Results 81 to 90 of about 8,042 (202)

Synthesis, Biological Evaluation, and Molecular Modeling Studies of New Thiadiazole Derivatives as Potent P2X7 Receptor Inhibitors

Frontiers in Chemistry, 2019
Twenty new 2-(1H-pyrazol-1-yl)-1,3,4-thiadiazole analogs were synthetized to develop P2X7 receptor (P2X7R) inhibitors. P2X7R inhibition in vitro was evaluated in mouse peritoneal macrophages, HEK-293 cells transfected with hP2X7R (dye uptake assay), and ...
Daniel T. G. Gonzaga, Daniel T. G. Gonzaga, Felipe H. Oliveira, N. L. von Ranke, G. Q. Pinho, Juliana P. Salles, Murilo L. Bello, Carlos R. Rodrigues, Helena C. Castro, Hellen V. C. M. de Souza, Caroline R. C. Reis, Rennan P. P. Leme, João C. M. Mafra, Luiz C. S. Pinheiro, Lucas V. B. Hoelz, Nubia Boechat, Robson X. Faria   +16 more
doaj   +1 more source

Synthesis of Mesoionic 1,3,4-thiadiazoles

, 1968
Synthesis of Mesoionic 1,3,4 ...
P. B. Talukdar, S. K. Sengupta
openaire   +1 more source

A Drug Delivery to Improve Prognosis of Traumatic Brain Injury Mice Through Mouse‐Derived Nerve Growth Factor Coated by a Nanoparticle

CNS Neuroscience &Therapeutics, Volume 31, Issue 10, October 2025.
This study is the first to demonstrate that mNGF, when nanocrystallized, crosses the BBB more effectively in TBI mice, subsequently aiding the repair and functional recovery of the nervous system post‐injury. ABSTRACT Objective The large molecular weight and limited permeability of mouse‐derived nerve growth factor (mNGF) across the blood–brain barrier
Ruichen Zhao, Shiying Dong, Di Wu, Yu Tian, Jiangyuan Yuan, Liang Mi, Chenrui Wu, Shiao Tong, Rongcai Jiang   +8 more
wiley   +1 more source

Fibrous Pb(II)‐Based Coordination Polymer Operable as a Photocatalyst and Electrocatalyst for High‐Rate, Selective CO2‐to‐Formate Conversion

Advanced Functional Materials, Volume 35, Issue 28, July 10, 2025.
A coordination polymer [Pb(tadt)]n prepared by a microwave‐assisted solvothermal method selectively reduces CO2 into formate under visible light with a high apparent quantum yield of ≈25% at 400 nm. It can function as a pre‐catalyst, along with conductive Ketjen Black, to form an active PbCO3/Pb3(CO3)2(OH)2 mixture that exhibits a high Faradaic ...
Chomponoot Suppaso, Ryosuke Nakazato, Shoko Nakahata, Yoshinobu Kamakura, Fumitaka Ishiwari, Akinori Saeki, Daisuke Tanaka, Kazuhide Kamiya, Kazuhiko Maeda   +8 more
wiley   +1 more source

Synthesis and Antiviral Activity of 5‑(4‑Chlorophenyl)-1,3,4-Thiadiazole Sulfonamides

Molecules, 2010
Starting from 4-chlorobenzoic acid, 10 new 5-(4-chlorophenyl)-N-substituted-N-1,3,4-thiadiazole-2-sulfonamide derivatives were synthesized in six-steps. Esterification of 4-chlorobenzoic acid with methanol and subsequent hydrazination, salt formation and
Yuping Zhang, De-Yu Huang, Pinaki S. Bhadury, Weiming Xu, Huitao Fan, Song Yang, Keming Liu, Zhuo Chen   +7 more
doaj   +1 more source

A Second-Generation Janus Scorpionate Ligand: Controlling Coordination Modes in Iron(II) Complexes by Steric Modulation [PDF]

, 2008
The second-generation Janus scorpionate ligand [HB(mtdaMe)3−] containing methyl-mercaptothiadiazolyl (mtdaMe) heterocyclic rings and (N,N,N-) and (S,S,S-) binding pockets has been prepared. The effect of methyl substitution versus the unsubstituted first-
Gardinier, James R., Grandjean, Fernande, Gwengo, Chengeto, Lindeman, Sergey V., Long, Gary J., Silva, Rosalice M., Smith, Mark D.   +6 more
core   +1 more source

In Vitro and In Silico Evaluation of Isatin‐Derived Spirooxindoles as Antituberculosis Drug Candidates

Chemical Biology &Drug Design, Volume 106, Issue 1, July 2025.
Two compounds, A16 and A17, were active against multidrug‐resistant Mycobacterium tuberculosis isolates (PT‐12 and PT‐20), overcoming key resistance mutations in katG and rpoB, while cytotoxicity assays confirmed that they are non‐toxic. A17 exhibited the highest antituberculosis activity, with molecular docking suggesting enoyl‐[acyl‐carrier‐protein ...
Fernanda Rodrigues de Lima, Jéssika de Oliveira Viana, Aleff Cruz de Castro, Rodrigo Cristiano, Marcia Alberton Perelló, Alexia de Matos Czeczot, Cristiano Valim Bizarro, Pablo Machado, Luiz Augusto Basso, Claudio Gabriel Lima‐Junior, Valnês da Silva Rodrigues‐Junior, Karen Cacilda Weber   +11 more
wiley   +1 more source

Synthesis, Characterization and Antibacterial Activity of New Chalcones Derived from New Aldehyde; 4-[5-(4`tolyl)-1,3,4-thiadiazole-2-yl] benzaldehyde

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
 New chalcones of  -{ -  -   -   y  -     - hi di z  e- -y    he y  - -    e e- -  e-    -        - substituted phenyl have been prepared from condensation of  a new of  4-[5-(4`-tolyl)1,3,4-thiadiazole-2-yl] benzaldehyde (which is synthesized by the ...
Jumbad H. Tomma., Mustafa S. Khazaal, Rajaa K. Baker   +2 more
doaj   +1 more source

Synthesis, Characterisation And Cytotoxicity Study Of Some New 1,2,4-Triazole Derivatives [PDF]

, 2017
Dalam kajian ini, 36 sebatian baru 1,2,4-triazol dengan sistem gelang mono dan terlakur telah disintesis dan dicirikan In this study, 36 new 1,2,4-triazole compounds with mono and fused ring system have been synthesised and ...
Mohsin Slaihim, Mukhlif
core  

Synthesis of new 2,5-disubstituted-1,3,4-thiadiazole derivatives and their in vivo anticonvulsant activity [PDF]

, 2014
A series of 2,5-disubstituted-1,3,4-thiadiazole derivatives were synthesized by the reaction of 3-(2-cyanopropan-2-yl)-N-(5-(piperazine-1-yl)-1, 3,4-thiadiazol-2-yl)benzamide with various sulfonyl chlorides and evaluated for their anticonvulsant activity
Harish, K. P., Mallesha, L., Mohana, K. N.   +2 more
core   +1 more source