Results 61 to 70 of about 37,093 (255)

Tyrosinase Inhibitory Activity, 3D QSAR, and Molecular Docking Study of 2,5-Disubstituted-1,3,4-Oxadiazoles

Journal of Chemistry, 2013
In continuation with our research program, in search of potent enzyme tyrosinase inhibitor, a series of synthesized 2,5-disubstituted 1,3,4-oxadiazoles have been evaluated for enzyme tyrosinase inhibitory activity.
Ramesh L. Sawant, Prashant D. Lanke, Jyoti B. Wadekar   +2 more
doaj   +1 more source

Synthesis and cytotoxic activity evaluation of novel dihydroartemisinin and zerumbone conjugates with 2-mercapto-1,3,4-oxadiazoles as potential EGFR inhibitors

Journal of Chemical Research, 2023
Sixteen conjugates of dihydroartemisinin and zerumbone with 2-mercapto-1,3,4-oxadiazoles were synthesized and structurally elucidated by 1D NMR, 2D NMR, and HRMS spectra.
Duc Quan Tran, Ngoc Hung Truong, Thi Hoang Anh Nguyen, Thi Thuy Trinh, Thi Cham Ba, Thi Thuy Linh Nguyen, Xuan Ha Nguyen, Manh Cuong Nguyen, Van Chinh Luu   +8 more
doaj   +1 more source

Dichloromethylation of enones by carbon nitride photocatalysis

, 2020
Small organic radicals are ubiquitous intermediates in photocatalysis and are used in organic synthesis to install functional groups and to tune electronic properties and pharmacokinetic parameters of the final molecule.
Antonietti, M., Kurpil, B., Mazzanti, S., Pieber, B., Savateev, A.   +4 more
core   +1 more source

Fluorescence-based proteasome activity profiling [PDF]

, 2012
With the proteasome emerging as a therapeutic target for cancer treatment, accurate tools for monitoring proteasome (inhibitor) activity are in demand.
Berkers, C.R., Jong, A., Ovaa, H., Rodenko, B., Schuurman, K.G.   +4 more
core   +1 more source

PHOTOLYSIS OF 1,3,4-OXADIAZOLES IN ALCOHOLS [PDF]

Chemistry Letters, 1977
Abstract Irradiation of 2,5-diphenyl-1,3,4-oxadiazole in alcohols induces a heterolytic addition of alcohols to the C=N bond of the oxadiazole, followed by cycloelimination to yield benzoic acid ester and benzonitrile imine. The latter reacts with the oxadiazole to form 4-benzamido-3,5-diphenyl-1,2,4-triazole which is photochemically ...
Otohiko Tsuge, Koji Oe, Masashi Tashiro
openaire   +1 more source

Photooxidation of N-acylhydrazones to 1,3,4-oxadiazoles catalyzed by heterogeneous visible-light-active carbon nitride semiconductor

Applied Catalysis B: Environmental, 2018
The remarkable bioactivity of 1,3,4-oxadiazoles permanently motivates chemists to develop new milder and broader approaches to synthesize new derivatives, as well as to improve the preparation methodologies of the known compounds.
Bogdan Kurpil, Katharina Otte, M. Antonietti, Aleksandr Savateev   +3 more
semanticscholar   +1 more source

Synthesis and Antimicrobial Evaluation of Some New Oxadiazoles Derived from Phenylpropionohydrazides

Molecules, 2009
In this study a series ofnew1-(2-aryl-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanones 2a-e was synthesized by the cyclization of imines 1a-e using acetic anhydride. The products were evaluated for anti-bacterial and anti-fungal activity.
Mohammad Ali, Mohammad Shaharyar, Neeraj Kumar Fuloria, Vijender Singh   +3 more
doaj   +1 more source

Poly(1,3,4-oxadiazoles) via aromatic nucleophilic displacement [PDF]

, 1992
Poly(1,3,4-oxadiazoles) (POX) are prepared by the aromatic nucleophilic displacement reaction of di(hydroxyphenyl) 1,3,4-oxadiazole monomers with activated aromatic dihalides or activated aromatic dinitro compounds. The polymerizations are carried out in
Connell, John W., Hergenrother, Paul M., Wolf, Peter   +2 more
core   +1 more source

Efficient one-pot, four-component synthesis of N,N-dibenzyl-N-{1-[5-(3-aryl)-1,3,4-oxadiazol-2-yl]cyclobutyl}amine derivatives from the reaction of (isocyanoimino)triphenylphosphorane, dibenzylamine, an aromatic carboxylic acid and cyclobutanone [PDF]

, 2012
Four-component reaction of cyclobutanone, dibenzylamine and (Nisocyanimino) triphenylphosphorane in the presence of aromatic carboxylic acids proceed smoothly at room temperature and under neutral conditions to afford N,N-dibenzyl-N-{1-[5-(3-aryl)-1,3,
Kazemizadeh Reza Ali, Ramazani Ali, Shajari Nahid   +2 more
core   +1 more source

Synthesis of cytotoxic urs-12-ene- and 28-nor-urs-12-ene- type conjugates with amino- and mercapto-1,3,4-oxadiazoles and mercapto-1,2,4-triazoles.

Steroids, 2020
A small library of 2-mercapto-1,3,4-oxadiazoles, 2-amino-1,3,4-oxadiazoles and 3-mercapto-1,2,4-triazoles attached to the urs-12-ene- and 28-nor-urs-12-ene skeleton has been obtained.
S. Popov, M. D. Semenova, D. Baev, T. Frolova, E. Shults, Chengzhang Wang, M. Turks   +6 more
semanticscholar   +1 more source