Results 41 to 50 of about 1,566 (134)

Design, synthesis, and biological evaluation of novel 3,5-disubstituted-1,2,6-thiadiazine-1,1-dione derivatives as HIV-1 NNRTIs

, 2013
On the basis of structural features, binding mode, and structure-activity relationship studies of two pyrimidine-derived non-nucleoside reverse-transcriptase inhibitors, DABOs, and diaryl pyrimidines, a novel class of 1,2,6-thiadiazine-1,1-dione ...
Zhan, Peng, Pannecouque, Christophe, De Clercq, Erik, Rai, Diwakar, Liu, Huiqing, Tian, Ye, Liu, Xinyong, Balzarini, Jan   +7 more
core   +1 more source

Design, synthesis, and biological evaluation of novel 4-aminopiperidinyl-linked 3,5-disubstituted-1,2,6-thiadiazine-1,1-dione derivatives as HIV-1 NNRTIs

, 2015
Based on the hybridization of the privileged fragments in DABO and DAPY-typed HIV-1 NNRTIs, a novel series of 4-aminopiperidinyl-linked 3,5-disubstituted-1,2,6-thiadiazine-1,1-dione derivatives were designed, synthesized, and evaluated for their in vitro
Liang, Xin, Zhan, Peng, Huang, Boshi, De Clercq, Erik, Pannecouque, Christophe, Liu, Huiqing, Tian, Ye, Liu, Xinyong, Liu, Tao, Liu, Hong   +9 more
core   +1 more source

Una nueva familia de antichagásicos derivados de 2,2-dióxido de imidazo [4,5-c] [1,2,6] tiadiazina [PDF]

, 2009
[EN] Compounds derived from imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxides for use as medicament or pharmaceutical composition for treatment of parasitic diseases, preferably of diseases caused by parasites of the genus Trypanosome, and more preferably ...
Cerecetto, Hugo, Guerra, Ángela, Campillo, Nuria E., Páez, Juan A., González Hormaizteguy, M. M, Cerecetto Meyer, Hugo   +5 more
core  

Acid-Catalyzed Hydrolysis and Intramolecular Cyclization of NCyano Sulfoximines for the Synthesis of Thiadiazine 1Oxides

, 2022
Herein, we describe a novel approach for the practical synthesis of thiadiazine 1-oxides 10. The first example of an intramolecular cyclization with 2-N-cyano-sulfonimidoyl amides 9 to form the desired thiadiazine 1-oxides 10 was developed.
Seong Jun Park (7388279), Duck-Hyung Lee, Duck-Hyung Lee (1829032), Ji Young Hyun, Ji Young Hyun (1419691), Ye Ji Seo, Ye Ji Seo (11909032), In Seok Oh (11909029), Hwan Jung Lim (2037718), In Seok Oh, Hwan Jung Lim, Seong Jun Park   +11 more
core   +1 more source

Effect of thiadiazine derivatives on intracellular amastigotes of Leishmania amazonensis

, 2004
Current therapy for leishmaniasis is not satisfactory. We describe the in vitro antiproliferative effects of new thiadiazine derivatives against Leishmania amazonensis.
Lianet Monzote Fidalgo, Hortensia Rodríguez Cabrera, Rolando Pérez Pineiro, Pérez Pineiro, Rolando, Monzote Fidalgo, Lianet, Suárez Navarro, Margarita, Margarita Suárez Navarro, Montalvo Álvarez, Ana Margarita, Lisset Fonseca Geigel, Ana Margarita Montalvo Álvarez, Geigel, Lisset Fonseca, Rodríguez Cabrera, Hortensia   +11 more
core   +1 more source

Synthesis and Evaluation of Novel 1,2,6-Thiadiazinone Kinase Inhibitors as Potent Inhibitors of Solid Tumors. [PDF]

Molecules, 2021
Kalogirou AS, East MP, Laitinen T, Torrice CD, Maffuid KA, Drewry DH, Koutentis PA, Johnson GL, Crona DJ, Asquith CRM.   +9 more
europepmc   +1 more source

thiadiazine‐4‐thiones

, 1994
Thiation of N‐(1‐tert‐butyl‐3‐methylpyrazol‐5‐yl)carboxamides 2 with the Lawesson reagent afforded the corresponding thiocarboxamides 3. Heating of 3 in formic acid gave the N‐dealkylated thiocarboxamides 4 which were cyclized into 4H‐pyrazolo[1,5‐c][1,3,
C. B. Vicentini, GIORI, Paolo, P. Giori, VERONESE, Augusto, M. Manfrini, VICENTINI, Chiara Beatrice, S. Guccione, A. C. Veronese, M. Guarneri, GUARNERI, Mario, Guccione S., MANFRINI, Maurizio   +11 more
core   +1 more source

New chemistry of isothiazoles and 1,2,6-thiadiazines

, 2011
This thesis begins with a short introduction on heterocyclic chemistry as well as the known chemistry of isothiazoles and 1,2,6-thiadiazines. The main part is then divided into 3 parts (Chapters 2, 3 and 4 are Part 1, Chapters 5, 6 and 7 are part 2 and part 3 is chapter 8). In the first part, the regioselective dehalogenation of 3,5-dihaloisothiazole-4-
Ioannidou, Heraklidia A., Ioannidou, Heraklidia A.   +1 more
openaire   +1 more source

Fungitoxicity of 6H-Pyrazolo[3,4-c] [1,2,5]thiadiazine 2,2-Dioxides

, 1990
A base‐promoted cyclisation of 4‐nitroso‐5‐benzylsulphonamidopyrazoles (VII) afforded 6H‐pyrazolo[3,4‐c][1,2,5]thiadiazine‐2,2‐dioxides (VIII). They were tested in vitro for antifungal activity against a series of phytopathogenic fungi of different ...
GIORI, Paolo, Poli T., VERONESE, Augusto, VICENTINI, Chiara Beatrice, BRANDOLINI, Vincenzo, GUARNERI, Mario   +5 more
core   +1 more source

Synthesis of 3,4-Dihydropyrimidin(thio)one Containing Scaffold: Biginelli-like Reactions. [PDF]

Pharmaceuticals (Basel), 2022
Sánchez-Sancho F, Escolano M, Gaviña D, Csáky AG, Sánchez-Roselló M, Díaz-Oltra S, Del Pozo C.   +6 more
europepmc   +1 more source