Results 71 to 80 of about 15,523 (224)

Structure‐Guided Optimization and Biological Validation of 1,3,4‐Thiadiazole‐Based SIRT2 Inhibitors Reinforcing Channel Entrance Interactions

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT SIRT2, the cytoplasmic member of the sirtuin family, is generally acknowledged to promote cancer and contribute to the progression of various pathologies, including neurodegeneration, inflammation, obesity, and bacterial infection through the deacetylation of target substrates.
Ahmet Bugra Aksel, Fikriye Ozgencil, Filiz Bakar‐Ates, Habibe Beyza Gunindi, Alberto Massarotti, Erva Ozkan, Selen Gozde Kaya, Mahmut Gozelle, Yesim Ozkan, Gokcen Eren   +9 more
wiley   +1 more source

Syntheses, Evaluation and Characterization of Some 1, 3, 4-Oxadiazoles as Antimicrobial Agents

E-Journal of Chemistry, 2009
1,3,4-Oxadiazoles show various biological activities and have been synthesized from different compounds. 1,3,4-oxadiazole is popularly known for its antimicrobial, anti-inflammatory, pesticidal and antihypertensive activities etc.
Niti Bhardwaj, S. K. Saraf, Pankaj Sharma, Pradeep Kumar   +3 more
doaj   +1 more source

Synthesis, Characterization of some New 1, 3, 4-Oxadiazole derivatives based on 4- amino benzoic acid

مجلة بغداد للعلوم, 2016
In this research various of 2,5-disubstituted 1,3,4-oxadiazole (Schiff base, oxo-thiazolidine , and other compounds) were synthesized from 2,5-di(4,4?- amino-1,3,4-oxadiazole ) which use quently synthesized from mixture of 4-amino benzoic acid and ...
Baghdad Science Journal
doaj   +1 more source

Síntese de duas novas séries de compostos com estrutura discótica contendo derivados do ácido gálico [PDF]

, 2008
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemática. Programa de Pós-Graduação em QuímicaNesta dissertação, são descritas a síntese e as propriedades térmicas de duas séries de compostos com estrutura ...
Frizon, Tiago Elias Allievi
core  

Novel 1,3,4-Oxadiazole-2-carbohydrazides as Prospective Agricultural Antifungal Agents Potentially Targeting Succinate Dehydrogenase

, 2019
A novel simple 1,3,4-oxadiazole-2-carbohydrazide was reported to discover low-cost and versatile antifungal agents. Bioassay results suggested that a majority of the designed compounds were extremely bioactive against four types of fungi and two kinds of
Jian-Jun Zhu, Li-Wei Liu, Pei-Yi Wang, Yuan-Yuan Wu, Song Yang, Wu-Bin Shao, Yuan-Yuan Wu (5269484), Pei-Yi Wang (306058), Zhou-Qing Long (8103521), Song Yang (162335), Zhou-Qing Long, Jian-Jun Zhu (2245093), Zhong Li, Wu-Bin Shao (4507489), Zhong Li (324520), Li-Wei Liu (1415464)   +15 more
core   +1 more source

Synthesis, Characterization, and Biological Evaluation of Aliphatic‐Substituted Benzimidazole Derivatives: Induction of Apoptosis, Cell Cycle Arrest, and Molecular Docking in Breast Cancer Cells

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT A new series of aliphatic‐substituted benzimidazole derivatives was synthesized and structurally characterized to evaluate their potential anticancer activity. Among the synthesized compounds, compound 4 exhibited the most potent cytotoxic effects against MCF‐7 and MDA‐MB‐231 breast cancer cell lines, with IC₅₀ values comparable to those of ...
Murat Keser, Çisil Çamlı Pulat, Harika Atmaca, Hakan Akgün, Canan Albay, Emre Menteşe, Hakan Bektaş, Suleyman Ilhan   +7 more
wiley   +1 more source

In Silico, In Vitro, and In Vivo Antinociceptive Potential of S‐Naproxen Derivatives

ChemistryOpen, Volume 15, Issue 4, April 2026.
Selected naproxen derivatives were investigated for their antinociceptive effects, using in vitro (COX‐I/COX‐II antagonistic effect), in vivo (acetic acid and hot plate assay), and in silico (molecular simulation studies) approaches. The COX inhibition studies revealed that the maximum percent effect exhibited by GMO‐I‐111a 96.01 and 92% against COX‐2 ...
Ubaidullah, Naveed Muhammad, Abad Khan, Rahaf Ajaj, Abdur Rauf, Umer Rashid, Fahad Hussain, Rashid Khan, Faiza Seraj, Uzma Uzma, Basharat Ali, Abdul Sadiq, Khalid Mohammed Khan, Marcello Iriti   +13 more
wiley   +1 more source

Radical Retrosynthesis of Natural Products Enabled by Iron‐Based Reductive Olefin Coupling

Angewandte Chemie Novit, Volume 2, Issue 1, March 2026.
This review highlights iron‐catalyzed reductive olefin coupling (ROC)—a strategy for C─C bond formation driven by metal‐hydride hydrogen atom transfer (MHAT)—as a key tool in natural products synthesis. This review surveys dozens of total syntheses employing ROC‐based strategies, highlighting its power to forge strained rings, quaternary centers, and ...
Griffin L. Barnes, Alex L. Rerick, Phil S. Baran   +2 more
wiley   +1 more source

Synthesis, Spectral Characterization and Biocidal Studies of Copper(II) Complexes of Chromen-2-one-3-carboxy Hydrazide and 2-(Chromen-3'-onyl)-5-(aryl)-1,3,4-oxadiazole Derivatives

E-Journal of Chemistry, 2011
Copper(II) complexes of chromen-2-one-3-carboxyhydrazide and 2-(chromen-3'-onyl)-5-(aryl)-1,3,4-oxadiazole derivatives have been synthesized. The structural features have been determined from their microanalytical, magnetic susceptibility, molar ...
Glory Mathew, R. Krishnan, Molly Antony, M. S. Suseelan   +3 more
doaj   +1 more source

From Synthesis to Synergy: Pyrazole and 1,3,4-Oxadiazole Scaffolds as Versatile Platforms for Multitarget Anticancer Drug Design [PDF]

Journal of Advanced Biomedical and Pharmaceutical Sciences
Pyrazole and 1,3,4-oxadiazole are two key scaffolds in medicinal chemistry. The incorporation of both pharmacophores into a single hybrid molecule has attracted considerable attention because of the potential for synergistic enhancement of biological ...
Arwa Aboukar, Aliaa Mohassab, Heba Hassan, Mamdouh Mohamed   +3 more
doaj   +1 more source