Results 31 to 40 of about 1,673 (99)

Synthesis of N‑Aryl-3,5-dichloro‑4H‑1,2,6-thiadiazin-4-imines from 3,4,4,5-Tetrachloro‑4H‑1,2,6-thiadiazine

, 2015
Condensation of 3,4,4,5-tetrachloro-4H-1,2,6-thiadiazine with a range of anilines gave 22 N-aryl-3,5-dichloro-4H-1,2,6-thiadiazin-4-imines in 43–96% yields. The scope and limitations of this condensation are briefly investigated.
Maria Manoli (1339620), Panayiotis A. Koutentis (1278807), Andreas S. Kalogirou (1546180)   +2 more
core   +1 more source

Novel bronchodilators: Synthesis, transamination reactions, and pharmacology of a series of pyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxides

, 2000
The synthesis, pharmacological evaluation, and structure-activity relationships of a new class of bronchodilator agents, derivatives of pyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxides are described.
Alkorta, Ibon, Goya, Pilar, Campillo, Nuria E., García-Gómez, Concepción, Páez, Juan A., Pilar Goya, Nuria Campillo, García, Concepción, Ibon Alkorta, Juan A. Páez, Concepción García   +10 more
core   +1 more source

Synthesis of 3-[(2-Ethylhexyl)amino]-5-phenyl-4H-1,2,6-thiadiazin-4-one and 3-[(2-Ethylhexyl)amino]-5-[(4-oxo-5-phenyl-4H-1,2,6-thiadiazin-3-yl)amino]-4H-1,2,6-thiadiazin-4-one

Molbank
Suzuki–Miyaura coupling of 3-chloro-5-[(2-ethylhexyl)amino]-4H-1,2,6-thiadiazin-4-one with phenylboronic acid, at ca. 100 °C, gave 3-[(2-ethylhexyl)amino]-5-phenyl-4H-1,2,6-thiadiazin-4-one in 69% yield.
Andreas S. Kalogirou, Panayiotis A. Koutentis   +1 more
doaj   +1 more source

Synthesis of Oligomeric 4H‐1,2,6‐Thiadiazines

ChemistrySelect, Volume 10, Issue 7, February 19, 2025.
The study reports the synthesis of oligomeric amino‐4H‐1,2,6‐thiadiazines that were efficiently obtained in high yields through C─N coupling reactions. Three analogs with terminal phenyl groups, containing up to four thiadiazine units, were prepared, as well as two amino‐substituted bisthiadiazine oligomers.
Andreas S. Kalogirou, Andreas Kourtellaris, Panayiotis A. Koutentis   +2 more
wiley   +1 more source

Novel Bronchodilators:  Synthesis, Transamination Reactions, and Pharmacology of a Series of Pyrazino[2,3-c][1,2,6]thiadiazine 2,2-Dioxides

, 2016
The synthesis, pharmacological evaluation, and structure−activity relationships of a new class of bronchodilator agents, derivatives of pyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxides are described.
Concepción García (363008), Juan A. Páez (3011922), Ibon Alkorta (537241), Pilar Goya (397723), Nuria Campillo (3011925)   +4 more
core   +1 more source

Entwicklung der Synthesen von N-Heterozyklen, Sulfonimidamiden und einem [$^{125}I$]-markierten PARP-Inhibitor

, 2022
The content of this work is the synthesis of trifluoroethylated 5- and 6-membered N heterocycles by radical trifluoromethylation of vinyl azides. Furthermore, sulfonimidoyl chlorides and their reaction with pyridium N oxides were studied.
Terhorst, Steven
core   +1 more source

5-Cyano-7-(2-hydroxyphenyl)-4-[(2-hydroxyphenyl)amino]pyrrolo[2,3-c][1,2,6]thiadiazin-6(7H)-iminium Chloride Hydrate

Molbank
Reaction of 2-(3,5-dichloro-4H-1,2,6-thiadiazin-4-ylidene)malononitrile with sodium 2-aminophenolate (1.5 equiv.) in anhydrous THF at ca. 0–20 °C afforded the known 4-chlorobenzo[5,6][1,4]oxazino[2,3-c][1,2,6]thiadiazine in 76% yield.
Andreas S. Kalogirou, Andreas Kourtellaris, Panayiotis A. Koutentis   +2 more
doaj   +1 more source

Discovery of 1,1-dioxo-1,2,6-thiadiazine-5-carboxamide derivatives as cannabinoid-like molecules with agonist and antagonist activity

, 2007
A series of new 2-substituted 1,1-dioxo-1,2,6-thiadiazine-5-carboxylate derivatives have been prepared from monosubstituted sulfamides in order to obtain N-substituted 1,1-dioxo-1,2,6-thiadiazine-5-carboxamides as novel cannabinoid derivatives ...
Cano, Carolina, Martín, M. Isabel, Goya, Pilar, Sánchez, Eva, Girón, Rocío, Páez, Juan A.   +5 more
core   +1 more source

On the reactivity of 1H-pyrazino[2,3-c] [1,2,6]thiadiazine 2,2-dioxide and derivatives: Nucleophilic substitution, amination, aldol-type condensation, oxidation, and hydrolysis

, 2013
The reactivity of the 1H-pyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxide system, structurally related to pteridine, was studied, and a number of novel derivatives were synthesized.
Goya, Pilar, Campillo, Nuria E., Páez, Juan A.   +2 more
core   +1 more source

A study of peculiar tautomerism of pyrido[2,3-c][1,2,6]thiadiazine 2,2-dioxide system

, 2013
A systematic study of the tautomerism of 4-amino-1H-pyrido[2,3-c][1,2,6] thiadiazine 2,2-dioxide has been carried out. Thus, the relativity stability of the possible tautomers has been studied in the gas phase by ab initio and functional density theory ...
Montero, C., Campillo, Nuria E., Páez, Juan A.   +2 more
core   +1 more source