Results 41 to 50 of about 1,474 (179)

Synthesis and Antimicrobial Evaluation of Some New Oxadiazoles Derived from Phenylpropionohydrazides

Molecules, 2009
In this study a series ofnew1-(2-aryl-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanones 2a-e was synthesized by the cyclization of imines 1a-e using acetic anhydride. The products were evaluated for anti-bacterial and anti-fungal activity.
Mohammad Ali, Mohammad Shaharyar, Neeraj Kumar Fuloria, Vijender Singh   +3 more
doaj   +1 more source

Regioselective Oxidative Oligomerization of 2‐Tert‐Butylpyrene Toward Structurally Defined Oligomers and Their Application in Organic Light‐Emitting Diodes

European Journal of Organic Chemistry, Volume 29, Issue 36, 24 September 2026.
Treatment of 2‐tert‐butylpyrene with Cu2+ afforded structurally well‐defined pyrene oligomers, up to the 13‐mer. Single‐crystal X‐ray diffraction, spectroscopic analyses, and computational studies were conducted to evaluate the properties of the resulting oligopyrenes.
Md Jadu Mia, Daiki Tauchi, Miku Mizoe, Teru Hashimoto, Masashi Hasegawa, Hiroaki Chihara, Hiroto Iwano, Shigeyuki Yagi, Marco Fusè, Giuseppe Mazzeo, Giovanna Longhi, Sergio Abbate, Qingyu Wang, Tamaki Nakano, Ken‐ichi Sugiura   +14 more
wiley   +1 more source

Heterocyclic‐Based Fungicides: Emerging Strategies for Viable Plant Disease Control

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Heterocyclic compounds have attracted considerable attention because of their structural diversity, potent antifungal activity, and ability to interact with multiple fungal targets, offering broad‐spectrum protection against phytopathogens. Synthetic and semisynthetic/part‐natural scaffolds, particularly azole, quinoline, indole, cyclotryptamine, and ...
Sumit Tahlan, Meenakshi Kaira, Sucheta Singh, Hrithik Dey, Kailash C. Pandey   +4 more
wiley   +1 more source

PHOTOLYSIS OF 1,3,4-OXADIAZOLES IN ALCOHOLS [PDF]

Chemistry Letters, 1977
Abstract Irradiation of 2,5-diphenyl-1,3,4-oxadiazole in alcohols induces a heterolytic addition of alcohols to the C=N bond of the oxadiazole, followed by cycloelimination to yield benzoic acid ester and benzonitrile imine. The latter reacts with the oxadiazole to form 4-benzamido-3,5-diphenyl-1,2,4-triazole which is photochemically ...
Otohiko Tsuge, Koji Oe, Masashi Tashiro
openaire   +1 more source

Diazo Transfer From Nitrous Oxide Employing Phosphorus Ylides

Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.
A phosphorus ylide‐mediated strategy achieves the direct fixation of nitrous oxide (N2O) to access diazo compounds, which after intra‐ or intermolecular trapping, afford N2‐containing organic building blocks. This approach provides an alternative to hazardous diazo‐transfer reagents and establishes N2O fixation as a sustainable methodology.
Jhen‐Kuei Yu, Jan Niclas Ludwig, Patrick Wolf Antoni, David Tymann, Max Martin Hansmann   +4 more
wiley   +2 more sources

Deciphering the Medicinal Chemistry Aspects of Akt Inhibitors for the Management of Cancer: Structure–Activity Relationship Frameworks, Landscapes, and Optimization Approaches

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This review majorly describes the systematic development of Akt inhibitors involving numerous heterocyclic scaffolds along with their structure activity relationships to explore anticancer therapeutic strategies. ABSTRACT The Akt pathway is dysregulated in cancer, leading to proliferation, decreased apoptosis, and metastasis, and hence is a major ...
Mayur S. Dhangar, Mahesh B. Palkar
wiley   +1 more source

1,3,4-Oxadiazole derivatives as potential anti-glioma agents: synthesis, characterization, in vitro cytotoxic activity against HS683 cells, and molecular docking [PDF]

Pharmacia
The 1,3,4-oxadiazoles were synthesized by acid-catalyzed condensation of the hydrazides with aromatic aldehydes to give the hydrazones, which were then oxidized to the corresponding 1,3,4-oxadiazoles using I2/K2CO3 in DMSO.
Rabab Jameel Hashim, Hiba Najeh Alsaad, Husam Hamza Salman   +2 more
doaj   +3 more sources

Sulfonamide‐Based 2‐Amino‐1,3,4‐Oxadiazole Derivatives as Dual Cholinesterase and Carbonic Anhydrase Inhibitors: Design, Synthesis, Kinetic Characterization, Molecular Modeling, and ADMET Evaluation

Drug Development Research, Volume 87, Issue 6, September 2026.
ABSTRACT In this study, 12 novel sulfonamide derivatives incorporating 2‐amino‐1,3,4‐oxadiazole and 1,3‐benzazol‐2(3H)‐one scaffolds were synthesized and structurally characterized using 1H NMR, 13C NMR, and LC–MS analyses. Their inhibitory activities were evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase I
Gülnur Arslan Karahan, Başak Gökçe, Muhammed Tilahun Muhammed, Emre Kadir Ayan, Azime Berna Özçelik   +4 more
wiley   +1 more source

Structural Modifications of Nonsteroidal Anti‐Inflammatory Drugs (NSAIDs): New Horizons in Antimicrobial Drug Discovery

Archiv der Pharmazie, Volume 359, Issue 8, August 2026.
This review provides a comprehensive analysis of the molecular modifications applied to NSAIDs to develop novel antimicrobial agents. By focusing on structural changes and their impact on biological activity, the study highlights innovative strategies to combat the global challenge of antimicrobial resistance.
Ebru Koçak Aslan, Ayşe Karagüzel, Miyase Gözde Gündüz   +2 more
wiley   +1 more source

Synthesis and Antimicrobial Activity of New 5-(2-Thienyl)-1,2,4-triazoles and 5-(2-Thienyl)-1,3,4-oxadiazoles and Related Derivatives

Molecules, 2010
New 5-(2-thienyl)-1,2,4-triazoles and 5-(2-thienyl)-1,3,4-oxadiazoles namely, N-[3-mercapto-5-(2-thienyl)-1,2,4-triazol-4-yl]-N'-arylthioureas 4a–e, 2-arylamino-5-(2-thienyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles 5a–e, 3-arylaminomethyl-5-(2-thienyl ...
Mohamed A. Al-Omar
doaj   +1 more source