In Silico, In Vitro, and In Vivo Antinociceptive Potential of S‐Naproxen Derivatives
Selected naproxen derivatives were investigated for their antinociceptive effects, using in vitro (COX‐I/COX‐II antagonistic effect), in vivo (acetic acid and hot plate assay), and in silico (molecular simulation studies) approaches. The COX inhibition studies revealed that the maximum percent effect exhibited by GMO‐I‐111a 96.01 and 92% against COX‐2 ...
Ubaidullah +13 more
wiley +1 more source
Síntese de cristais líquidos funcionalizados contendo o heterociclo 1,3,4-oxadiazol [PDF]
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2013.Neste trabalho são descritas a síntese, a caracterização e os estudos das propriedades ópticas,
Westphal, Eduard
core
Microwave Irradiation Promoted Reactions of Orthoesters with Carboxylic Acid Hydrazides. Preparation of 1,3,4-Oxadiazoles [PDF]
Rapid and highly efficient synthesis of 2- or 2,5-substituted 1,3,4-oxadiazoles by the condensation of aryl carboxylic acid hydrazides and orthoesters can be achieved under microwave irradiation using an unmodified commercial over in unsealed vessels.
Mohammad Sadegh Khajavi +2 more
doaj
Heterocycles from saccharide hydrazones. Part I. Saccharide 1,3,4-oxadiazoles
Oxidation, with iodine-mercuric oxide, of acetylated saccharide aroylhydrazones and of aromatic aldehyde hydrazones yields 5-aryl-2-(polyacetoxyalkyl)-1,3,4-oxadiazoles and 2,5-diaryl-1,3,4-oxadiazoles, respectively.
H. El Khadem +5 more
core +1 more source
Intramolecular Diels−Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles
Full details of a systematic exploration of the intramolecular [4 + 2]/[3 + 2] cycloaddition cascade of 1,3,4-oxadiazoles are disclosed in which the scope and utility of the reaction are ...
James R. Fuchs (143921) +6 more
core +2 more sources
Síntese e caracterização de cristais liquidos tipo bastão de hockey [PDF]
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Físicas e Matemáticas. Curso de Química.Este trabalho tem como objetivo geral a síntese de cristais líquidos termotrópicos, com forma semelhante a bastões de hockey contendo o ...
VIEIRA , André Alexandre
core
Synthesis, antibacterial activity and in silico study of new bis(1,3,4-oxadiazoles)
In the current study, new bis(2,5-disubstituted 1,3,4-oxadiazoles) linked to aliphatic cores were efficiently prepared. For this purpose, the appropriate bis(aldehydes) and benzohydrazides were reacted to produce the corresponding bis(N-benzoylhydrazones)
Ahmed E. M. Mekky (6618713) +2 more
core +1 more source
Síntese de novos cristais líquidos iônicos calamíticos luminescentes [PDF]
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Físicas e Matemáticas. Curso de Química.Cristais líquidos (CL) têm se tornado um campo cada vez mais atraente devido as aplicações em materiais eletrônicos moleculares da atual ...
SILVA, Danilo Henrique de
core
2-Alkenyl-1,3,4-oxadiazole derivatives have been prepared by cross-coupling of 1,3,4-oxadiazoles with styrenes by using palladium(II) trifluoroacetate [Pd(TFA)2] as a catalyst, 1,10-phenanthroline as a ligand, silver trifluoroacetate as an oxidant, and ...
Biswanath Das, N. Salvanna, P. Reddy
core +1 more source
Synthesis and fluorescence studies of porphyrin appended 1,3,4-oxadiazoles
A modular synthetic approach for preparing a family of porphyrin appended 1,3,4-oxadiazoles 9 is described. The porphyrin hydrazides are reacted with aryl aldehydes in presence of Yb(OTf)3 as catalyst to give porphyrin hydrazones 8 which are then ...
Dalip Kumar +5 more
core +1 more source

