1α,25-(OH)2-D3 promotes osteoclast-precursor autophagy and osteoclast differentiation by promoting BECN1 transcription [PDF]
Genetics and Molecular Biology1α,25-(OH)2-D3 can promote autophagy of osteoclast precursors (OCPs), resulting in its pro-osteoclastogenic effect, which limits its anti-osteoporotic efficacy. To address the above challenges, we need to explore the targets of autophagy-enhancing effect
Xi Li, Hui Liu, Yunrong Zhu
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Optimal Dietary Levels of 1α-Hydroxycholecalciferol in Broiler Chickens from 1 to 42 Days of Age
The Journal of Poultry Science, 2020 1α-Hydroxycholecalciferol (1α-OH-D3) is an active vitamin D derivative. In this study, three experiments were conducted to evaluate the optimal dietary levels of 1α-OH-D3 in broiler chickens from 1 to 42 days of age.
Xue Yang +7 more
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Harnessing natural sunlight indoors: sensor-regulated therapeutic approach to enhance vitamin D status in humans [PDF]
Scientific ReportsVitamin D deficiency is a widespread global health issue, even in sun-rich regions like the United Arab Emirates (UAE), where environmental, behavioral, and cultural factors limit skin exposure to ultraviolet B (UVB) radiation.
Muhammad K. Hakeem +6 more
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Maternal and neonatal vitamin D metabolite profiling and its long-term impact on childhood growth: findings from the KLOTHO birth cohort [PDF]
Frontiers in EndocrinologyBackgroundVitamin D is increasingly recognized as a key modulator of growth, metabolism, and body composition in early life. However, the long-term impact of maternal vitamin D status and its multiple circulating forms on childhood anthropometry remains ...
Spyridon N. Karras +12 more
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Gene expression profiles in human and mouse primary cells provide new insights into the differential actions of vitamin D3 metabolites. [PDF]
PLoS ONE, 2013 1α,25-Dihydroxyvitamin D3 (1α,25(OH)2D3) had earlier been regarded as the only active hormone. The newly identified actions of 25-hydroxyvitamin D3 (25(OH)D3) and 24R,25-dihydroxyvitamin D3 (24R,25(OH)2D3) broadened the vitamin D3 endocrine system ...
Pentti Tuohimaa +8 more
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One Alpha-hydroxycholecalciferol Improves Growth Performance, Tibia Quality, and Meat Color of Broilers Fed Calcium- and Phosphorus-Deficient Diets [PDF]
Asian-Australasian Journal of Animal Sciences, 2012 An experiment was conducted to evaluate the effects of one alpha-hydroxycholecalciferol (1α-OH D3) on growth performance, tibia quality, and skin and meat color in broilers fed calcium (Ca)- and phosphorus (P)-deficient corn-soybean meal diets.
J. C. Han +12 more
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Journal of Mass Spectrometry and Advances in the Clinical Lab, 2022 Background: Although measurement of 25(OH)D3 is a routine analytical method to determine plasma vitamin D status, 1α,25(OH)2D3 is the biologically active form. Hence, simultaneous measurement of 25(OH)D3 and 1α,25(OH)2D3 could provide better insight into
Shan Xu +6 more
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Gene-Regulatory Potential of 25-Hydroxyvitamin D3 and D2
Frontiers in Nutrition, 2022 Human peripheral blood mononuclear cells (PBMCs) represent a highly responsive primary tissue that is composed of innate and adaptive immune cells.
Andrea Hanel +3 more
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PLoS ONE, 2023 Melioidosis is an infectious disease with high mortality rates in human, caused by the bacterium Burkholderia pseudomallei. As an intracellular pathogen, B.
Pohnratchada Mattrasongkram +6 more
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PLoS ONE, 2023 Vitamin D (VD) exerts a wide variety of biological functions including calcemic activity. VD nutritional status is closely associated with the onset and development of chronic diseases.
Miho Iwaki +7 more
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