Results 91 to 100 of about 37,093 (255)

Exploring Novel Nitrofuryl‐1,3,4‐Thiadiazole‐Based Derivatives: Design, Synthesis, and Evaluation of In Vitro Leishmanicidal and Trypanocidal Activity

Archiv der Pharmazie, Volume 359, Issue 3, March 2026.
In a series of substituted 1‐[5‐(5‐nitrofuran‐2‐yl)‐1,3,4‐thiadiazol‐2‐yl]piperidine‐4‐carboxamides evaluated for in vitro antileishmanial and antitrypanosomal activity, compound 18 emerged as the most promising derivative, showing submicromolar anti‐parasitic effects targeting diverse Leishmania and Trypanosoma species and acceptable selectivity ...
Alireza Mousavi, Martina Slapničková, Maryam Norouzbahari, Sarah D'Alessandro, Parham Foroumadi, Fariba Peytam, Federica Perego, Eva Doleželová, Zahra Emamgholipour, Maliheh Barazandeh Tehrani, Seyed Esmaeil Sadat‐Ebrahimi, Elahe Hosseinzadeh, Elmira Meghrazi Ahadi, Loghman Firoozpour, Hamidreza Bijanzadeh, Nicoletta Basilico, Alena Zíková, Alireza Foroumadi   +17 more
wiley   +1 more source

Chromaticity Control in Light‐Emitting Electrochemical Cells via Thermally Activated Emission in Assemblies of a BN‐Doped Pyrenyl Hydrocarbon

Advanced Functional Materials, Volume 36, Issue 5, 15 January 2026.
The successful color control in light‐emitting electrochemical cells based on highly emissive green‐emitting BN‐doped polyaromatic hydrocarbon with thermally activated NIR emitting assemblies. Abstract This work outlines the synthesis and photo‐/electro‐luminescent behavior of a new C‐shaped BN‐doped benzenoid hydrocarbon using N‐directed borylation in
Luca M. Cavinato, Marco Franceschini, Laura Caputo, Jean‐Christophe Charlier, Marc de Wergifosse, Davide Bonifazi, Rubén D. Costa   +6 more
wiley   +1 more source

Molecular Docking Studies of 2-Mercapto-5-(3-Methoxyphenyl) 1, 3, 4 Oxadiazole Thiones with Focal Adhesion Kinase [PDF]

, 2014
The main objective of the present work is to perform molecular docking studies of the ligand 2- Mercapto-5-(3-Methoxy phenyl) 1,3,4 oxadiazole with protein focal adhesion kinase. A good correlation was observed in binding affinity of this complex.
Guruprasad, R., Kiran, K.S., Kokila, M.K.   +2 more
core  

Microwave Irradiation Promoted Reactions of Orthoesters with Carboxylic Acid Hydrazides. Preparation of 1,3,4-Oxadiazoles [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1997
Rapid and highly efficient synthesis of 2- or 2,5-substituted 1,3,4-oxadiazoles by the condensation of aryl carboxylic acid hydrazides and orthoesters can be achieved under microwave irradiation using an unmodified commercial over in unsealed vessels.
Mohammad Sadegh Khajavi, Seyed Saheb Sadat Hosseini, Fatemeh Sefidkon   +2 more
doaj  

Insilico design, ADMET screening, MM-GBSA binding free energy of novel 1,3,4 oxadiazoles linked Schiff bases as PARP-1 inhibitors targeting breast cancer

Future Journal of Pharmaceutical Sciences, 2021
Background Poly(ADP-ribose) polymerases (PARPs), a nuclear protein belongs to a new class of drugs, which mainly target tumours with DNA repair defects.
Narayan Shridhar Deshpande, Gowdru Srinivasa Mahendra, Natasha Naval Aggarwal, Banylla Felicity Dkhar Gatphoh, Bistuvalli Chandrashekharappa Revanasiddappa   +4 more
doaj   +1 more source

Synthesis and Quantitative Structure–Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6-Methylguanine-DNA-methyltransferase, DNA Mismatch Repair and p53. [PDF]

, 2013
The antitumor prodrug Temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (EC 2.1.1.63, MGMT). Tumor
Arris C. E., Arrowsmith J., Barvaux V. A., Boberg F., Boyd M. R., Bunz F., Damera K., Darkes M. J. M., De K., Denny B. J., Dimitrios Pletsas, Dinca E. B., Elrashied A. E. Garelnabi, Garelnabi E. A. E., Hirose Y., Honnalli S. S., Judson P. L., Karran P., Karran P., Kotera M., Leteurtre F., Li Li, Liu L., McElhinney R. S., McGarrity J. F., Mladek A. C., Nishizuka S., Pletsas D., Richard T. Wheelhouse, Roger M. Phillips, Sarkaria J. N., Schmidt B. F., Schmiedekamp A., Shealy Y. F., Siddiqui A. A., Smith R. H., Stevens M. F. G., Svilar D., Wang Y., Wheelhouse R. T., Wheelhouse R. T., Zhang J., Zhang J.   +42 more
core   +1 more source

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source

Symmetric 3,5-Pyrazole and Isoxazole Heterocycles Comprising a Bent Core Unit: Synthesis and Mesomorphic Characterisation [PDF]

, 2015
The synthesis and characterisation of some new liquid crystalline (LC) heteroaromatic compounds containing the five-membered pyrazole/isoxazole rings is reported. Some of the compounds exhibited enantiotropic LC properties.
Hariprasad, S., Srinivasa, H.T.
core   +1 more source

Design, Synthesis and Evaluation of New Bioactive Oxadiazole Derivatives as Anticancer Agents Targeting Bcl-2 [PDF]

, 2020
A series of 2-(1H-indol-3-yl)-5-substituted-1,3,4-oxadiazoles, 4a–m, were designed, synthesized and tested in vitro as potential pro-apoptotic Bcl-2 inhibitory anticancer agents based on our previously reported hit compounds.
El-Sadek, Mohamed, Elseginy, Samia A., Hamdy, Rania, Jones, Arwyn T., Lashin, El-Said, Westwell, Andrew D., Ziedan, Noha   +6 more
core   +4 more sources

A New Class of Benzo[b]Thiophene‐1,3,4‐Oxadizole Bearing 1,2,4‐Oxadiazoles as Potent Antimicrobial Targets: Synthesis, Biological Evaluation, Docking, DFT and ADMET Studies

ChemistrySelect, Volume 11, Issue 3, 22 January 2026.
Benzo[b]thiophene‐1,3,4‐oxadizole and 1,2,4‐oxadiazole hybrids 9a–9l were tested against both antibacterial and anticancer, revealing interesting structure‐activity relationships. density functional theory calculations (DFTs) at the B3LYP/6–311++G (d,p).
Ravikumar Gupta Miriyala, Janardan Sannapaneni, Phani Raja Kanuparthy, Venkata Ramana Singamaneni, Tejeswara Rao Allaka, Pilli Veera Venkata Nanda Kishore   +5 more
wiley   +1 more source