Synthesis and Evaluation of Novel 1,2,6-Thiadiazinone Kinase Inhibitors as Potent Inhibitors of Solid Tumors. [PDF]
Molecules, 2021 A focused series of substituted 4H-1,2,6-thiadiazin-4-ones was designed and synthesized to probe the anti-cancer properties of this scaffold. Insights from previous kinase inhibitor programs were used to carefully select several different substitution ...
Kalogirou AS +9 more
europepmc +3 more sources
Synthesis of 3,4-Dihydropyrimidin(thio)one Containing Scaffold: Biginelli-like Reactions. [PDF]
Pharmaceuticals (Basel), 2022 The interest in 3,4-dihydropyrimidine-2(1H)-(thio)ones is increasing every day, mainly due to their paramount biological relevance. The Biginelli reaction is the classical approach to reaching these scaffolds, although the product diversity suffers from ...
Sánchez-Sancho F +6 more
europepmc +3 more sources
Benzothiadiazine dioxide human cytomegalovirus inhibitors: Synthesis and antiviral evaluation of main heterocycle modified derivatives [PDF]
, 2013 The benzothiadiazine dioxide derivatives are potent non-nucleoside human cytomegalovirus (HCMV) inhibitors. As part of our comprehensive structure-activity relationship (SAR) study of these compounds, we have now proposed structural modifications on the ...
Bruno, Ana M. +6 more
core +2 more sources
Nitrogen-Containing Molecules: Natural and Synthetic Products Including Coordination Compounds [PDF]
, 2022 A total of 16 original research articles. Contributions from 10 countries from 3 continents. Organic synthesis towards novel heterocyclic compounds.
core +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2020 The title compound, C15H22N4O5S, was prepared via alkylation of 3-(chloromethyl)-5-(pentan-3-yl)-1,2,4-oxadiazole in anhydrous dioxane in the presence of triethylamine. The thiadiazine ring has an envelope conformation with the S atom displaced by 0.4883
Alexandre V. Ivachtchenko +5 more
doaj +1 more source
Catalyzed Methods to Synthesize Pyrimidine and Related Heterocyclic Compounds [PDF]
, 2023 This review covers articles published in the period from 2010 to mid-2022 on synthetic advances in the formation of pyrimidine and related heterocyclic compounds.
Algarra, Manuel +5 more
core
Photoactive materials enabled by and for emerging synthetic technologies [PDF]
, 2022 In recent years there has been a significant increase in the development and commercialisation of new synthetic tools and technologies, which offer significant advantages compared to traditional round-bottomed flask chemistry.
Broumidis, Emmanouil
core
3-Chloro-5-(3-n-hexylthien-2-yl)-4H-1,2,6-thiadiazin-4-one
Molbank, 2019 Stille coupling of 5-chloro-4-oxo-4H-1,2,6-thiadiazin-3-yl trifluoromethanesulfonate (7) with tributyl(3-n-hexylthien-2-yl)stannane and Pd(Ph3P)2Cl2 in PhMe at ca. 20 °C, for 24 h gave 3-chloro-5-(3-n-hexylthien-2-yl)-4H-1,2,6-thiadiazin-4-one (9) with a
Andreas S. Kalogirou +1 more
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3,5-Bis[5-(thiazol-2-yl)thien-2-yl]-4H-1,2,6-thiadiazin-4-one
Molbank, 2019 Stille coupling of 3,5-bis(5-bromothien-2-yl)-4H-1,2,6-thiadiazin-4-one (10) with 2-(tri-n-butylstannyl)thiazole and Pd(Ph3P)2Cl2 in PhMe, at ca. 110 °C, for 2 h, gave 3,5-bis[5-(thiazol-2-yl)thien-2-yl]-4H-1,2,6-thiadiazin-4-one (9) in 81% yield.
Andreas S. Kalogirou +1 more
doaj +1 more source
5,5′-Thiobis(3-methoxy-4H-1,2,6-thiadiazin-4-one)
Molbank, 2019 The reaction of 3-chloro-5-methoxy-4H-1,2,6-thiadiazin-4-one (9) with Na2S·9H2O (0.5 equiv) in tetrahydrofuran (THF) at ca. 20 °C for 20 h gives 5,5′-thiobis(3-methoxy-4H-1,2,6-thiadiazin-4-one) (10) in a 44% yield as yellow needles.
Andreas S. Kalogirou +1 more
doaj +1 more source