Results 91 to 100 of about 84,221 (197)

Acute toxicity of 5-(furan-2-yl, 2-metylfuran-3-yl)-4-amino-1,2,4-triazole-3-thiol alkyl derivatives

Zaporožskij Medicinskij Žurnal, 2017
The purpose of our work was the further exploration of the new 5-(furan-2-yl, 2-metylfuran-3-yl)-4-amino-1,2,4-triazole-3-thiol alkyl derivatives’ acute toxicity, setting some patterns of alkyl substituents influence by the Sulfur atom on the acute ...
D. M. Danilchenko, V. V. Parchenko
doaj   +1 more source

Amidine Syntheses from Classic to Contemporary for Medicinal Lead Compounds and Natural Products

European Journal of Organic Chemistry, EarlyView.
A revolution is underway in the synthesis of amidines with new methods unlocking complex, highly substituted amidines or closely related derivatives such as N‐sulfonyl amidines. This review surveys recent advances in amidines and related compounds, including methods to install them and bioactive molecules prominently featuring the amidine functionality.
Wyatt R. Swift‐Ramirez, Gregory A. Weiss   +1 more
wiley   +1 more source

Application of Surface‐Enhanced Raman Spectroscopy (SERS) in Histamine Analysis of Aquatic Products: Principles, Applications, Challenges, and Prospects

Food Frontiers, EarlyView.
This review introduces the significant advantages of SERS detection of histamine, which is accurate, non‐destructive, and fast. By critically analyzing the current challenges, we propose future directions for industrializing the application of SERS in histamine detection.
Xingying Jiang, Ruizhi Yang, Jia Liang, Bin Zheng, Meiling Chen, Bin Zhang, Tao Han, Yadong Zhao, Soottawat Benjakul   +8 more
wiley   +1 more source

Synthesis, Characterization, and Bioactivity of Quinoxaline Thiazolotriazoles

Journal of Heterocyclic Chemistry, EarlyView.
Quinoxaline thiazolotriazole target molecules with antibacterial, antitubercular and antidiabetic activity. ABSTRACT A total of 10 quinoxaline thiazolo[2,3‐c][1,2,4]triazole hybrid molecules were synthesized in a four‐step synthetic protocol. Six of these compounds are reported here for the first time.
Silungile Mhlongo, Sibusiso Senzani, Shahidul Islam, Kolawole Olofinsan, Moganavelli Singh, Nirasha Nundkumar, Sithabile Mokoena, Rajshekhar Karpoormath, Neil A. Koorbanally   +8 more
wiley   +1 more source

Evaluation of antioxidant activity of 1,2,4-triazole derivatives in the initiation of free radical processes

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
The activation of lipid free radical oxidation is a key stage in the development of many diseases and can lead to the emergence of related complications.
I. M. Bilai, V. I. Dariy, A. V. Khilkovets, A. I. Bilai, I. F. Duiun   +4 more
doaj   +1 more source

Navigating Solute Carrier Transporters—A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization

Medicinal Research Reviews, EarlyView.
ABSTRACT Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in fundamental physiological processes such as nutrient uptake, neurotransmitter signaling, and drug transport ...
Majlen A. Dilweg, Tracie Widjaja, Adriaan P. IJzerman, Daan van der Es   +3 more
wiley   +1 more source

Synthesis, physical-chemical properties of 2-((4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-yl)thio)acetohydrazides

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
Aim. Analysis of the scientific literature over the past decade has shown that large synthetic possibilities towards creating new and effective drug substances have heterocyclic compounds, in particular the derivatives of 1,2,4-triazole.
O. A. Suhak, O. I. Panasenko, Ye. G. Knysh   +2 more
doaj   +1 more source

Role of the Oxidation State in Cobalt Chemical Mechanical Planarization

MetalMat, EarlyView.
Control over the reduction potential and diffusion behavior of the oxidizer allows precise modulation of cobalt surface oxidation, leading to the formation of a thin amorphous cobalt (II) oxide layer. This oxide layer improves removal rate and surface planarity in cobalt chemical mechanical planarization compared to thick crystalline cobalt (II and III)
Ganggyu Lee, Yehwan Kim, Myungju Woo, Sumin Hong, Hongjun Park, Giha Lee, Taeseup Song, Ungyu Paik   +7 more
wiley   +1 more source

Stability Constants of Metal Complexes of 1,2,4-Triazoles

, 1991
Department of Chemistry. S. V. University, Tirupati-517 502 Manuscript received 21 May 1990, revised 2 December 1991, accepted 6 December 1991 The present study reports the stability constants of the metal complexes using bivalent Mn, Fe, Co, Ni, Cu and Zn with 4-amino-3-(methylphenyl)-5- mercapto-1 ,2,4-triazole (1), 4-amino-3-phenyl-5-mercapto-1,2,4 ...
V. V. RAMANA, K. YAMUNA, K. SARASWATHI
openaire   +1 more source

Synthesis and Anticancer Potential of New Benzimidazole Theranostic

ChemistryOpen, EarlyView.
Recent advances have highlighted benzimidazole's importance in anticancer drug discovery. A novel series of benzimidazole analogs is designed and synthesized, with V7 showing broad anticancer activity and selectivity, possibly linked to SIRT2 inhibition.
Sahani Sandalima Uthumange, Muhammad Azri Faiz bin Abdul Zaki, Keng Yoon Yeong   +2 more
wiley   +1 more source