Results 41 to 50 of about 1,673 (99)

N,N-Dialkyl-N′-Chlorosulfonyl Chloroformamidines in Heterocyclic Synthesis. Part XIV. Synthesis and Reactivity of the New Benzo[4,5]imidazo[1,2-b][1,2,6]thiadiazine Ring System

, 2018
N,N-Dialkyl-N′-chlorosulfonyl chloroformamidines 1 underwent regioselective reactions with the 1,3-NCC bis-nucleophilic 1H-benzimidazole-2-acetonitriles 4 and related compounds to produce benzo[4,5]imidazo[1,2-b][1,2,6]thiadiazine dioxides 6, 9, 12, and ...
Craig L. Francis, Dylan Innes, Andris J. Liepa, Michael V. Perkins   +3 more
core   +1 more source

Novel arylpyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxides as inhibitors of platelet aggregation. 1. Synthesis and pharmacological evaluation

, 1999
A series of N-1-substituted derivatives of pyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxides bearing aryl groups at the pyrazino moiety have been prepared.
Goya, Pilar, Carrasco, Emilio, Grau, Manuel, Campillo, Nuria E., García-Gómez, Concepción, Páez, Juan A., Pilar Goya, Nuria Campillo, Emilio Carrasco, Manuel Grau, Juan A. Páez, Concepción García   +11 more
core   +1 more source

Isothiazoles .6. Cycloaddition of azides to isothiazole dioxides: Synthesis of thiadiazabicyclo[3.1.0]hexene derivatives and their thermal rearrangement to thiazete dioxides, 1,2,6-thiadiazine dioxides and pyrazoles.

, 1996
3-Diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide (1) was made to react with arylalkyl-and arylazides 2. Cycloadducts 3, which could be isolated in some cases, afforded N-arylalkyl-or N-aryl-thiadiazabicyclo[3.1.0]hexene derivatives 4 through N2-
F. Galletti, P. Roversi, Pocar, D, F. Clerici, D. Pocar, Clerici, F, Galletti, F, Roversi, Pietro, Clerici F., Galletti F., Pocar D., Roversi P.   +11 more
core   +1 more source

Novel arylpyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxides as platelet aggregation inhibitors. 2. Optimization by quantitative structure-activity relationships

, 1999
In the previous paper (Part 1), we described the synthesis and antiplatelet activity of a series of phenyl- and heteroarylpyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxides.
Goya, Pilar, Campillo, Nuria E., Páez, Juan A., Pilar Goya, Nuria Campillo, Juan A. Páez   +5 more
core   +1 more source

Identifying potential candidates for donor-acceptor copolymers on a series of 4H-1,2,6-thiadiazines: An electrochemical approach

, 2013
A series of synthesized small organic molecules based on the 4H-1,2,6-thiadiazine moiety are studied using electrochemistry, to probe their potential as comonomer building blocks for solar-absorbing polymers for organic solar cells.
Choulis, Stelios A., Ioannidou, Heraklidia A., Koutentis, Panayiotis A., Economopoulos, Solon P.   +3 more
core   +1 more source

Una nueva familia de antichagásicos derivados de 2,2-dióxido de imidazo [4,5-c] [1,2,6] tiadiazina [PDF]

, 2009
[EN] Compounds derived from imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxides for use as medicament or pharmaceutical composition for treatment of parasitic diseases, preferably of diseases caused by parasites of the genus Trypanosome, and more preferably ...
Cerecetto, Hugo, Guerra, Ángela, Campillo, Nuria E., Páez, Juan A., González Hormaizteguy, M. M, Cerecetto Meyer, Hugo   +5 more
core  

Design, synthesis, and biological evaluation of novel 4-aminopiperidinyl-linked 3,5-disubstituted-1,2,6-thiadiazine-1,1-dione derivatives as HIV-1 NNRTIs

, 2015
Based on the hybridization of the privileged fragments in DABO and DAPY-typed HIV-1 NNRTIs, a novel series of 4-aminopiperidinyl-linked 3,5-disubstituted-1,2,6-thiadiazine-1,1-dione derivatives were designed, synthesized, and evaluated for their in vitro
Liang, Xin, Zhan, Peng, Huang, Boshi, De Clercq, Erik, Pannecouque, Christophe, Liu, Huiqing, Tian, Ye, Liu, Xinyong, Liu, Tao, Liu, Hong   +9 more
core   +1 more source

Synthesis of (R) and (S)-3-Chloro-5-(3-methylmorpholino)-4H-1,2,6-thiadiazin-4-ones

, 2020
Reaction of 3,5-dichloro-4H-1,2,6-thiadiazin-4-one with (R) and (S)-3-methylmorpholines (2 equiv), in THF, at ca. 20 °C gave (R) and (S)-3-chloro-5-(3-methylmorpholino)-4H-1,2,6-thiadiazin-4-ones in 95 and 97% yields, respectively.
Christopher R. M. Asquith, Panayiotis A. Koutentis, Andreas S. Kalogirou   +2 more
core   +1 more source

Synthesis of Potential SH2 Domain Ligands Containing Phosphate Group Mimics [PDF]

, 2011
This thesis describes the synthesis of two peptidomimetics containing heterocyclicphosphate group mimics. These compounds are based on a potent STAT3 inhibitor andtherefore have the potential of being SH2 domain ligands.
Ware, Nathaniel F.
core  

Design, synthesis, and biological evaluation of novel 3,5-disubstituted-1,2,6-thiadiazine-1,1-dione derivatives as HIV-1 NNRTIs

, 2013
On the basis of structural features, binding mode, and structure-activity relationship studies of two pyrimidine-derived non-nucleoside reverse-transcriptase inhibitors, DABOs, and diaryl pyrimidines, a novel class of 1,2,6-thiadiazine-1,1-dione ...
Zhan, Peng, Pannecouque, Christophe, De Clercq, Erik, Rai, Diwakar, Liu, Huiqing, Tian, Ye, Liu, Xinyong, Balzarini, Jan   +7 more
core   +1 more source