Combinatorial approach to the synthesis of substituted 1,2,4-triazines
Chimica Techno Acta, 2017 This article describes a convenient and easy method of substitution of the nitrile group in 5-cyano-1,2,4-triazines with the aim of obtaining of libraries of substituted 1,2,4-triazines (about 500 compounds).
D. N. Kozhevnikov, V. N. Kozhevnikov
doaj +1 more source
Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives
Molecules, 2020 This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-e][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-e][1,2,4]triazolo[4,3-b][1,2,4]triazines and pyrazolo[4,3-e ...
Zofia Bernat +4 more
doaj +1 more source
Cycloalkenopyridines by ring transformations of diazines and triazines [PDF]
, 2008 This paper is a short review on the synthesis of 2,3-cycloalkenopyridines and 3,4-cycloalkenopyridines by inter- and intra-molecular ...
Plas, H.C., van der
core +3 more sources
Chemistry, 2023 A series of 2,4-disubstituted pyrrolo[2,1-f][1,2,4]triazines containing both aryl and thienyl substituents were synthesized by exploiting the 1,3-cycloaddition reaction of N(1)-ethyl-1,2,4-triazinium tetrafluoroborates with dimethyl ...
Nataliya N. Mochulskaya +9 more
doaj +1 more source
Long-range 1H-15N J couplings providing a method for direct studies of the structure and azide-tetrazole equilibrium in a series of azido-1,2,4-triazines and azidopyrimidines [PDF]
, 2013 The selectively 15N labeled azido-1,2,4-triazine 2*A and azidopyrimidine 4*A were synthesized by treating hydrazinoazines with 15N-labeled nitrous acid.
Arseniev, A. S. +6 more
core +1 more source
Chimica Techno Acta, 2017 A convenient method for the obtaining of 3,6-diaryl-1,2,4-triazines substituted with residues of higher alcohols in the position of C5 via the ipso-substitution of cyano group in under the solvent free conditions was reported.
A. P. Krinochkin +9 more
doaj +1 more source
Synthesis, antibacterial activity and cytotoxicity of new fused pyrazolo[1,5-a]pyrimidine and pyrazolo[5,1-c][1,2,4]triazine derivatives from new 5-aminopyrazoles [PDF]
, 2013 New 5-aminopyrazoles 2a–c were prepared in high yields from the reaction of known α,α-dicyanoketene-N,S-acetals 1a–c with hydrazine hydrate under reflux in ethanol.
Adnan, Siti Noor Adnalizawati +5 more
core +1 more source
Metal Acetylides in Cycloaddition Reactions [PDF]
, 2017 This review highlights recent advances in the synthesis of (hetero)aromatic systems via cycloaddition reactions of alkynylmetals with dienes and dipoles.
Comas-Barceló, J., Harrity, J.P.A.
core +1 more source
Molecules, 2010 Arylhydrazonomalononitriles 1a,b react with phenylhydrazine to yield amidrazones 2a,b that cyclize to give 2-aryl-5-phenylhydrazono-2,5-dihydro-[1,2,4]-triazine-6-carbonitriles 5a,b upon reaction with dimethylformamide dimethylacetal (DMFDMA).
Hamad Mohamed Al-Matar +3 more
doaj +1 more source
Spin-spin coupling constants 13C-15N and 1H-15N in the investigation of azido-tetrazole tautomerism in a series of 2-azidopyrimidines [PDF]
, 2013 A new method was developed for the investigation of an azido-tetrazole equilibrium based on using a complex analysis of 13C-15N and 1H-15N spin-spin coupling constants.
Arseniev, A. S. +6 more
core +1 more source