Results 31 to 40 of about 12,947 (217)
Pharmaceuticals, 2022 2,5-Disubstituted 1,3,4-oxadiazoles are privileged versatile scaffolds in medicinal chemistry that have exhibited diverse biological activities. Acetyl- (AChE) and butyrylcholinesterase (BChE) inhibitors are used, e.g., to treat dementias and myasthenia ...
Václav Pflégr +5 more
doaj +1 more source
Synthesis of Some Substituted 1,3,4-Oxadiazoles from Hydrazones [PDF]
مجلة التربية والعلم, 2009 In this paper the synthesis of some 2-(3-pyridyl)-5-aryl-1,3,4-oxadiazoles from hydrazones is reported. Nicotinic acid was converted to ethyl nicotinate (1) by its reaction with thionyl chloride and the resultant acid chloride was treated with absolute ...
Khalid Daoud, A. Ahmad, Amal Ali
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Synthesis a Number of Heterocyclic Compounds and some of chalcones Derived From Levofloxacin
Tikrit Journal of Pure Science, 2023 The hydrazide (1) was used as synthone for the following Compound pyridazine-3,6-dione (2) by reaction of hydrazide (1) with maleic anhydride and Compound phthalazine-1,4-dione (3) by the reaction of hydrazide (1) with phthalic anhydride.
Ekram Abdullah Basheer +2 more
doaj +1 more source
2-(4-Bromophenoxy)propanohydrazide
Acta Crystallographica Section E, 2009 The title compound, C9H11BrN2O2, is an important intermediate for the synthesis of heterocyclic compounds such as azoles, 2,5-disubstituted-1,3,4-oxadiazoles and 5-substituted 2-mercapto-1,3,4-oxadiazoles. The bromophenoxy group subtends a dihedral angle
Shahid Hameed +3 more
doaj +1 more source
Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole [PDF]
Molecules, 2018 Compounds containing 1,3,4-oxadiazole ring in their structure are characterised by multidirectional biological activity. Their anti-proliferative effects associated with various mechanisms, such as inhibition of growth factors, enzymes, kinases and others, deserve attention.
Teresa Glomb +2 more
openaire +3 more sources
Chemical and Pharmaceutical Bulletin, 2013 A new class of mono and bis heterocycles-styrylsulfonylmethyl 1,3,4-oxadiazoles, pyrazolyl/isoxazolyl-1,3,4-oxadiazoles were prepared and studied their antioxidant activity. The compound methyl substituted 2-(p-methylphenylamino-sulfonylmethyl)-5-[Z-(p-methylstyrylsulfonylmethyl)]-1,3,4-oxadiazole displayed slightly higher antioxidant activity than the
Mallikarjuna Reddy, Guda +5 more
openaire +3 more sources
Synthesis of 1,3,4-Oxadiazole Derivatives from Ethyl-2-Piperidone-3-Carboxylate [PDF]
مجلة التربية والعلم, 2012 In the present work, some new 1,3,4- Oxadiazole derivatives have been synthesized from Ethyl-2-Piperidone-3-Carboxylate. The reaction of the ethyl ester with hydrazine hydrate afforded the corresponding hydrazide (I).
M. A. Sheat, O. I. Mohammed
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Diazo Transfer From Nitrous Oxide Employing Phosphorus Ylides
Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.A phosphorus ylide‐mediated strategy achieves the direct fixation of nitrous oxide (N2O) to access diazo compounds, which after intra‐ or intermolecular trapping, afford N2‐containing organic building blocks. This approach provides an alternative to hazardous diazo‐transfer reagents and establishes N2O fixation as a sustainable methodology.
Jhen‐Kuei Yu +4 more
wiley +2 more sources
, 2022 A new library of bis-thiazol-1,2,4-triazinehybrids having 1,3,4-oxadiazoles (10a–j) has been designed and synthesized. They were examined for their preliminary anticancer properties against four selected human cancer cell lines including SiHa (cervix ...
Suresh Bairi (14007462) +2 more
core +1 more source
SYNTHESIS OF MONO-SUBSTITUTED AND SIMMETRICALLY 2, 5-DISUBSTITUTED 1, 3, 4-OXADIAZOLES [PDF]
Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2012 In recent years 1,3,4-oxadiazoles have received considerable attention due to their wide range of biological activities and practical importance. They form an important class of fi ve-member heterocyclic compounds with a variety of derivatives.
Z. Ribcovskaia, F. Macaev
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