Results 61 to 70 of about 1,413 (178)

In Silico, In Vitro, and In Vivo Antinociceptive Potential of S‐Naproxen Derivatives

ChemistryOpen, Volume 15, Issue 4, April 2026.
Selected naproxen derivatives were investigated for their antinociceptive effects, using in vitro (COX‐I/COX‐II antagonistic effect), in vivo (acetic acid and hot plate assay), and in silico (molecular simulation studies) approaches. The COX inhibition studies revealed that the maximum percent effect exhibited by GMO‐I‐111a 96.01 and 92% against COX‐2 ...
Ubaidullah, Naveed Muhammad, Abad Khan, Rahaf Ajaj, Abdur Rauf, Umer Rashid, Fahad Hussain, Rashid Khan, Faiza Seraj, Uzma Uzma, Basharat Ali, Abdul Sadiq, Khalid Mohammed Khan, Marcello Iriti   +13 more
wiley   +1 more source

Radical Retrosynthesis of Natural Products Enabled by Iron‐Based Reductive Olefin Coupling

Angewandte Chemie Novit, Volume 2, Issue 1, March 2026.
This review highlights iron‐catalyzed reductive olefin coupling (ROC)—a strategy for C─C bond formation driven by metal‐hydride hydrogen atom transfer (MHAT)—as a key tool in natural products synthesis. This review surveys dozens of total syntheses employing ROC‐based strategies, highlighting its power to forge strained rings, quaternary centers, and ...
Griffin L. Barnes, Alex L. Rerick, Phil S. Baran   +2 more
wiley   +1 more source

Synthesis under Microwave Irradiation of [1,2,4]Triazolo[3,4-b] [1,3,4]thiadiazoles and Other Diazoles Bearing Indole Moieties and Their Antimicrobial Evaluation

Molecules, 2011
Microwave-assisted synthesis of some novel compounds, namely, 3-(2-methyl-1H-indol-3-yl)-6-aryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles 5a,b was accomplished via bromination of 2-methyl-3-[4-(arylideneamino)-5-mercapto-4H-[1,2,4]triazol-3-yl]-1H ...
Sobhi M. Gomha, Sayed M. Riyadh
doaj   +1 more source

Studies on Synthesis of Pyrimidine Derivatives and their Pharmacological Evaluation

E-Journal of Chemistry, 2007
1,3,4-Oxadiazoles were associated with broad spectrum of biological activities including antituberculosis, anticonvulsant, anti-inflammatory, insecticidal, antifungal, analgesic and antitumor properties. Morpholine derivatives find their wide spectrum of
T. A. Naik, K. H. Chikhalia
doaj   +1 more source

Synthesis, Cytotoxicity, Xanthine Oxidase Inhibition, Antioxidant of New Pyrazolo{3,4 d}Pyrimidine Derivatives

مجلة بغداد للعلوم, 2019
Allopurinol derivative were prepared by reacting the (1-chloroacetyl)-2-Hydropyrazolo{3,4-d}pyrimidine-4-oneiwith 5- methoxy- 2-aminoibenzothiazoleiunder certain conditions to obtain new compound  ( N- (2-aminoacetyl (5-methoxy) benzothiazole -2yl) (A4),
Khammas et al.
doaj   +1 more source

Synthesis, Characterization and study biologicalactivity of several 1-cyclopentene-1,2-dicarboxylimidyl Containing oxadiazole and Benzothiazole

مجلة بغداد للعلوم, 2014
In this work involved prepared of several new 1-cyclopentene-1,2-dicarboxylimide linked to oxadiazole and benzothiazole moiety were synthesized by two steps: The first step 2-amino-substituted-1,3,4-oxadiazoles and substituted-2-aminobenzothiazole were ...
Baghdad Science Journal
doaj   +1 more source

Improved Protocol Toward 1,3,4-Oxadiazole-2(3H)-thiones and Scale-up Synthesis in the Presence of SDS as a Micelle Promoted Catalyst

Acta Chimica Slovenica, 2015
Convenient procedure for in situ cyclization of hydrazinecarbodithioate potassium salts to 1,3,4-oxadiazole-2(3H)-thiones under normal phase micellar media catalysis promoted by sodium dodecyl sulfate (SDS) as an anionic surfactant is reported.
Ayhan YILDIRIM
doaj   +1 more source

Molecular Structure, Matrix-Isolation IR Spectrum and UV-Induced Transformations of 2-Amino-5-(4-Methoxyphenyl)-1,3,4-Oxadiazole

Molecules
The photochemistry of 1,3,4-oxadiazoles remains poorly understood, despite their recognized importance in medicinal chemistry and materials science. In this work, we report a detailed matrix-isolation study of 2-amino-5-(4-methoxyphenyl)-1,3,4-oxadiazole,
İsa Sıdır, Susy Lopes, Rui Fausto, A. J. Lopes Jesus   +3 more
doaj   +1 more source

Synthesis, Reactions and Antioxidant Activity of 5-(3', 4'-dihydroxy-tetrahydrofuran-2'-yl)-2-methyl-3-carbohydrazide [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2019
In this manuscript, we describe the synthesis of the carbohydrazide 2. Acid-catalyzed condensation with several carbonyl compounds to afford the corresponding carbohydrazide derivatives 3-12.
Mohamed El Sadek, Samir Ahmed Magd, Seham Yassen Hassan, Mohamed A. Mostafa, Galile Yacouat   +4 more
doaj  

Synthetic Approaches to 1,3,4-Oxadiazole-Containing Boronic Derivatives

Applied Sciences
1,3,4-Oxadiazoles containing boronic acid moieties are promising as a highly versatile class of compounds with significant utility across various scientific domains.
Barbara Wołek, Agnieszka Kudelko
doaj   +1 more source