Results 21 to 30 of about 331 (145)

Synthesis and Physico-Chemical Properties of 6- and 7-Monosubstituted Pyrazino|2,3-c̱|-1,2,6-thiadiazine 2,2-Dioxides

Pteridines, 1990
Selective procedures for the synthesis of 6- and of 7-monosubstituted derivatives of pyrazinoI2,3-c̱|-1 ,2,6- thiadiazine 2,2-dioxide and their reactions with N-bromosuccinimide are reported.
Alkorta Ibon, Goya Pilar, Paez Juan Antonio, Pfleiderer Wolfgang   +3 more
doaj   +1 more source

1,2,6-Thiadiazine 1-Oxides: Unsaturated Three-Dimensional S,N-Heterocycles from Sulfonimidamides [PDF]

Organic Letters, 2020
Unprecedented three-dimensional 1,2,6-thiadiazine 1-oxides have been prepared by an aza-Michael-addition/cyclization/condensation reaction sequence starting from sulfonimidamides and propargyl ketones. The products have been further functionalized by standard cross-coupling reactions, selective bromination of the heterocyclic ring, and conversion into ...
Schöbel, Jan-Hendrik, Passia, Marco Thomas, Wolter, Nadja Anna, Puttreddy, Rakesh, Rissanen, Kari, Bolm, Carsten   +6 more
openaire   +4 more sources

Synthesis of 5′-Chlorospiro(benzo[d][1,3]dioxole-2,4′-[1,2,6]thiadiazin)-3′-amine and 10-Chloro-1,4-dioxa-8-thia-7,9-diazaspiro[4.5]deca-6,9-dien-6-amine

Molbank
Reactions of 3′,5′-dichlorospiro(benzo[d][1,3]dioxole-2,4′-[1,2,6]thiadiazine) or 6,10-dichloro-1,4-dioxa-8-thia-7,9-diazaspiro[4.5]deca-6,9-diene with ammonia in MeCN, at ca.
Andreas S. Kalogirou, Panayiotis A. Koutentis   +1 more
doaj   +1 more source

6-Amino-4-phenylpyrrolo[2,3-c][1,2,6]thiadiazine-5-carbonitrile

Molbank
The reaction of 2-(3-chloro-5-phenyl-4H-1,2,6-thiadiazin-4-ylidene)malononitrile with ammonia in anhydrous THF, at ca. 20 °C, for 24 h, gave 6-amino-4-phenylpyrrolo[2,3-c][1,2,6]thiadiazine-5-carbonitrile in 95% yield. The product was characterized by 1H
Andreas S. Kalogirou, Andreas Kourtellaris, Panayiotis A. Koutentis   +2 more
doaj   +1 more source

Synthesis of 3-[(2-Ethylhexyl)amino]-5-phenyl-4H-1,2,6-thiadiazin-4-one and 3-[(2-Ethylhexyl)amino]-5-[(4-oxo-5-phenyl-4H-1,2,6-thiadiazin-3-yl)amino]-4H-1,2,6-thiadiazin-4-one

Molbank
Suzuki–Miyaura coupling of 3-chloro-5-[(2-ethylhexyl)amino]-4H-1,2,6-thiadiazin-4-one with phenylboronic acid, at ca. 100 °C, gave 3-[(2-ethylhexyl)amino]-5-phenyl-4H-1,2,6-thiadiazin-4-one in 69% yield.
Andreas S. Kalogirou, Panayiotis A. Koutentis   +1 more
doaj   +1 more source

2-[3,5-Bis(5-bromothien-2-yl)-4H-1,2,6-thiadiazin-4-ylidene]-malononitrile

Molbank
Bromination of 2-[3,5-di(thien-2-yl)-4H-1,2,6-thiadiazin-4-ylidene]-malononitrile with N-bromosuccinimide in THF, at ca. 20 °C for 24 h gave 2-[3,5-bis(5-bromothien-2-yl)-4H-1,2,6-thiadiazin-4-ylidene]-malononitrile in 82% yield.
Andreas S. Kalogirou, Andreas Kourtellaris, Panayiotis A. Koutentis   +2 more
doaj   +1 more source

2-пиперидино-5-(тиенил-2)- и 2-пиперидино-5-(тиенил-3)-6н-1,3,4-тиадиазины гидробромиды, обладающие антиагрегантным действием [PDF]

, 2012
Изобретение относится к 2-пиперидино-5-(тиенил-2)-6Н-1,3,4-тиадиазинам, гидробромидам (общей формулы I) и 2-пиперидино-5-(тиенил-3)-6Н-1,3,4-тиадиазинам, гидробромидам (общей формулы II), которые обладают антиагрегантным действием.Данные соединения могут
Васильева, Т. М., Макаров, В. А., Перова, Н. М., Русинов, В. Л., Сидорова, Л. П., Чупахин, О. Н.   +5 more
core  

1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) inhibitors [PDF]

, 1983
We demonstrate for the first time that 4H-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4H-1,2,6-thiadiazin-4-one bound to ...
Asquith, Christopher R.M., Godoi, Paulo H., Counago, Rafael M., Laitinen, Tuomo, Scott, John W., Langendorf, Christopher G., Oakhill, Jonathan S., Drewry, David H., Zuercher, William J., Koutentis, Panayiotis A., Willson, Timothy M., Kalogirou, Andreas S.   +11 more
core   +3 more sources

Studies and Synthesis of Syringolin A, Functionalized Thiadiazines, and Thiol Additions to Enones [PDF]

, 2013
Part one of this dissertation describes the formal synthesis of syringolin A. Syringolin A contains a unique 12-membered dipeptide core and has been shown to be a potent irreversible proteasome inhibitor.
Rosenker, Christopher J
core  

Neuartige monomere und polymere stickstoffhaltige Akzeptoren - Synthese, Eigenschaften und Anwendung in der organischen Elektronik [PDF]

, 2015
Im Rahmen der vorliegenden Doktorarbeit wurden verschiedene mono- und polymere Akzeptor- und Donor-Akzeptormaterialien synthetisiert und erfolgreich in organischen Leuchtdioden (OLEDs) als Matrixmaterialien eingesetzt.
Teusch, Claudia
core   +1 more source