Results 101 to 110 of about 15,523 (224)

Pharmaceutical approaches of 1,3,4-oxadiazole derivatives [PDF]

, 2016
Chair of pharmaceutical and toxicological chemistry, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, The 6th International Medical Congress for Students and Young Doctors, May 12-14, 2016Introduction: 1,3,4 ...
Motroi, Luminita, Podgornii, Ana
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Tổng hợp dẫn xuất mang khung kết hợp 1,3,4-oxadiazole/benzimidazole

Tạp chí Khoa học Đại học Cần Thơ, 2019
Các hợp chất dị vòng chứa khung 1,3,4-oxadiazole hay benzimidazole được biết có nhiều hoạt tính sinh học đáng quý như kháng khuẩn, kháng nấm, giảm đau, kháng viêm, kháng virus, kháng ung thư, hạ huyết áp, kháng đái tháo đường và kháng oxy hóa.
Nguyễn Thị Kim Huyền, Bùi Thị Bửu Huê, Hieu Mai Van, Danh La Đức Thành   +3 more
doaj   +3 more sources

Cathepsin K inhibitors based on 2-amino-1,3,4-oxadiazole derivatives

, 2021
Two new series of hitherto unknown dipeptides, containing an electrophilic nitrile or a non-electrophilic 2-amino-1,3,4-oxadiazole moiety were synthesized and evaluated in vitro as Cathepsin K (Cat K) inhibitors.
Érika Lorena Fonseca Costa de Alvarenga, Rossimiriam Pereira de Freitas, Patrícia da Silva Lima, Marcelo Yudi Icimoto, Raquel Leão Neves, Alexandre Alves de Castro, Teodorico de Castro Ramalho, Talita Bárbara Gontijo, Adriana Karaoglanovic Carmona, Eufrânio Nunes da Silva Júnior   +9 more
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Inorganic base-catalyzed formation of antivirally active N-substituted benzamides from α-amido sulfones and N-nucleophile

Chemistry Central Journal, 2011
Background Heteronucleophiles as well as carbanionic reagents can be used to react with α-amido sulfones, thus giving the opportunity to prepare a large array of amino derivatives.
Wang Zhenchao, Bhadury Pinaki S, Li Xiangyang, Hu Deyu, Song Baoan, Jin Yi, Yang Song   +6 more
doaj   +1 more source

Regioselective Synthesis of 2‑Amino-Substituted 1,3,4-Oxadiazole and 1,3,4-Thiadiazole Derivatives via Reagent-Based Cyclization of Thiosemicarbazide Intermediate

, 2016
A regioselective, reagent-based method for the cyclization reaction of 2-amino-1,3,4-oxadiazole and 2-amino-1,3,4-thiadiazole core skeletons is described. The thiosemicarbazide intermediate 3 was reacted with EDC·HCl in DMSO or p-TsCl, triethylamine in N-
Seung-Ju Yang (1463140), Young-Dae Gong (1463149), Hyun-Jung Kwak (2001277), Seok-Hyeong Lee (2001280)   +3 more
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Anti-Inflammatory, Analgesic Evaluation and Molecular Docking Studies of N-Phenyl Anthranilic Acid-Based 1,3,4-Oxadiazole Analogues

Journal of Chemistry, 2013
A novel series of N-phenyl anthranilic acid-based 1,3,4-oxadiazoles were prepared (4a–h) and subjected to anti-inflammatory, analgesic activity and molecular docking studies to target cyclooxygenase-2 enzyme.
Suman Bala, Sunil Kamboj, Vipin Saini, D. N. Prasad   +3 more
doaj   +1 more source

Biological activity of heterocyclic systems based on functionally substituted 1,3,4-thia(oxa)diazoles (a review)

Фармацевтичний журнал, 2019
1,3,4-Thiadiazole and oxadiazole hetetocycles are well-known pharmacophore scaffolds, which possess wide possibility for chemical modification and identified diverse pharmacological potential.
M. I. Lelyukh
doaj   +1 more source

Synthesis, Characterization, and Cytotoxicity Assessment of Novel S- Naproxen- based 1,3,4-Oxadiazole Thioethers against A549 Lung Carcinoma

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Novel S-naproxen- 1,3,4-oxadiazole derivatives were developed and synthesized. via a multi-step route. The synthesis began with conversion of S-(+)-naproxen to an ethyl ester, followed by hydrazide formation and cyclization to yield a 1,3,4-oxadiazole-2-
Farooq Mohammed Hassan, Ayad Kareem Khan, Shakir Mahmood Alwan, Mohammad M. Al-Akaidi   +3 more
doaj   +1 more source

A Combined Synthetic and DFT Study on the Catalyst-Free and Solvent-Assisted Synthesis of 1,3,4-Oxadiazole-2-thiol Derivatives

Journal of Chemistry, 2013
A novel practical and efficient catalyst-free method for the synthesis of 5-substituted 1,3,4-oxadiazole-2-thiols has been developed, which is assisted by reaction solvent (DMF).
Mohammad Soleiman-Beigi, Reza Aryan, Maryam Yousofizadeh, Shima Khosravi   +3 more
doaj   +1 more source

Metalomesogenos : sintese e comportamento [PDF]

, 1996
Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas.A síntese e caracterização (por microscopia ótica, espectroscopias de infra-vermelho e ressonância magnética nuclear, e análise elementar) de ...
Meyer, Emerson
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