Results 71 to 80 of about 37,093 (255)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur   +6 more
wiley   +1 more source

A convergent synthesis of 1,3,4-oxadiazoles from acyl hydrazides under semiaqueous conditions. [PDF]

open access: yesChem Sci, 2017
An innovative new synthesis approach to disubstituted 1,3,4-oxadiazoles is described, inspired by Umpolung Amide Synthesis (UmAS).
Tokumaru K, Johnston JN.
europepmc   +2 more sources

Design, Synthesis, and Biological Evaluation of Novel Triazine‐Based Dual Histone Deacetylase/phosphatidylinositol 3‐kinase Inhibitors for Breast Cancer Therapy

open access: yesChemMedChem, Volume 21, Issue 8, 28 April 2026.
Breast cancer is the most frequently diagnosed malignancy and a leading cause of cancer‐related mortality among women worldwide. Triple‐negative breast cancer (TNBC) poses a major clinical challenge due to its aggressive nature, limited therapeutic options, and high propensity for drug resistance.
Lara Luzietti   +9 more
wiley   +1 more source

Multipurpose Transparent Nanocomposites for Gamma Spectroscopy, Pulse Shape Discrimination, Thermal Neutron Detection, Radiation Shielding, and High Refractive Index Applications

open access: yesAdvanced Functional Materials, Volume 36, Issue 28, 7 April 2026.
Materials exist that are useful for gamma scintillation, radiation shielding, neutron‐gamma pulse shape discrimination (PSD), thermal neutron detection, or high refractive index applications. While certain materials have exhibited optimal performance for each of these applications, none achieve multiple functions.
Isabelle Winardi   +13 more
wiley   +1 more source

A triazole containing co-polymer for use as an electron transport material in multilayer LEDs [PDF]

open access: yes, 1997
We report investigations into a poly(1,20-(10,13-didecyl)distyrylbenzene-co-1,2-[p-ethylphenyl)]triazole) (TRIDSB) electron transport material and its incorporation into single and multilayer LEDs.
Bradley, DDC   +3 more
core   +1 more source

Multifunctional Oxadiazole‐Based Polycatenars: A Pathway to Polar Columnar Phases

open access: yesAdvanced Materials Interfaces, Volume 13, Issue 7, 7 April 2026.
Aromatic core fluorination directs oxadiazole‐based polycatenars into ferroelectric and antiferroelectric columnar phases with supergelation and photo‐responsiveness. ABSTRACT Polar columnar liquid crystals (LCs) offer a promising pathway to nanostructured architectures for next‐generation ferroelectric devices.
Yu Cao   +7 more
wiley   +1 more source

Expeditious synthesis of 1,3,4-oxadiazole derivatives via sydnones [PDF]

open access: yesJournal of the Serbian Chemical Society, 2008
The clean cyclization of chalcones (1a-c/2a-c) with hydrazine hydrate under microwave irradiation afforded pyrazolines derivatised with sydnone (3d-i/4d-i), which underwent 1,3-dipolar cyclo-addition with acetic anhydride to form pyrazolines appended ...
Kamble Ravindra R.   +2 more
doaj   +3 more sources

Targeted synthesis and in vitro bactericidal and fungicidal activities of 2-alkylthio-5-(p-aminophenyl)-1,3,4-oxadiazoles.

open access: yesJournal of Basic and Applied Research in Biomedicine, 2022
Selective alkylation of 5-(p-aminophenyl)-1,3,4-oxadiazol-2(3H)-thione with alkyl halides have been studied. It was revealed that alkylation goes on more polarized thiogroup in position 2 and corresponding 2-alkylthio-1,3,4-oxadiazoles were obtained in ...
D Ismailova   +5 more
doaj   +2 more sources

Synthetic chemistry and biological activity of pentafluorosulphanyl (SF5) organic molecules [PDF]

open access: yes, 2012
Acknowledgements We thank the European Commission for financial support (Industry Academia Partnerships and Pathways project “PET BRAIN”, Contract No 251482). S.A.
Altomonte, Stefano, Zanda, Matteo
core   +1 more source

Excimer Formation in Aqueous Solutions of Hosts and Application in Synthesis

open access: yesChemPhotoChem, Volume 10, Issue 4, April 2026.
This review explores how host‐mediated excimer formation in water, facilitated by supramolecular confinement enhances photochemical synthesis. By improving solubility, local concentrations, and orientational control, these systems can boost efficiency and selectivity in reactions like photocycloadditions and photodimerizations.
Doğan Akbulut   +3 more
wiley   +1 more source

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