Results 61 to 70 of about 2,500 (166)

Synthesis of Some New Heterocyclic Fused Rings Compounds Based on 5-Aryl-1,3,4-Oxadiazole

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
The work includes synthesis and characterization of some new heterocyclic compounds, as flow: The compound (3) (5-(4-chlorophenyl) -2-hydrazinyl-1,3,4-oxadiazole was synthesized by using two methods; the first method includes the direct reaction between
Zahra Mohammed Abbas, Dhuha Faruq Hussain, Raied Mustafa Shakir   +2 more
doaj  

Anti-Inflammatory, Analgesic Evaluation and Molecular Docking Studies of N-Phenyl Anthranilic Acid-Based 1,3,4-Oxadiazole Analogues

Journal of Chemistry, 2013
A novel series of N-phenyl anthranilic acid-based 1,3,4-oxadiazoles were prepared (4a–h) and subjected to anti-inflammatory, analgesic activity and molecular docking studies to target cyclooxygenase-2 enzyme.
Suman Bala, Sunil Kamboj, Vipin Saini, D. N. Prasad   +3 more
doaj   +1 more source

Tổng hợp dẫn xuất mang khung kết hợp 1,3,4-oxadiazole/benzimidazole

Tạp chí Khoa học Đại học Cần Thơ, 2019
Các hợp chất dị vòng chứa khung 1,3,4-oxadiazole hay benzimidazole được biết có nhiều hoạt tính sinh học đáng quý như kháng khuẩn, kháng nấm, giảm đau, kháng viêm, kháng virus, kháng ung thư, hạ huyết áp, kháng đái tháo đường và kháng oxy hóa.
Nguyễn Thị Kim Huyền, Bùi Thị Bửu Huê, Hieu Mai Van, Danh La Đức Thành   +3 more
doaj   +1 more source

Biological activity of heterocyclic systems based on functionally substituted 1,3,4-thia(oxa)diazoles (a review)

Фармацевтичний журнал, 2019
1,3,4-Thiadiazole and oxadiazole hetetocycles are well-known pharmacophore scaffolds, which possess wide possibility for chemical modification and identified diverse pharmacological potential.
M. I. Lelyukh
doaj   +1 more source

Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole

Molecules, 2018
Compounds containing 1,3,4-oxadiazole ring in their structure are characterised by multidirectional biological activity. Their anti-proliferative effects associated with various mechanisms, such as inhibition of growth factors, enzymes, kinases and ...
Teresa Glomb, Karolina Szymankiewicz, Piotr Świątek   +2 more
doaj   +1 more source

A Combined Synthetic and DFT Study on the Catalyst-Free and Solvent-Assisted Synthesis of 1,3,4-Oxadiazole-2-thiol Derivatives

Journal of Chemistry, 2013
A novel practical and efficient catalyst-free method for the synthesis of 5-substituted 1,3,4-oxadiazole-2-thiols has been developed, which is assisted by reaction solvent (DMF).
Mohammad Soleiman-Beigi, Reza Aryan, Maryam Yousofizadeh, Shima Khosravi   +3 more
doaj   +1 more source

Synthesis, Characterization and study biologicalactivity of several 1-cyclopentene-1,2-dicarboxylimidyl Containing oxadiazole and Benzothiazole

مجلة بغداد للعلوم, 2014
In this work involved prepared of several new 1-cyclopentene-1,2-dicarboxylimide linked to oxadiazole and benzothiazole moiety were synthesized by two steps: The first step 2-amino-substituted-1,3,4-oxadiazoles and substituted-2-aminobenzothiazole were ...
Baghdad Science Journal
doaj   +1 more source

Crystal structure of 3-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-5-(thiophen-2-yl)-1,3,4-oxadiazole-2(3H)-thione

Acta Crystallographica Section E: Crystallographic Communications, 2016
The title compound, C18H20N4O2S2, is a new 1,3,4-oxadiazole and a key pharmacophore of several biologically active agents. It is composed of a methyl(thiophen-2-yl)-1,3,4-oxadiazole-2(3H)-thione moiety linked to a 2-methoxyphenyl unit via a piperazine ...
Monirah A. Al-Alshaikh, Hatem A. Abuelizz, Ali A. El-Emam, Mohammed S. M. Abdelbaky, Santiago Garcia-Granda   +4 more
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Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents

Molecules, 2015
In the present study, a new series of 2,5-disubstituted-1,3,4-thiadiazole tethered 1,2,4-triazole, 1,3,4-thiadiazole, 1,3,4-oxadiazole and Schiff base derivatives were synthesized and characterized by IR, 1H-NMR, 13C-NMR, MS and elemental analyses.
Nadjet Rezki, Amjad M. Al-Yahyawi, Sanaa K. Bardaweel, Fawzia F. Al-Blewi, Mohamed R. Aouad   +4 more
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Synthesis, Characterization, and Cytotoxicity Assessment of Novel S- Naproxen- based 1,3,4-Oxadiazole Thioethers against A549 Lung Carcinoma

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Novel S-naproxen- 1,3,4-oxadiazole derivatives were developed and synthesized. via a multi-step route. The synthesis began with conversion of S-(+)-naproxen to an ethyl ester, followed by hydrazide formation and cyclization to yield a 1,3,4-oxadiazole-2-
Farooq Mohammed Hassan, Ayad Kareem Khan, Shakir Mahmood Alwan, Mohammad M. Al-Akaidi   +3 more
doaj   +1 more source