Results 21 to 30 of about 7,959 (164)

Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP) [PDF]

, 2014
N-Myristoyltransferase (NMT) is an essential eukaryotic enzyme and an attractive drug target in parasitic infections such as malaria. We have previously reported that 2-(3-(piperidin-4-yloxy)benzo[b]thiophen-2-yl)-5-((1,3,5-trimethyl-1H-pyrazol-4-yl ...
Anthony A. Holder, Anthony J. Wilkinson, Bird C. W., Bissantz C., Bostrom J., Brand S., Brannigan J. A., Böhm H.-J., Delves M., Derbyshire E. R., Desjardins R. E., Dondorp A. M., Dossetter A. G., Dunitz J. D., Edward W. Tate, Emsley P., Evans P., Fidock D. A., Frearson J. A., Goldberg K., Goncalves V., Goncalves V., Griffen E., Hann M. M., Hopkins A. L., Hopkins A. L., James A. Brannigan, Kabsch W., Kaveri Rangachari, Kenny P. W., Keseru G. M., Leeson P. D., Mark D. Rackham, Meister S., Murray C. J. L., Murshudov G. N., Möskes C., Patwardhan P., Phyo A. P., Pino P., Poulin B., Rackham M. D., Rees-Channer R. R., Resh M. D., Ritchie T. J., Robin J. Leatherbarrow, Singh B., Stephan Meister, Tull D., Wager T. T., Waring M. J., Watjen F., Winter G., Wright M. H., Wright M. H., Yu Z., Yung-Chi C., Zhao H.   +57 more
core   +1 more source

Radical Retrosynthesis of Natural Products Enabled by Iron‐Based Reductive Olefin Coupling

Angewandte Chemie Novit, Volume 2, Issue 1, March 2026.
This review highlights iron‐catalyzed reductive olefin coupling (ROC)—a strategy for C─C bond formation driven by metal‐hydride hydrogen atom transfer (MHAT)—as a key tool in natural products synthesis. This review surveys dozens of total syntheses employing ROC‐based strategies, highlighting its power to forge strained rings, quaternary centers, and ...
Griffin L. Barnes, Alex L. Rerick, Phil S. Baran   +2 more
wiley   +1 more source

Dual Acting Polymeric Nano-Aggregates for Liver Cancer Therapy [PDF]

, 2018
Liver cancer treatments are often hindered by poor drug physicochemical properties, hence there is a need for improvement in order to increase patient survival and outlook.
Al-Shakarchi, W, Alsuraifi, A, Curtis, A, Hoskins, C   +3 more
core   +4 more sources

Synthesis and Biological Evaluation of Theophylline Methyl 1,3,4-Oxadiazole as Anticancer Agents [PDF]

, 2020
A series of theophylline methyl 1,3,4-oxadiazole small molecules were obtained via cyclization of theophylline-7-acetohydrazide with different benzoic acids. The compounds (IVa-j) were synthesized and characterized by using conventional methods.
Gopinatha, Vindya K., Mantelingu, K., Raghavan, Sathees C., Rangappa, K. S., Ray, Ujjayinee   +4 more
core   +1 more source

Exploring Novel Nitrofuryl‐1,3,4‐Thiadiazole‐Based Derivatives: Design, Synthesis, and Evaluation of In Vitro Leishmanicidal and Trypanocidal Activity

Archiv der Pharmazie, Volume 359, Issue 3, March 2026.
In a series of substituted 1‐[5‐(5‐nitrofuran‐2‐yl)‐1,3,4‐thiadiazol‐2‐yl]piperidine‐4‐carboxamides evaluated for in vitro antileishmanial and antitrypanosomal activity, compound 18 emerged as the most promising derivative, showing submicromolar anti‐parasitic effects targeting diverse Leishmania and Trypanosoma species and acceptable selectivity ...
Alireza Mousavi, Martina Slapničková, Maryam Norouzbahari, Sarah D'Alessandro, Parham Foroumadi, Fariba Peytam, Federica Perego, Eva Doleželová, Zahra Emamgholipour, Maliheh Barazandeh Tehrani, Seyed Esmaeil Sadat‐Ebrahimi, Elahe Hosseinzadeh, Elmira Meghrazi Ahadi, Loghman Firoozpour, Hamidreza Bijanzadeh, Nicoletta Basilico, Alena Zíková, Alireza Foroumadi   +17 more
wiley   +1 more source

