Results 11 to 20 of about 84,221 (197)

Review of the research on the influence of different functional substituents of new 1,2,4-triazole derivatives on the compounds biological properties

Фармацевтичний журнал, 2022
Today, 1,2,4-triazole derivatives are a promising class of organic compounds. This is caused, first of all, by the possibility of various chemical modifications of the 1,2,4-triazole fragment due to the addition of typical pharmacophores, which ...
M. V. Ogloblina, I. V. Bushueva, V. V. Parchenko   +2 more
doaj   +1 more source

Preparation and antitumor effects of 4-amino-1,2,4-triazole Schiff base derivative

Journal of International Medical Research, 2020
Objectives The purpose of this paper was to synthesize 4-amino-1,2,4-triazole Schiff base derivative and to evaluate its antitumor activity. Methods 2,4,6-Tris (4-formylphenoxy)-1,3,5-triazine was synthesized by nucleophilic substitution with reaction of
Guo-wei Jiang, Qing Chang, Dong-yu Liang, Yu-ting Zhang, Yong-jun Meng, Qing-qing Yi   +5 more
doaj   +1 more source

Antimicrobial and antifungal activity of new 4-(5-((5-(alkylthio)-4-R-4H-1,2,4-triazole-3-yl)thio)-1H-1,2,4-triazole-3-yl)pyridines

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020
The resistance of such strains as Staphylococcus aureus, Escherichia coli extends to many antimicrobial drugs. This problem can be solved by searching for new drugs with high bactericidal and antifungal action.
Ye. O. Karpun, N. M. Polishchuk
doaj   +1 more source

Synthesis and Screening of New [1,3,4]Oxadiazole, [1,2,4]Triazole, and [1,2,4]Triazolo[4,3-b][1,2,4]triazole Derivatives as Potential Antitumor Agents on the Colon Carcinoma Cell Line (HCT-116)

ACS Omega, 2021
New derivatives of [1,3,4]oxadiazole-2-thione and triazole-3-thione were synthesized through the cyclocondensation of dicarbonyl ester 2 with phenyl hydrazine followed by hydrazinolysis to give the corresponding hydrazide, which reacted with carbon ...
El-sayed M. Abdelrehim
semanticscholar   +1 more source

Diuretic activity of 3-(5-bromfuran-2-yl)-4-r-(4h)-1,2,4-triazole-5-thione, their S-derivatives and 2-(5-bromfuran-2-yl)-5-r'-thiazolo[3,2-b][1,2,4]triazole-6(5h)-ones

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015
The aim of study was to investigate diuretic activity of 1,2,4-triazole derivatives which contain С5 atom 5-bromfuran-2-yl substituent in the 1,2,4-triazole nucleus, and to establish interrelation between chemical structure and diuretic action of 1,2,4 ...
Ye. S. Pruglo, A. S. Gotsulya, O. I. Panasenko, Ye. G. Knysh   +3 more
doaj   +1 more source

Potential energetic salts of 5,5′-methylenedi(4H-1,2,4-triazole-3,4-diamine) cation: Synthesis, characterization and detonation performance

Energetic Materials Frontiers, 2022
1,2,3-Triazole and 1,2,4-triazole have been vigorously used in energetic materials research. Among these two, 1,2,4-triazole has been a widely used backbone in designing new energetic materials with improved performance.
Ramling S Mathpati, Abhishek Kumar Yadav, Vikas D Ghule, Srinivas Dharavath   +3 more
doaj   +1 more source

Antiviral activity of 1,2,4-triazole derivatives (microreview)

Chemistry of Heterocyclic Compounds, 2021
The microreview summarizes data published since 2015 on the antiviral properties and synthesis of compounds containing the 1,2,4-triazole ring.
N. V. Simurova, O. Maiboroda
semanticscholar   +1 more source

The search for new 4-amino-5-methyl-4H-1,2,4-triasole-3-thion derivatives with diuretic activity

Zaporožskij Medicinskij Žurnal, 2018
1,2,4-Triazole derivatives have been widely used in medical practice due to their wide spectrum of biological activities and low toxicity, as they have 1,2,4-triazole cycle in their structure.
T. V. Kravchenko
doaj   +1 more source

Synthesis and biological evaluation of heterocyclic 1,2,4-triazole scaffolds as promising pharmacological agents

BMC Chemistry, 2020
Background Triazole is an important heterocyclic moiety that occupies a unique position in heterocyclic chemistry, due to its large number of biological activities. It exists in two isomeric forms i.e.
M. Kumari, Sumit Tahlan, B. Narasimhan, K. Ramasamy, S. Lim, S. A. Shah, V. Mani, S. Kakkar   +7 more
semanticscholar   +1 more source

1,2,4-Triazoles. VII. Methylation of 1,2,4-triazoles.

Chemical and Pharmaceutical Bulletin, 1976
AbstractMethylierung von 1,2,4‐Triazol und dessen symmetrisch 3,5‐disubst.
Yukinori Hisazumi, Masayuki Uda, Koji Sato, Seiju Kubota   +3 more
openaire   +4 more sources