A convenient synthetic approach to 5-(het)arylhydrazine substituted 1,2,4-triazines
A convenient synthesis of 1,2,4-triazines bearing the moieties of (hetero)arylhydrazines at the position of C5 of the 1,2,4-triazine core is reported.
A. P. Krinochkin +6 more
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Expedient synthesis of 1,2,4-triazinyl substituted benzo[c]coumarins via double oxidation strategy
Herein, we report a convenient one-pot synthesis of 1,2,4-triazinyl derivatives of benzocoumarins. The proposed approach consists in the nucleophilic addition of tetrahydrobenzo annulated dimethoxycoumarin to 1,2,4-triazines followed by double oxidation ...
Ramil F. Fatykhov +6 more
doaj +1 more source
Two series of functionalized imidazothiazolotriazine derivatives were synthesized via the condensation of imidazo[4,5-e]-1,2,4-triazine-3-thiones with acetylenedicarboxylic acid dimethyl and diethyl esters (DMAD and DEAD) and subsequent base-catalyzed ...
Alexei N. Izmest’ev +4 more
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The reaction of 1,6-diamino-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles, which are easily available through the reaction of cyanoacetohydrazide with arylmethylene malononitriles, with ninhydrin leads to the formation of novel dihydroindeno[1,2-e]pyrido[
Alexei A. Dolganov +2 more
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The combination of pyrazole and 1,2,4-triazole fragments in one structure makes it possible to achieve some success in creating potential biologically active compounds. Various factors contribute to this process.
S. O. Fedotov, A. S. Hotsulia
doaj +1 more source
Eco-friendly plant growth and development regulators on the basis of derivatives 1,2,4-triazines [PDF]
The article considers the application of plant growth and development regulators, in particular, derivatives of asymmetric triazines. A method for obtaining hexahydro-1,2,4-triazinone-3 is given.
Builova E.A. +4 more
doaj +1 more source
Copper- and Silver-Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five- and Six-Membered Heterocycles. [PDF]
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
George J, Oh K.
europepmc +2 more sources
Predicting Solid-State Heats of Formation of Newly Synthesized Polynitrogen Materials by Using Quantum Mechanical Calculations [PDF]
We present density functional theory level predictions and analysis of the basic properties of newly synthesized high-nitrogen compounds together with 3,6-bis(2H-tetrazol-5-yl)-1,2,4,5-tetrazine (BTT) and 3,3′-azobis(6-amino-1,2,4,5-tetrazine) (DAAT ...
Abou-Rachid, H. +5 more
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3-Methylsulfanyl-5-phenyl-1,2,4-triazine [PDF]
In the molecule of the title compound, C10H9N3S, the dihedral angle between the triazine and phenyl rings is 11.77 (7)°. In the crystal, molecules are linked by π–π stacking interactions [centroid–centroid distances = 3.7359 (3) and 3.7944 (4) Å], forming layers parallel to thebcplane.
Salha Hamri +4 more
openaire +3 more sources
Iridium(iii) complexes of 1,2,4-triazines as potential bioorthogonal reagents: metal coordination facilitates luminogenic reaction with strained cyclooctynes [PDF]
In this paper we describe unprecedented Ir(III) complexes of 5-(2-pyridyl)-1,2,4-triazine and their reactivity towards the strained cyclooctyne BCN. The coordination of a 1,2,4-triazine ring to an iridium(III) ion drastically increases the speed of the ...
Deary, Michael +4 more
core +1 more source

