Results 121 to 130 of about 4,494 (179)

Iodocyclization of 1,4-dihydropyridines

Tetrahedron Letters, 1998
Abstract Iodine (or related species) addition to 1,4-dihydropyridines, with properly attached substituents at the nitrogen atom, leads to the corresponding 3-iodotetrahydropyridinium ions, which undergo an internal nucleophilic attack to furnish regio- and stereoselectively iodobi(poly)lteterocyclic ring systems in good yields.
Rodolfo Lavilla, Oscar Coll, Marta Nicolàs, Joan Bosch   +3 more
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The oxidation of 1,4-dihydropyridines

Chemistry of Heterocyclic Compounds, 1970
The olefinic bond of methenylbisindan-1,3-dione, 2-benzylideneindan-1, 3-dione, and its derivatives is easily reduced by many 1, 4-dihydropyridines. Under the conditions described, other functional groups are untouched. These Β-dicarbonyl compounds are utilized to compare the effects of substituents in 1,4-dihydropyridines on their reactivity in the ...
G. Ya. Dubur, Ya. R. Uldrikis
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1,4-Dihydropyridines and the 1,4-Dihydropyridine Receptor

1993
The 1,4-dihydropyridine nifedipine is a first-generation drug of major significance in the treatment of cardiovascular disorders including hypertension, peripheral vascular disorders and angina in its several forms. Nifedipine is one of a chemically and pharmacologically heterogeneous group of drugs that includes also verapamil and diltiazem and which ...
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Aromatization of 1,4‐Dihydropyridines with Selenium Dioxide.

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Xiao-hua Cai, Hai-jun Yang, Guo-lin Zhang   +2 more
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The photochemistry of 3,5-disubstituted 1,4-dihydropyridines

Tetrahedron, 1970
Abstract On irradiation, 1,4-dihydropyridines have been shown to undergo three types of reaction: disproportionation, isomerization and dimerization. The presence of 2,6-substituents inhibits these reactions except in the case of 3a which undergoes disproportionation.
U, Eisner, J R, Williams, B W, Matthews, H, Ziffer   +3 more
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1,4-Dihydropyridine activators in the tiamdipine series

European Journal of Pharmacology, 1990
The pharmacologic and radioligand binding properties of 5-nitro analogs of the 1,4-dihydropyridine Ca2+ channel antagonist, tiamdipine (2-(2-aminoethylthio)methyl-3-carbomethoxy-5-carbomethoxy-6-m ethyl-4-(3-nitrophenyl)-1,4-dihydropyridine) and its N-formyl derivative have been measured in rat tail artery, guinea pig ileum and rat heart.
GALLETTI, FERRUCCIO, Luchowski E, Triggle DJ   +2 more
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The 1,4-Dihydropyridine Receptor

Journal of Cardiovascular Pharmacology, 1984
Evidence that nitrendipine (2,6-dimethyl-3-carbomethoxy-5-carbomethoxy-4-(3-nitrophenyl)1,4- dihydropyridine) and other 1,4-dihydropyridines interact at a specific site to antagonize Ca2+ channel function is reviewed. This evidence derives from electrophysiologic and pharmacologic studies and is confirmed by [3H]radioligand binding to excitable tissues.
D J, Triggle, R A, Janis
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Photoprotection of 1,4-dihydropyridine derivatives by dyes

International Journal of Pharmaceutics, 2005
The possibility of increasing the photochemical stability of nisoldipine by using indigotine and azorubine as photoprotectors has been studied. The course of the photodegradation was monitored by means of UV-vis spectrophotometry and HPLC. Quantitative assessments of the nisoldipine photodegradation included evaluation of the quantum yields and kinetic
Jadwiga, Mielcarek, Włodzimierz, Augustyniak, Paweł, Grobelny, Grazyna, Nowacka   +3 more
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Synthesis of Bis‐1,4‐dihydropyridine Derivatives.

ChemInform, 2005
Abstract A series of bis‐1,4‐dihydropyridine derivatives were synthesized by the reaction of p‐phenylenedialdehyde or m‐phenylenedialdehyde and active methylene compounds.
Songlei Zhu, Shujang Tu, Yuan Gao, Chunbao Miao, Tuanjie Li, Xiaojing Zhang, Fang Fang, Daqing Shi   +7 more
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Cocrystals of diastereoisomers of 1,4-dihydropyridine derivatives

Acta Crystallographica Section C Crystal Structure Communications, 2006
A mixture of the RR/SS and RS/SR diastereoisomeric pairs of methyl 4-(2,4-dichlorophenyl)-2,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, C 19 H 19 Cl 2 NO 3 , forms cocrystals in which there is one unique molecule in the asymmetric unit, but the molecule displays disorder in the region of the 7-position of the quinoline ring system as
Gunduz, MİYASE GÖZDE, SAFAK, C, SIMSEK, RAHİME, Linden, A   +3 more
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