Revisiting the Synthesis of Functionally Substituted 1,4-Dihydrobenzo[e][1,2,4]triazines [PDF]
Molecules, 2022 A series of novel 1,4-dihydrobenzo[1,2,4][e]triazines bearing an acetyl or ester moiety as a functional group at the C(3) atom of the 1,2,4-triazine ring were synthesized.
Margarita A. Epishina +2 more
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First Synthesis of 3-Glycopyranosyl-1,2,4-Triazines and Some Cycloadditions Thereof [PDF]
Molecules, 2022 C-glycopyranosyl derivatives of six-membered heterocycles are scarcely represented in the chemical literature and the title 3-glycopyranosyl-1,2,4-triazines are completely unknown. In this paper, the first synthesis of this compound class is accomplished
Éva Bokor +6 more
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A Universal Method for the Synthesis of new Heterocyclic Systems: Pyrimido[2,1‐f][1,2,4]triazines [PDF]
ChemistryOpenThe synthesis of pyrimido[2,1‐f][1,2,4]triazines was performed in four steps. Compounds obtained by acylation of the starting amino esters of thieno[2,3‐b]pyridines were reacted with various amines.
Samvel N. Sirakanyan +7 more
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Strain-promoted reaction of 1,2,4-triazines with bicyclononynes. [PDF]
Chemistry, 2015 AbstractStrain‐promoted inverse electron‐demand Diels–Alder cycloaddition (SPIEDAC) reactions between 1,2,4,5‐tetrazines and strained dienophiles, such as bicyclononynes, are among the fastest bioorthogonal reactions. However, the synthesis of 1,2,4,5‐tetrazines is complex and can involve volatile reagents.
Horner KA, Valette NM, Webb ME.
europepmc +6 more sources
Synthesis of imidazo[4,5-e][1,3]thiazino[2,3-c][1,2,4]triazines via a base-induced rearrangement of functionalized imidazo[4,5-e]thiazolo[2,3-c][1,2,4]triazines [PDF]
Beilstein Journal of Organic Chemistry, 2023 A series of imidazo[4,5-e][1,3]thiazino[2,3-c][1,2,4]triazines was synthesized via a cascade sequence of hydrolysis and skeletal rearrangement of imidazo[4,5-e]thiazolo[2,3-c][1,2,4]triazin-7(8H)-ylidene)acetic acid esters in methanol upon treatment with
Dmitry B. Vinogradov +4 more
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Combinatorial approach to the synthesis of substituted 1,2,4-triazines
Chimica Techno Acta, 2017 This article describes a convenient and easy method of substitution of the nitrile group in 5-cyano-1,2,4-triazines with the aim of obtaining of libraries of substituted 1,2,4-triazines (about 500 compounds).
D. N. Kozhevnikov, V. N. Kozhevnikov
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Molecules, 2010 Arylhydrazonomalononitriles 1a,b react with phenylhydrazine to yield amidrazones 2a,b that cyclize to give 2-aryl-5-phenylhydrazono-2,5-dihydro-[1,2,4]-triazine-6-carbonitriles 5a,b upon reaction with dimethylformamide dimethylacetal (DMFDMA).
Hamad Mohamed Al-Matar +3 more
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Direct synthesis of 5-arylethynyl-1,2,4-triazines via direct CH-functionalization [PDF]
Chimica Techno Acta, 2020 An efficient synthetic approach towards 5-arylethynyl-1,2,4-triazines via direct C-H-functionalization of 5-H-1,2,4-triazines in reaction with lithium acetylenes is reported.
M. I. Savchuk +9 more
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Synthesis and anticancer evaluation of some novel pyrimido[5,4-e][1,2,4]triazines and pyrazolo[3,4-d]pyrimidine using DMF-DMA as methylating and cyclizing agent [PDF]
Chemistry Central Journal, 2018 Background Described a series of main target compounds pyrimido[5,4-e][1,2,4]triazines is obtained via condensation of 6-hydrazinyluracil with different aromatic aldehydes to give the hydrazones followed by nitrosation with HNO2 then intramolecular ...
Samar A. El-Kalyoubi
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A convenient synthetic approach to 5-(het)arylhydrazine substituted 1,2,4-triazines [PDF]
Chimica Techno Acta, 2020 A convenient synthesis of 1,2,4-triazines bearing the moieties of (hetero)arylhydrazines at the position of C5 of the 1,2,4-triazine core is reported.
A. P. Krinochkin +6 more
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