Results 91 to 100 of about 18,084 (219)

Synthesis of a series of novel tetra-tert-butylcalix[4]arene linked to 1,2,4-triazole and 1,3,4-oxadiazole derivatives

Acta Chimica Slovenica, 2016
A series of tetra-tert-butylcalix[4]arene linked to 1,2,4-triazole-5-thiones and 1,3,4-oxadiazole-5-thiones derivatives at lower rim were synthesized by the reaction of 1,2,4-triazole-5-thione and 1,3,4-oxadiazole-5-thione  with 5,11,17,23-tetra-tert ...
Karim Akbari Dilmaghani, Zahra Dono Ghezelbash   +1 more
doaj   +1 more source

Structure-activity relationship of 1,3,4- oxadiazole compounds [PDF]

, 2017
Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica MoldovaIntroducere. Derivaţii de oxadiazol se prezintă ca substanţe cu activitate terapeutică vastă: antimicrobială, antiparazitară, antiinflamatoare, anticanceroasă ...
Podgornîi, Ana, Motroi, Luminiţa
core   +1 more source

Design, Synthesis, Crystal Structure and Anticancer Evaluation of Novel Chiral 1,3,4-Oxadiazole Derivatives Mimicking Paclitaxel Pharmacophore

Journal of Chemistry
1,3,4-Oxadiazole heterocycles exhibit versatile pharmacological activities and have emerged as privileged scaffolds for developing antiviral and anticancer drug candidates in pharmaceutical chemistry.
Li Wang, Jingxuan Liu, Qian Li
doaj   +1 more source

Synthesis and Antibacterial Activity of New Hybrid Molecules Containing 1,3,4-Thiadiazole and 1,3,4-Oxadiazole Bearing Ibuprofen Moiety

Ibn Al-Haitham Journal for Pure and Applied Sciences
A series of novel hybrid molecules containing 1,3,4-oxadiazole and 1,3,4-thiadiazole moieties bearing an ibuprofen moiety were designed, synthesized, and evaluated for their in vitro antibacterial activity against Gram-positive and Gram-negative ...
Rusul K. Fadhel Fadhel , Jumbad H. Tomma   +1 more
doaj   +1 more source

Anti-Inflammatory, Analgesic Evaluation and Molecular Docking Studies of N-Phenyl Anthranilic Acid-Based 1,3,4-Oxadiazole Analogues

Journal of Chemistry, 2013
A novel series of N-phenyl anthranilic acid-based 1,3,4-oxadiazoles were prepared (4a–h) and subjected to anti-inflammatory, analgesic activity and molecular docking studies to target cyclooxygenase-2 enzyme.
Suman Bala, Sunil Kamboj, Vipin Saini, D. N. Prasad   +3 more
doaj   +1 more source

Tổng hợp dẫn xuất mang khung kết hợp 1,3,4-oxadiazole/benzimidazole

Tạp chí Khoa học Đại học Cần Thơ, 2019
Các hợp chất dị vòng chứa khung 1,3,4-oxadiazole hay benzimidazole được biết có nhiều hoạt tính sinh học đáng quý như kháng khuẩn, kháng nấm, giảm đau, kháng viêm, kháng virus, kháng ung thư, hạ huyết áp, kháng đái tháo đường và kháng oxy hóa.
Nguyễn Thị Kim Huyền, Bùi Thị Bửu Huê, Hieu Mai Van, Danh La Đức Thành   +3 more
doaj   +1 more source

1,3,4-Oxadiazole as an Anticancer Agent

International Journal For Multidisciplinary Research
The modern era's fastest-growing disease is cancer, it poses a serious threat to people's lives. For the treatment of various cancers, the FDA has approved a number of medications. However, because of the rise in drug toxicity incidents, there is a continual need for the discovery of novel anti-cancer drugs.
Vaishnavi Chopade -, Vinayak Gaware -
openaire   +1 more source

Síntese de novos mesógenos derivados do heterocíclo imidazo[2,1-b][1,3,4]tiadiazol [PDF]

, 2009
TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Curso de Química.A síntese de seis novas moléculas derivadas do heterociclo imidazo[2,1-b][1,3,4]tiadiazol foram realizadas a partir da construções de ...
Ferraz Neto, José
core  

Regioselective Synthesis of 2‑Amino-Substituted 1,3,4-Oxadiazole and 1,3,4-Thiadiazole Derivatives via Reagent-Based Cyclization of Thiosemicarbazide Intermediate

, 2016
A regioselective, reagent-based method for the cyclization reaction of 2-amino-1,3,4-oxadiazole and 2-amino-1,3,4-thiadiazole core skeletons is described. The thiosemicarbazide intermediate 3 was reacted with EDC·HCl in DMSO or p-TsCl, triethylamine in N-
Seung-Ju Yang (1463140), Young-Dae Gong (1463149), Hyun-Jung Kwak (2001277), Seok-Hyeong Lee (2001280)   +3 more
core   +1 more source

A Combined Synthetic and DFT Study on the Catalyst-Free and Solvent-Assisted Synthesis of 1,3,4-Oxadiazole-2-thiol Derivatives

Journal of Chemistry, 2013
A novel practical and efficient catalyst-free method for the synthesis of 5-substituted 1,3,4-oxadiazole-2-thiols has been developed, which is assisted by reaction solvent (DMF).
Mohammad Soleiman-Beigi, Reza Aryan, Maryam Yousofizadeh, Shima Khosravi   +3 more
doaj   +1 more source