Results 11 to 20 of about 1,566 (134)

Synthesis of N-Aryl-3,5-dichloro-4H-1,2,6-thiadiazin-4-imines from 3,4,4,5-Tetrachloro-4H-1,2,6-thiadiazine

Organic Letters, 2015
Condensation of 3,4,4,5-tetrachloro-4H-1,2,6-thiadiazine with a range of anilines gave 22 N-aryl-3,5-dichloro-4H-1,2,6-thiadiazin-4-imines in 43-96% yields. The scope and limitations of this condensation are briefly investigated. Furthermore, mono- and bis-substitution of the C-3 and C-5 chlorines of 3,5-dichloro-N-phenyl-4H-1,2,6-thiadiazin-4-imine by
Kalogirou, Andreas S., Manoli, Maria, Koutentis, Panayiotis Andreas, Kalogirou, Andreas S., Manoli, Maria, Koutentis, Panayiotis Andreas   +5 more
core   +6 more sources

Novel Mono-Substituted 4H-1,2,6-Thiadiazines with Antioxidant and Anti-Lipoxygenase Activities. [PDF]

Int J Mol Sci
Τhe synthesis of a novel series of mono-substituted 4H-1,2,6-thiadiazine derivatives was reported, aiming at enhancing antioxidant and lipoxygenase inhibitory activities via pharmacophore combination. The compounds were prepared from 3,5-dichloro-4H-1,2,6-thiadiazin-4-one and 2-(3,5-dichloro-4H-1,2,6-thiadiazin-4-ylidene)malononitrile.
Charissopoulos E, Koutentis PA, Kalogirou AS, Pontiki E.   +3 more
europepmc   +5 more sources

6-Amino-4-phenylpyrrolo[2,3-c][1,2,6]thiadiazine-5-carbonitrile

Molbank
The reaction of 2-(3-chloro-5-phenyl-4H-1,2,6-thiadiazin-4-ylidene)malononitrile with ammonia in anhydrous THF, at ca. 20 °C, for 24 h, gave 6-amino-4-phenylpyrrolo[2,3-c][1,2,6]thiadiazine-5-carbonitrile in 95% yield. The product was characterized by 1H
Andreas S. Kalogirou, Andreas Kourtellaris, Panayiotis A. Koutentis   +2 more
doaj   +2 more sources

Synthesis of 5′-Chlorospiro(benzo[d][1,3]dioxole-2,4′-[1,2,6]thiadiazin)-3′-amine and 10-Chloro-1,4-dioxa-8-thia-7,9-diazaspiro[4.5]deca-6,9-dien-6-amine

Molbank
Reactions of 3′,5′-dichlorospiro(benzo[d][1,3]dioxole-2,4′-[1,2,6]thiadiazine) or 6,10-dichloro-1,4-dioxa-8-thia-7,9-diazaspiro[4.5]deca-6,9-diene with ammonia in MeCN, at ca.
Andreas S. Kalogirou, Panayiotis A. Koutentis   +1 more
doaj   +2 more sources

Synthesen bicyclischer 1,2,6‐Thiadiazine

Archiv der Pharmazie, 1981
Abstractα‐Aminosäureamide aus der Pyrrol‐ Furan‐ und Thiophen‐Reihe werden zu neuen Schwefelheterocyclen umgesetzt. Die Stabilität dieser Verbindungen wird untersucht.
Wolfgang Offermann, Kurt Eger, Hermann J. Roth   +2 more
openaire   +2 more sources

5-Cyano-7-(2-hydroxyphenyl)-4-[(2-hydroxyphenyl)amino]pyrrolo[2,3-c][1,2,6]thiadiazin-6(7H)-iminium Chloride Hydrate

Molbank
Reaction of 2-(3,5-dichloro-4H-1,2,6-thiadiazin-4-ylidene)malononitrile with sodium 2-aminophenolate (1.5 equiv.) in anhydrous THF at ca. 0–20 °C afforded the known 4-chlorobenzo[5,6][1,4]oxazino[2,3-c][1,2,6]thiadiazine in 76% yield.
Andreas S. Kalogirou, Andreas Kourtellaris, Panayiotis A. Koutentis   +2 more
doaj   +2 more sources

Synthesis of Oligomeric 4H‐1,2,6‐Thiadiazines

ChemistrySelect, Volume 10, Issue 7, February 19, 2025.
The study reports the synthesis of oligomeric amino‐4H‐1,2,6‐thiadiazines that were efficiently obtained in high yields through C─N coupling reactions. Three analogs with terminal phenyl groups, containing up to four thiadiazine units, were prepared, as well as two amino‐substituted bisthiadiazine oligomers.
Andreas S. Kalogirou, Andreas Kourtellaris, Panayiotis A. Koutentis   +2 more
wiley   +2 more sources

Synthesis of 1,2,6-Thiadiazin 1,1-Dioxide Derivatives as Trypanocidal Agents [PDF]

Molecules, 2000
It describes the synthesis of new 1,2,6-Thiadiazin 1,1-dioxide derivatives using condensation of the Knoevenagel type. The products are evaluated in vitro as trypanocidal agents.
H. Cerecetto, R. Di Maio, G. Seoane, C. Ochoa, S. Muelas, A. Gómez-Barrio   +5 more
openaire   +3 more sources

Synthesis of 3-[(2-Ethylhexyl)amino]-5-phenyl-4H-1,2,6-thiadiazin-4-one and 3-[(2-Ethylhexyl)amino]-5-[(4-oxo-5-phenyl-4H-1,2,6-thiadiazin-3-yl)amino]-4H-1,2,6-thiadiazin-4-one

Molbank
Suzuki–Miyaura coupling of 3-chloro-5-[(2-ethylhexyl)amino]-4H-1,2,6-thiadiazin-4-one with phenylboronic acid, at ca. 100 °C, gave 3-[(2-ethylhexyl)amino]-5-phenyl-4H-1,2,6-thiadiazin-4-one in 69% yield.
Andreas S. Kalogirou, Panayiotis A. Koutentis   +1 more
doaj   +2 more sources

The Photochemical Mediated Ring Contraction of 4<i>H</i>-1,2,6-Thiadiazines To Afford 1,2,5-Thiadiazol-3(2<i>H</i>)-one 1-Oxides. [PDF]

Org Lett, 2023
Funding: E.B. and C.G.T. are grateful to Heriot-Watt University and the EPSRC CRITICAT Centre for Doctoral Training (E.B. Ph.D. Studentship: EP/L016419/1, C.G.T Ph.D. Studentship: EP/LO14419/1) for funding and training. C.G.T.
Broumidis E, Thomson CG, Gallagher B, Sotorríos L, McKendrick KG, Macgregor SA, Paterson MJ, Lovett JE, Lloyd GO, Rosair GM, Kalogirou AS, Koutentis PA, Vilela F.   +12 more
europepmc   +2 more sources