Results 61 to 70 of about 14,929 (209)

Synthesis and acute toxicity of new S-derivatives (1,2,4-triazole-3(2H)-yl)methyl) thiopyrimidines

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2023
In the literature, there is insufficient information on the synthesis of compounds in a series of pyrimidine-2-thiol derivatives containing a five-membered nitrogen-containing heterocyclic fragment; at the same time, there are a sufficient number of ...
Yu. V. Karpenko, O. I. Panasenko, S. M. Kulish, A. V. Domnich   +3 more
doaj   +1 more source

Oligonucleotides Post‐Synthetic Modifications: An Overview of Clickable Nucleoside Phosphoramidites Suitable for Solid‐Phase Synthesis

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Clickable nucleoside phosphoramidites can be incorporated into oligonucleotides via solid‐phase synthesis (SPOS), enabling rapid and site‐specific post‐functionalization using bioorthogonal reactions. This review highlights their design, synthetic accessibility, and SPOS incorporation requirements, along with the kinetics and efficiency of post ...
Sébastien Depienne, Alexandra Bristiel, Dominique Urban, Dominique Guianvarc’h   +3 more
wiley   +1 more source

Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors

Acta Pharmaceutica, 2020
Middle East respiratory syndrome coronavirus (MERS-CoV) had emerged and spread because of the worldwide travel and inefficient healthcare provided for the infected patients in several countries.
Zaher Nashwa Hafez, Mostafa Mohammed Ismail, Altaher Abdullah Yousef   +2 more
doaj   +1 more source

Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges

The Chemical Record, Volume 26, Issue 7, July 2026.
Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley   +1 more source

Synthesis and structure of new 4-amino-5-(2-R1-phenyl)-1,2,4-triazole-3-thiol alkilderivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
Chemistry of heterocyclic systems is a separate branch of organic chemistry with a long history and future prospects. The ring system of 1,2,4-triazole continuously attracts the interest of chemists, pharmacologists and pharmacists in finding ...
Ye. S. Pruglo
doaj   +1 more source

1,2,4-Triazole-3-thiol-protected silver-nanoparticles as a platform for ECE electrochemical reaction

Electrochemistry Communications, 2017
Abstract Incorporation of “green chemistry” principles into nanotechnology has become one of the key subjects for nanoscience researches. In this work, we report an electrochemical reaction with ECE mechanism on the surface of 1,2,4-triazole-3-thiol-protected silver nanoparticles (TATAgNPs) via electrochemical oxidation of catechol in the presence ...
Hamid Salehzadeh, Davood Nematollahi, Ali Hajian   +2 more
openaire   +1 more source

Electrophilic Iodination of Heterocyclic Compounds. Recent Advances 2008–2025: Part II

European Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.
Electrophilic iodination using molecular iodine and iodide sources represents an efficient approach for accessing valuable iodinated organic compounds. This review highlights recent advances in the iodination of heterocyclic compounds from 2008 to 2025, emphasizing the role of heteroaryl iodides as important synthetic intermediates for biologically ...
Njomza Ajvazi, Stojan Stavber
wiley   +1 more source

Electrochemical behaviour of 5-benzyl-4-( 4' -methylphenyl)-4H-1,2,4- triazole-3-thiol by voltammetry

, 2007
Canakkale Onsekiz Mart University, Science and Arts Faculty, Department of Chemistry, 17100 Canakkale/Turkey E-mail: ydilgin@comu.edu.tr, ydilgin@yahoo.com Fax: 90-2862-180533 Department of Chemistry, Faculty of Arts and Sciences, Firat University, 23119 Elazig/Turkey Ege University, Science Faculty, Department of Chemistry, 35100 Bornova-lzmir/Turkey ...
Dilgin Y., Koparir M., Çetin A., Cansiz A., Yilmaz S., Giray D.   +5 more
openaire   +5 more sources

Vacuolization as a Novel Approach to Cancer Therapy

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak, Noor Hussein, Veronica Piedra, Saloni Malla, Chandrabose Karthikeyan, Haneen Amawi, Harish Rajak, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +9 more
wiley   +1 more source

New Insights into 1,2,4-Triazole-3-Thiol Chemistry: Synthesis and Tuberculostatic Activity

International Journal of Environmental Sciences
Background: Tuberculosis (TB), a formidable global health crisis, relentlessly claims countless lives annually, perpetuating widespread morbidity and mortality. The dire need for groundbreaking treatments has ignited fervent research into innovative therapeutic paradigms. Materials and Methods: This pioneering study embarked on synthesizing an array of
Pooja Koganole, Pooja Gouda, Sushmita Hiremath, Sagar Shiraguppi, Suresh Honnalli, Pradeepkumar M. Ronad, Sanket Hosamani   +6 more
openaire   +1 more source