Results 51 to 60 of about 14,929 (209)

Small-molecule APOBEC3G DNA cytosine deaminase inhibitors based on a 4-amino-1,2,4-triazole-3-thiol scaffold. [PDF]

ChemMedChem, 2013
APOBEC3G (A3G) is a single‐stranded DNA cytosine deaminase that functions in innate immunity against retroviruses and retrotransposons. Although A3G can potently restrict Vif‐deficient HIV‐1 replication by catalyzing excessive levels of G→A hypermutation,
Olson ME, Li M, Harris RS, Harki DA.
europepmc   +2 more sources

Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis

European Journal of Organic Chemistry, Volume 29, Issue 32, 24 August 2026.
In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley   +1 more source

4-phenyl-5-((pyrimidin-2-ylthio)methyl)-1,2,4-triazole-3-thiol as a platform for the synthesis of unsymmetrical disulfides

Current issues in pharmacy and medicine: science and practice
The article discusses effective methods for the synthesis of unsymmetrical disulfides, which are important in the development of new bioactive molecules, pharmaceuticals, and materials for bioconjugation and systemic release.
Yu. V. Karpenko, M. Panasenko
semanticscholar   +1 more source

Structural Modifications of Nonsteroidal Anti‐Inflammatory Drugs (NSAIDs): New Horizons in Antimicrobial Drug Discovery

Archiv der Pharmazie, Volume 359, Issue 8, August 2026.
This review provides a comprehensive analysis of the molecular modifications applied to NSAIDs to develop novel antimicrobial agents. By focusing on structural changes and their impact on biological activity, the study highlights innovative strategies to combat the global challenge of antimicrobial resistance.
Ebru Koçak Aslan, Ayşe Karagüzel, Miyase Gözde Gündüz   +2 more
wiley   +1 more source

The results of determining the indicators of the morphological composition of the blood of animals and individual biochemical indicators using a potential drug with a mixture of two active compounds: 4-((5-(decylthio)-4-methyl-4H-1,2,4-triazole-3-yl)methyl)morpholine and 5-(2-fluorophenyl)-4-((4-bromophenyl)ylidene)amino-1,2,4-triazole-3-thiol in milk thistle seed oil

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022
The introduction of new domestic highly effective and safe medicines into medical and veterinary practice is an important task of modern pharmaceutical science.
M. V. Ohloblina, I V. Bushuieva, V. V. Parchenko   +2 more
doaj   +1 more source

Dimethyl‐, Diethyl‐, and Propylene Carbonates: An Emerging Class of Green Solvents for Organic Synthesis

The Chemical Record, Volume 26, Issue 8, August 2026.
This review highlights recent advances in the use of organic carbonates, dimethyl carbonate (DMC), diethyl carbonate (DEC), and propylene carbonate (PC), as solvents in organic synthesis. Based on over seventy studies from the past 6 years, it shows their application in different organic reaction types, emphasizing their role in safer and more ...
Gabriela T. Quadros, Livia C. L. Valente, Thiago Barcellos, Daniela Hartwig, Laura Abenante, Eder J. Lenardão   +5 more
wiley   +1 more source

Auf dem Weg zu chromoselektiven Transformationen in biologischen Systemen: Perspektiven und Herausforderungen

Angewandte Chemie, Volume 138, Issue 31, 27 July 2026.
Die Kontrolle biologischer Systeme mit organischen Chromophoren hat sich zu einer vielversprechenden Strategie entwickelt und findet Anwendung von der chemischen Biologie bis hin zur Medizin. Die Komplexität von In‐vivo‐Systemen lässt sich jedoch nicht mit nur einer einzigen Lichtwellenlänge adäquat abbilden.
Nadja A. Simeth
wiley   +1 more source

The search of new biologically active compounds with antibacterial and antifungal activity among 1,2,4-triazole-3-thiol derivatives with the remnants of thiophene

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
The resistance of microorganisms to antimicrobial and antifungal drugs is still an actual issue in the modern world. Therefore, one of the possible ways to solve this problem is the creation of new drugs.
V. O. Salionov, O. I. Panasenko, Ye. G. Knysh, O. M. Kamyshnyi   +3 more
doaj   +1 more source

Toward Chromoselective Transformations in Biological Systems: Perspectives and Challenges

Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.
Controlling biological systems with small‐molecule chromophores has evolved into a powerful strategy and is applied from chemical biology to medicine. However, the complexity of in vivo systems cannot be matched by a single wavelength of light. Developing methods to combine and individually control multiple chromophores is crucial.
Nadja A. Simeth
wiley   +1 more source

Synthesis and physical properties of esters of 2-[5-((theophylline-7ʹ-yl)methyl)-4-R-1,2,4-triazole-3-ylthio]acetic acid

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
The large synthetic potential and high biological potential in the series of 1,2,4-triazole derivatives cause favorable conditions for the search for new biologically active substances.
A. S. Gotsulya
doaj   +1 more source