Results 11 to 20 of about 64 (60)

3-Chloro-5-(3-n-hexylthien-2-yl)-4H-1,2,6-thiadiazin-4-one

Molbank, 2019
Stille coupling of 5-chloro-4-oxo-4H-1,2,6-thiadiazin-3-yl trifluoromethanesulfonate (7) with tributyl(3-n-hexylthien-2-yl)stannane and Pd(Ph3P)2Cl2 in PhMe at ca. 20 °C, for 24 h gave 3-chloro-5-(3-n-hexylthien-2-yl)-4H-1,2,6-thiadiazin-4-one (9) with a
Andreas S. Kalogirou, Panayiotis A. Koutentis   +1 more
doaj   +1 more source

3,5-Bis[5-(thiazol-2-yl)thien-2-yl]-4H-1,2,6-thiadiazin-4-one

Molbank, 2019
Stille coupling of 3,5-bis(5-bromothien-2-yl)-4H-1,2,6-thiadiazin-4-one (10) with 2-(tri-n-butylstannyl)thiazole and Pd(Ph3P)2Cl2 in PhMe, at ca. 110 °C, for 2 h, gave 3,5-bis[5-(thiazol-2-yl)thien-2-yl]-4H-1,2,6-thiadiazin-4-one (9) in 81% yield.
Andreas S. Kalogirou, Panayiotis A. Koutentis   +1 more
doaj   +1 more source

5,5′-Thiobis(3-methoxy-4H-1,2,6-thiadiazin-4-one)

Molbank, 2019
The reaction of 3-chloro-5-methoxy-4H-1,2,6-thiadiazin-4-one (9) with Na2S·9H2O (0.5 equiv) in tetrahydrofuran (THF) at ca. 20 °C for 20 h gives 5,5′-thiobis(3-methoxy-4H-1,2,6-thiadiazin-4-one) (10) in a 44% yield as yellow needles.
Andreas S. Kalogirou, Panayiotis A. Koutentis   +1 more
doaj   +1 more source

Synthesis and Physico-Chemical Properties of 6- and 7-Monosubstituted Pyrazino|2,3-c̱|-1,2,6-thiadiazine 2,2-Dioxides

Pteridines, 1990
Selective procedures for the synthesis of 6- and of 7-monosubstituted derivatives of pyrazinoI2,3-c̱|-1 ,2,6- thiadiazine 2,2-dioxide and their reactions with N-bromosuccinimide are reported.
Alkorta Ibon, Goya Pilar, Paez Juan Antonio, Pfleiderer Wolfgang   +3 more
doaj   +1 more source

Synthesis of 5′-Chlorospiro(benzo[d][1,3]dioxole-2,4′-[1,2,6]thiadiazin)-3′-amine and 10-Chloro-1,4-dioxa-8-thia-7,9-diazaspiro[4.5]deca-6,9-dien-6-amine

Molbank
Reactions of 3′,5′-dichlorospiro(benzo[d][1,3]dioxole-2,4′-[1,2,6]thiadiazine) or 6,10-dichloro-1,4-dioxa-8-thia-7,9-diazaspiro[4.5]deca-6,9-diene with ammonia in MeCN, at ca.
Andreas S. Kalogirou, Panayiotis A. Koutentis   +1 more
doaj   +1 more source

6-Amino-4-phenylpyrrolo[2,3-c][1,2,6]thiadiazine-5-carbonitrile

Molbank
The reaction of 2-(3-chloro-5-phenyl-4H-1,2,6-thiadiazin-4-ylidene)malononitrile with ammonia in anhydrous THF, at ca. 20 °C, for 24 h, gave 6-amino-4-phenylpyrrolo[2,3-c][1,2,6]thiadiazine-5-carbonitrile in 95% yield. The product was characterized by 1H
Andreas S. Kalogirou, Andreas Kourtellaris, Panayiotis A. Koutentis   +2 more
doaj   +1 more source

Synthesis of 3-[(2-Ethylhexyl)amino]-5-phenyl-4H-1,2,6-thiadiazin-4-one and 3-[(2-Ethylhexyl)amino]-5-[(4-oxo-5-phenyl-4H-1,2,6-thiadiazin-3-yl)amino]-4H-1,2,6-thiadiazin-4-one

Molbank
Suzuki–Miyaura coupling of 3-chloro-5-[(2-ethylhexyl)amino]-4H-1,2,6-thiadiazin-4-one with phenylboronic acid, at ca. 100 °C, gave 3-[(2-ethylhexyl)amino]-5-phenyl-4H-1,2,6-thiadiazin-4-one in 69% yield.
Andreas S. Kalogirou, Panayiotis A. Koutentis   +1 more
doaj   +1 more source

2-[3,5-Bis(5-bromothien-2-yl)-4H-1,2,6-thiadiazin-4-ylidene]-malononitrile

Molbank
Bromination of 2-[3,5-di(thien-2-yl)-4H-1,2,6-thiadiazin-4-ylidene]-malononitrile with N-bromosuccinimide in THF, at ca. 20 °C for 24 h gave 2-[3,5-bis(5-bromothien-2-yl)-4H-1,2,6-thiadiazin-4-ylidene]-malononitrile in 82% yield.
Andreas S. Kalogirou, Andreas Kourtellaris, Panayiotis A. Koutentis   +2 more
doaj   +1 more source

The Photochemical Mediated Ring Contraction of 4<i>H</i>-1,2,6-Thiadiazines To Afford 1,2,5-Thiadiazol-3(2<i>H</i>)-one 1-Oxides. [PDF]

Org Lett, 2023
Broumidis E, Thomson CG, Gallagher B, Sotorríos L, McKendrick KG, Macgregor SA, Paterson MJ, Lovett JE, Lloyd GO, Rosair GM, Kalogirou AS, Koutentis PA, Vilela F.   +12 more
europepmc   +1 more source

Synthesis and Evaluation of Novel 1,2,6-Thiadiazinone Kinase Inhibitors as Potent Inhibitors of Solid Tumors. [PDF]

Molecules, 2021
Kalogirou AS, East MP, Laitinen T, Torrice CD, Maffuid KA, Drewry DH, Koutentis PA, Johnson GL, Crona DJ, Asquith CRM.   +9 more
europepmc   +1 more source