin leads to the formation of novel dihydroindeno[1,2-e]pyrido[
Alexei A. Dolganov, Alexandra R. Chikava, Victor V. Dotsenko   +2 more
doaj   +1 more source

The discovery of pyridinium 1,2,4-triazines with enhanced performance in bioconjugation reactions. [PDF]

Chem Sci, 2017
A novel class of pyridinium 1,2,4-triazines with excellent properties for use in bioconjugation reactions was discovered from a systematic kinetic study.
Siegl SJ, Dzijak R, Vázquez A, Pohl R, Vrabel M.   +4 more
europepmc   +2 more sources

Metal-free [2 + 1 + 3] Cycloaddition of Trifluoroacetaldehyde NSulfonylhydrazones with Hexahydro-1,3,5-triazines Leading to Trifluoromethylated 2,3,4,5-Tetrahydro-1,2,4-triazines

, 2022
A transition-metal-free [2 + 1 + 3] cycloaddition of trifluoroacetaldehyde N-sulfonylhydrazone and hexahydro-1,3,5-triazine was described. This operationally simple protocol provides a general synthesis of diverse trifluoromethylated 2,3,4,5-tetrahydro-1,
Qihao Jin, Zhongxue Fang, Zhongxue Fang (1651942), Yongquan Ning, Yongquan Ning (1608853), Xinyu Wang (341591), Xinyu Wang, Qihao Jin (11878717)   +7 more
core   +1 more source

Eco-friendly plant growth and development regulators on the basis of derivatives 1,2,4-triazines [PDF]

BIO Web of Conferences, 2021
The article considers the application of plant growth and development regulators, in particular, derivatives of asymmetric triazines. A method for obtaining hexahydro-1,2,4-triazinone-3 is given.
Builova E.A., Mazitova A.K., Aminova G.K., Zaripov I.I., Alibakova A.H.   +4 more
doaj   +1 more source

Synthesis and pharmacological evaluation of new fluorine substituted pyrimido[1,2-b][1,2,4]triazines and [1,3,5]-triazino-[1,2-b][1,2,4]triazines derived as CDK2 potential inhibitors [PDF]

, 2020
New fluorine-substituted polyfunctional pyrimido-[1,2-b]-[1,2,4]triazines and [1,3,5]-triazino[1,2-b]-[1,2,4]triazines were synthesized via the reaction between 3-amino-6-(2-aminophenyl)-1,2,4-triazin-5(2H)-one with polyfunctional oxygen/sulfur/nitrogen ...
Alotaibi, Fatimah, Bakhotmah, Dina
core   +1 more source

Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives

Molecules, 2020
This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-e][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-e][1,2,4]triazolo[4,3-b][1,2,4]triazines and pyrazolo[4,3-e ...
Zofia Bernat, Anna Szymanowska, Mateusz Kciuk, Katarzyna Kotwica-Mojzych, Mariusz Mojzych   +4 more
doaj   +1 more source

Bioactive Pyrrolo[2,1-f][1,2,4]triazines: Synthesis, Molecular Docking, In Vitro Cytotoxicity Assay and Antiviral Studies

Chemistry, 2023
A series of 2,4-disubstituted pyrrolo[2,1-f][1,2,4]triazines containing both aryl and thienyl substituents were synthesized by exploiting the 1,3-cycloaddition reaction of N(1)-ethyl-1,2,4-triazinium tetrafluoroborates with dimethyl ...
Nataliya N. Mochulskaya, Svetlana K. Kotovskaya, Ilya I. Butorin, Mikhail V. Varaksin, Valery N. Charushin, Vladimir L. Rusinov, Yana L. Esaulkova, Alexander V. Slita, Polina A. Ilyina, Vladimir V. Zarubaev   +9 more
doaj   +1 more source

Dienophilicity of Imidazole in Inverse Electron Demand Diels−Alder Reactions. 4. Intermolecular Reactions with 1,2,4-Triazines

, 2016
Intermolecular inverse electron demand cycloadditions of 2-substituted imidazoles with various 1,2,4-triazines produced both imidazo[4,5-c]pyridines (3-deazapurines) and pyrido[3,2-d]pyrimid-4-ones (8-deazapteridines).
Zhao-Kui Wan (2004907), Brian R. Lahue (1427578), John K. Snyder (331112)   +2 more
core   +2 more sources