Results 101 to 110 of about 37,093 (255)

An Efficient and Epimerization Free Synthesis of C-Terminal Arylamides Derived from α-Amino Acids and Peptide Acids via T3p Activation [PDF]

, 2014
A high yield and rapid synthesis of enantiomerically pure N α -protected amino/peptide acid arylamides using n-propylphosphonic anhydride (T3P) in presence of N-methylmorpholine is described.
Chilakapati Madhu, ., Narendra, N., Panguluri Nageswararao, ., Vommina, V. Sureshbabu   +3 more
core   +2 more sources

Advances in Palladium‐Catalyzed Suzuki–Miyaura Cross‐Coupling Strategies for Heterocyclic Synthesis: Focus on Pyridines, Indoles, and Quinolines

Journal of Chemistry, Volume 2026, Issue 1, 2026.
This review aims to summarize recent developments (2020–2025) in the use of Suzuki–Miyaura cross‐coupling reactions for the synthesis and functionalization of pyridine, indole, and quinoline derivatives—three classes of heterocycles known for their wide‐ranging biological and pharmacological significance.
Shreyas Krishna K., Padmapriya M., Manjunath R., Santosh L. Gaonkar, Munmun Bardhan   +4 more
wiley   +1 more source

Designing of Promising VEGFR‐2 Inhibitors by Using QSAR Modeling, Molecular Docking, and Molecular Dynamic Simulation: Implications Toward the Treatment of Cancer

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Background The vascular endothelial growth factor receptor 2 (VEGFR‐2) is considered one of the most studied therapeutic targets for the treatment of various cancers. Among many heterocyclic compounds, the oxadiazole derivatives have been reported to exhibit significant anticancer activities. Therefore, exploring these derivatives against VEGFR‐2 could
Aisha A. Alsfouk, Pervaiz Ali Channar, Muhammad Sajjad Bilal, Syeda Abida Ejaz, Song J. A. Kim, Sohini Basu Roy   +5 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Novel 5-Substituted-2-(3,4,5-trihydroxyphenyl)-1,3,4-oxadiazoles as Potent Antioxidants

, 2016
A novel series of 5-(5-substituted-1,3,4-oxadiazol-2-yl)benzene-1,2,3-triols (3n-z) was designed, synthesized, and evaluated for its potential antioxidant activities.
A. M. Rabie, Atif S. Tantawy, Sahar M. I. Badr   +2 more
semanticscholar   +1 more source

Synthetic Strategies to Access Fluorinated Azoles

European Journal of Organic Chemistry, Volume 28, Issue 47, December 15, 2025.
This review highlights recent synthetic strategies for introducing fluorine groups (mono‐, di‐, and trifluoromethylation) into 11 major azole classes, identifying research gaps to inform future innovations in materials science, medicinal chemistry, and biomedical research.
Mohammed K. Abd El‐Gaber, Mario Djugovski, Tzu‐Yu Huang, Sweta Adhikari, Sudeshna Roy   +4 more
wiley   +1 more source

Síntese de ligantes fotoluminescentes derivados do heterociclo 1,3,4-oxadiazol [PDF]

, 2005
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Físicas e Matemáticas. Curso de Química.A síntese, de novos compostos fotoluminescentes contendo o heterociclo 1,3,4-oxadiazol são descritas.
FRIZON, Tiago Elias Allievi
core  

Synthesis under Microwave Irradiation of [1,2,4]Triazolo[3,4-b] [1,3,4]thiadiazoles and Other Diazoles Bearing Indole Moieties and Their Antimicrobial Evaluation

Molecules, 2011
Microwave-assisted synthesis of some novel compounds, namely, 3-(2-methyl-1H-indol-3-yl)-6-aryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles 5a,b was accomplished via bromination of 2-methyl-3-[4-(arylideneamino)-5-mercapto-4H-[1,2,4]triazol-3-yl]-1H ...
Sobhi M. Gomha, Sayed M. Riyadh
doaj   +1 more source

Silica-supported dichlorophosphate: a recoverable cyclodehydrant for the eco-friendly synthesis of 2,5-disubstituted 1,3,4-oxadiazoles under solvent-free and microwave irradiation conditions [PDF]

, 2008
A series of symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles were efficiently synthesized from the cyclodehydration of diacylhydrazines by using silica-supported dichlorophosphate as a recoverable cyclodehydrant in solvent-free medium ...
Anguo Zhu, Xiunan Sun, Xue Gong, Xuerong Mao, Zheng Li   +4 more
core   +1 more source

Studies on Synthesis of Pyrimidine Derivatives and their Pharmacological Evaluation

E-Journal of Chemistry, 2007
1,3,4-Oxadiazoles were associated with broad spectrum of biological activities including antituberculosis, anticonvulsant, anti-inflammatory, insecticidal, antifungal, analgesic and antitumor properties. Morpholine derivatives find their wide spectrum of
T. A. Naik, K. H. Chikhalia
doaj   +1 more source

Synthesis, Cytotoxicity, Xanthine Oxidase Inhibition, Antioxidant of New Pyrazolo{3,4 d}Pyrimidine Derivatives

مجلة بغداد للعلوم, 2019
Allopurinol derivative were prepared by reacting the (1-chloroacetyl)-2-Hydropyrazolo{3,4-d}pyrimidine-4-oneiwith 5- methoxy- 2-aminoibenzothiazoleiunder certain conditions to obtain new compound  ( N- (2-aminoacetyl (5-methoxy) benzothiazole -2yl) (A4),
Khammas et al.
doaj   +1 more source