Synthesis, Structural Analysis and Screening of Some Novel 5-Substituted Aryl/Aralkyl-1,3,4-Oxadiazol-2-Yl 4-(Morpholin-4-Ylsulfonyl)Benzyl Sulfides as Potential Antibacterial Agents [PDF]

, 2015
A series of new 5-substituted aryl/aralkyl-1,3,4-oxadiazol-2-yl 4-(morpholin-4-ylsulfonyl)benzyl sulfides 6a-k were synthesized by converting multifarious aryl/aralkyl organic acids 1a-k successively into corresponding esters 2a-k, hydrazides 3a-k and 5 ...
Abbasi, Muhammad Athar, Afzal, Saira, Ahmad, Irshad, Akhtar, Muhammad Nadeem, Gul, Samreen, Nafeesa, Khadija, Rehman, Aziz-ur   +6 more
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Chromaticity Control in Light‐Emitting Electrochemical Cells via Thermally Activated Emission in Assemblies of a BN‐Doped Pyrenyl Hydrocarbon

Advanced Functional Materials, Volume 36, Issue 5, 15 January 2026.
The successful color control in light‐emitting electrochemical cells based on highly emissive green‐emitting BN‐doped polyaromatic hydrocarbon with thermally activated NIR emitting assemblies. Abstract This work outlines the synthesis and photo‐/electro‐luminescent behavior of a new C‐shaped BN‐doped benzenoid hydrocarbon using N‐directed borylation in
Luca M. Cavinato, Marco Franceschini, Laura Caputo, Jean‐Christophe Charlier, Marc de Wergifosse, Davide Bonifazi, Rubén D. Costa   +6 more
wiley   +1 more source

Predicting melting points of organic molecules : applications to aqueous solubility prediction using the General Solubility Equation [PDF]

, 2015
In this work we make predictions of several important molecular properties of academic and industrial importance to seek answers to two questions: 1) Can we apply efficient machine learning techniques, using inexpensive descriptors, to predict melting ...
McDonagh, James, Mitchell, John B. O., van Mourik, Tanja   +2 more
core   +1 more source

Mechanical and Solvent Transport Characteristics of Nitro and n-Butylphenyl Supported Poly(1,3,4-Oxadiazole)s [PDF]

, 2020
Examination of mechanical and solvent transport properties of π-conjugated polymers (PCPs), viz;poly(2-nitro-p-phenylene-1,3,4-oxadiazole) [PNPO], poly(p-phenylenevinylene-1,3,4-oxadiazole) [PPVO], poly(p-(nitrophenylene)vinylene-1,3,4-oxadiazole) [PNPVO]
Gopalakrishnanpanicker, Unnikrishnan, Kaippamangalath, Nimisha, Ramamurthy, Praveen C.   +2 more
core   +2 more sources

Activity Profiling of Nitro‐Substituted Di(Hetero)Aryl 1,3,4‐ and 1,2,4‐Oxadiazoles: Antimicrobial, Cholinesterase Inhibition and Antioxidant Potential

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
Novel nitro‐substituted diaryl 1,3,4‐ and 1,2,4‐oxadiazoles were synthesised via molecular hybridisation of bioactive heterocycles. Selected derivatives exhibited potent antimicrobial activity, including against Mycobacterium tuberculosis and Staphylococcus aureus, and cholinesterase inhibitory activity, with promising selectivity.
Enikő Šikorová, Šárka Štěpánková, Eva Frýbová, Klára Konečná, Jana Korbielová, Markéta Švarcová, Ondřej Janďourek, Václav Pflégr, Szilvia Bősze, Martin Krátký   +9 more
wiley   +1 more source