Results 161 to 170 of about 370,384 (214)
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The photochemistry of 3,5-disubstituted 1,4-dihydropyridines
Tetrahedron, 1970Abstract On irradiation, 1,4-dihydropyridines have been shown to undergo three types of reaction: disproportionation, isomerization and dimerization. The presence of 2,6-substituents inhibits these reactions except in the case of 3a which undergoes disproportionation.
U, Eisner +3 more
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The 1,4-Dihydropyridine Receptor
Journal of Cardiovascular Pharmacology, 1984Evidence that nitrendipine (2,6-dimethyl-3-carbomethoxy-5-carbomethoxy-4-(3-nitrophenyl)1,4- dihydropyridine) and other 1,4-dihydropyridines interact at a specific site to antagonize Ca2+ channel function is reviewed. This evidence derives from electrophysiologic and pharmacologic studies and is confirmed by [3H]radioligand binding to excitable tissues.
D J, Triggle, R A, Janis
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Photoprotection of 1,4-dihydropyridine derivatives by dyes
International Journal of Pharmaceutics, 2005The possibility of increasing the photochemical stability of nisoldipine by using indigotine and azorubine as photoprotectors has been studied. The course of the photodegradation was monitored by means of UV-vis spectrophotometry and HPLC. Quantitative assessments of the nisoldipine photodegradation included evaluation of the quantum yields and kinetic
Jadwiga, Mielcarek +3 more
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Synthesis of Bis‐1,4‐dihydropyridine Derivatives.
ChemInform, 2005Abstract A series of bis‐1,4‐dihydropyridine derivatives were synthesized by the reaction of p‐phenylenedialdehyde or m‐phenylenedialdehyde and active methylene compounds.
Songlei Zhu +7 more
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Cocrystals of diastereoisomers of 1,4-dihydropyridine derivatives
Acta Crystallographica Section C Crystal Structure Communications, 2006A mixture of the RR/SS and RS/SR diastereoisomeric pairs of methyl 4-(2,4-dichlorophenyl)-2,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, C 19 H 19 Cl 2 NO 3 , forms cocrystals in which there is one unique molecule in the asymmetric unit, but the molecule displays disorder in the region of the 7-position of the quinoline ring system as
Gunduz, MİYASE GÖZDE +3 more
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1,4-Dihydropyridines bearing a pharmacophoric fragment of lidoflazine
Bioorganic & Medicinal Chemistry, 1996A series of 1,4-dihydropyridines bearing a pharmacophoric fragment of lidoflazine was synthesized. The compounds were evaluated for inotropic, chronotropic, and calcium antagonist activities. All compounds behave as inotropic and chronotropic agents, except for compounds 4b, 5a, and 5b, which exhibit a rather weak calcium antagonism in vascular smooth ...
Chiarini A. +5 more
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Reactions of 1,4-dihydropyridines (review)
Chemistry of Heterocyclic Compounds, 1993The literature published over the period 1986–1990 on the chemical properties (oxidation, addition, substitution, reactions of the functional groups, etc.) of 1,4-dihydropyridines is correlated.
A. Sausin'sh, G. Dubur
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Vicinal diamination of 1,4-dihydropyridines
Chemical Communications, 1998Electrophilic interaction of iodine with N-alkyl-1,4-dihydropyridines 1 in the presence of secondary amines stereoselectively leads to the corresponding trans-2,3-diamino-1,2,3,4-tetrahydropyridines 2 in satisfactory yields (79–94%); the method allows the synthesis of piperidine, pyrrolidine, morpholine and piperazine derivatives.
Rodolfo Lavilla +4 more
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The alkylation of hantzsch 1,4‐dihydropyridines
Journal of Heterocyclic Chemistry, 1986AbstractThe reaction of carbanions derived from Hantzsch 1,4‐dihydropyridines with alkyl halides was studied and methods for mono‐ and di‐alkylation were devised.
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Journal of the American Chemical Society, 1965
Newell C. Cook, James E. Lyons
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Newell C. Cook, James E. Lyons
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