Results 51 to 60 of about 2,500 (166)

Electrochemical Dehydration Reaction

ChemSusChem, Volume 18, Issue 20, October 23, 2025.
Electrochemical dehydration reactions are a fascinating and underexplored field of research in the domain of electrosynthesis. They offer a sustainable alternative to hazardous and harsh dehydration reagents. In this review, the recent progress that has been made in this emerging research topic is surveyed.
Johannes Schneider, Enrico Lunghi, Siegfried R. Waldvogel   +2 more
wiley   +1 more source

Synthesis and evaluation of some new 1,3,4-oxadiazoles bearing thiophene, thiazole, coumarin, pyridine and pyridazine derivatives as antiviral agents

Acta Pharmaceutica, 2019
In an attempt to produce heterocyclic compounds based on 1,3,4-oxadiazole derivatives with potential antiviral activity, synthesis of compound 1 [2-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)acetonitrile] was performed through the reaction of cyanoacetic
Albratty Mohammed, El-Sharkawy Karam Ahmed, Alhazmi Hassan Ahmed   +2 more
doaj   +1 more source

The Role of Five‐Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview

ChemMedChem, Volume 20, Issue 16, August 16, 2025.
Several derivatives incorporating five‐membered aromatic rings are described in this review as bile acid receptor modulators, particularly targeting the farnesoid X receptor and the G protein‐coupled bile acid receptor 1. This review provides a comprehensive analysis of patents and literature that is useful to support researchers in the design of new ...
Claudia Finamore, Carmen Festa, Rosa Barbato, Stefano Fiorucci, Angela Zampella, Simona De Marino   +5 more
wiley   +1 more source

Synthesis, Characterization and Effect of bis-1,3,4Oxadiazole Containing Glycine Moiety on the Activity of Some Transferase Enzymes.

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
  We described herein the synthesis of novel bis-1,3,4-oxadiazole containing glycine moiety. N-{5-[5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-yl-sulfanyl]-1,3,4-oxadiazole-2-yl-methyl}-4methoxybenzamide was fully characterized by elemental analysis, FT-IR ...
I. H. R. Tomi, A. H. J. Al-Qaisi, Z. H. J. Al-Qaisi   +2 more
doaj  

Effect of 1,3,4-oxadiazoles on expression of biofilm-associated bap gene in clinical isolates of multidrug-resistant Acinetobacter baumannii

Scientific Reports
The rise of multidrug-resistant (MDR) pathogens, particularly Acinetobacter baumannii, poses a significant threat to global health due to its resistance to multiple antibiotics, biofilm-forming capacity, and associated poor clinical outcomes.
Ali Rahimbakhsh, Mahdi Seyfahmadi, Ali Souldozi, Rakhshan Hakimelahi, Mohammad Yousef Alikhani, Farshid Kafilzadeh   +5 more
doaj   +1 more source

Synthesis of a series of novel tetra-tert-butylcalix[4]arene linked to 1,2,4-triazole and 1,3,4-oxadiazole derivatives

Acta Chimica Slovenica, 2016
A series of tetra-tert-butylcalix[4]arene linked to 1,2,4-triazole-5-thiones and 1,3,4-oxadiazole-5-thiones derivatives at lower rim were synthesized by the reaction of 1,2,4-triazole-5-thione and 1,3,4-oxadiazole-5-thione  with 5,11,17,23-tetra-tert ...
Karim Akbari Dilmaghani, Zahra Dono Ghezelbash   +1 more
doaj   +1 more source

Advances in Mechanochemical Methods for One‐Pot Multistep Organic Synthesis

Chemistry – A European Journal, Volume 31, Issue 34, June 17, 2025.
This review highlights recent advances in mechanochemical methods for multistep organic synthesis, focusing on sequential one‐pot approaches performed by grinding or ball milling. The presented transformations are discussed in terms of efficiency, applicability, and sustainability, assessing both the challenges and potential of solvent‐free one‐pot ...
Nina Biedermann, Michael Schnürch
wiley   +1 more source

Inorganic base-catalyzed formation of antivirally active N-substituted benzamides from α-amido sulfones and N-nucleophile

Chemistry Central Journal, 2011
Background Heteronucleophiles as well as carbanionic reagents can be used to react with α-amido sulfones, thus giving the opportunity to prepare a large array of amino derivatives.
Wang Zhenchao, Bhadury Pinaki S, Li Xiangyang, Hu Deyu, Song Baoan, Jin Yi, Yang Song   +6 more
doaj   +1 more source

β‐Lactam Ylidenes: An Overlooked Class of N‐Heterocyclic Carbenes

Chemistry – A European Journal, Volume 31, Issue 31, June 3, 2025.
A highly modular synthetic approach toward four‐membered β‐lactam carbenes (BLCs) is presented. BLCs feature moderate σ‐donor and strong π‐acceptor character, leading to a pronounced ambiphilic reactivity which includes the formation of olefinic dimers as well as unprecedented N2‐bridged dimers, oxirane formation with acetone, and fragmentation to ...
Leonard Karl, Daniel Deißenbeck, Jan Meisner, Christian Ganter   +3 more
wiley   +1 more source

Systematic Review on 1,2,3‐Oxadiazoles, 1,2,4‐Oxadiazoles, and 1,2,5‐Oxadiazoles in the Antimycobacterial Drug Discovery

ChemMedChem, Volume 20, Issue 9, May 5, 2025.
The review focuses on relationships of oxadiazole derivative structures and their antimycobacterial activity including target structures in mycobacteria, in vitro or in vivo pharmacokinetic parameters, and toxicity. Apart from direct antimycobacterial activity, some 1,2,4‐oxadiazole derivatives can potentiate the antimycobacterial effect of ethionamide
Marta Kučerová‐Chlupáčová
wiley   +1 more source