Combinatorial approach to the synthesis of substituted 1,2,4-triazines [PDF]
Chimica Techno Acta, 2017 This article describes a convenient and easy method of substitution of the nitrile group in 5-cyano-1,2,4-triazines with the aim of obtaining of libraries of substituted 1,2,4-triazines (about 500 compounds).
D. N. Kozhevnikov, V. N. Kozhevnikov
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Molecules, 2010 Arylhydrazonomalononitriles 1a,b react with phenylhydrazine to yield amidrazones 2a,b that cyclize to give 2-aryl-5-phenylhydrazono-2,5-dihydro-[1,2,4]-triazine-6-carbonitriles 5a,b upon reaction with dimethylformamide dimethylacetal (DMFDMA).
Hamad Mohamed Al-Matar +3 more
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A convenient synthetic approach to 5-(het)arylhydrazine substituted 1,2,4-triazines [PDF]
Chimica Techno Acta, 2020 A convenient synthesis of 1,2,4-triazines bearing the moieties of (hetero)arylhydrazines at the position of C5 of the 1,2,4-triazine core is reported.
A. P. Krinochkin +6 more
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Synthesis and properties of 3-(ethylthio)-9-methyl-6-(alkylthio)pyrazolo[1,5-d][1,2,4]triazolo[3,4-f][1,2,4]triazines [PDF]
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022 The combination of pyrazole and 1,2,4-triazole fragments in one structure makes it possible to achieve some success in creating potential biologically active compounds. Various factors contribute to this process.
S. O. Fedotov, A. S. Hotsulia
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(Hetero)Arene Ring-Fused [1,2,4]Triazines
MolbankSynthetic access to a five (hetero)arene ring-fused 3-phenyl[1,2,4]triazines is described. The resulting compounds were characterized via 1H and 13C NMR, IR, UV–vis spectroscopy and HRMS.
Mahshid Teymouri +2 more
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The synthesis of 1,2,4-triazines bearing the residues of higher alcohols in the 5-position via the ipso-substitution of cyano group under the solvent-free conditions [PDF]
Chimica Techno Acta, 2017 A convenient method for the obtaining of 3,6-diaryl-1,2,4-triazines substituted with residues of higher alcohols in the position of C5 via the ipso-substitution of cyano group in under the solvent free conditions was reported.
A. P. Krinochkin +9 more
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A new convenient synthesis of 3-hetaryl-pyrazolo[5,1-c][1,2,4]triazines [PDF]
Journal of Advanced Research, 2012 Reactions of enaminones 2 with diazotized 5-amino-3-phenylpyrazole provide a convenient route to 3-[(4,5-disubstituted-pyrazol-3-yl)carbonyl]-pyrazolo[5,1-c][1,2,4]triazines.
Ahmad S. Shawali
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Regio- and Diastereoselective 1,3-Dipolar Cycloadditions of 1,2,4-Triazin-1-ium Ylides: a Straightforward Synthetic Route to Polysubstituted Pyrrolo[2,1-f][1,2,4]triazines. [PDF]
ACS Omega, 2022 A synthetic strategy to pyrrolo[2,1-f][1,2,4]triazines is reported. We show that various synthetically easily accessible 1,2,4-triazines can be efficiently alkylated under mild conditions to provide the corresponding 1-alkyl-1,2,4-triazinium salts ...
Galeta J +3 more
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4-Hydroxy-3-nitro-1,4-dihydrotriazolo[5,1-c][1,2,4]triazines: synthesis, antiviral activity, and electrochemical characteristics. [PDF]
Russ Chem Bull, 2022 A new method for preparation of 4-hydroxy-3-nitro-1,4-dihydrotriazolo[5,1-c][1,2,4]-triazines using 1-nitro-2-morpholinoethylene and 3-diazo-1,2,4-triazoles is proposed.
Drokin RA +9 more
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Expedient synthesis of 1,2,4-triazinyl substituted benzo[c]coumarins via double oxidation strategy
Chimica Techno Acta, 2023 Herein, we report a convenient one-pot synthesis of 1,2,4-triazinyl derivatives of benzocoumarins. The proposed approach consists in the nucleophilic addition of tetrahydrobenzo annulated dimethoxycoumarin to 1,2,4-triazines followed by double oxidation ...
Ramil F. Fatykhov +6 more
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