Results 101 to 110 of about 659,249 (217)

Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia

Journal of Lipid Research, 2008
1α,25-Dihydroxyvitamin D3 [1,25(OH)2D3], a vitamin D receptor (VDR) ligand, regulates calcium homeostasis and also exhibits noncalcemic actions on immunity and cell differentiation. In addition to disorders of bone and calcium metabolism, VDR ligands are
Michiyasu Ishizawa, Manabu Matsunawa, Ryutaro Adachi, Shigeyuki Uno, Kazumasa Ikeda, Hiroyuki Masuno, Masato Shimizu, Ken-ichi Iwasaki, Sachiko Yamada, Makoto Makishima   +9 more
doaj   +1 more source

Chemical structures of DLAM derivatives 2a–d.

, 2023
Structures of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3 (1) and 1α,25-dihydroxyvitamin D3-26,23-lactam (DLAM-2).DOI: 10.6084/m9.figshare.23806737.
Yoshiaki Kanemoto (17628166), Shigeaki Kato (294800), Rino Tsutsumi (17628172), Miho Iwaki (17628163), Tomohiro Kurokawa (15031457), Kazuo Nagasawa (1685587), Koki Nojiri (17628169), Takahiro Sawada (184183)   +7 more
core   +1 more source

Systematic Optimization of an SLE-DAPTAD LC-MS/MS Workflow for Simultaneous Quantification of Low-Abundance Vitamin D₃ Metabolites in Plasma. [PDF]

Rapid Commun Mass Spectrom
ABSTRACT Rationale Liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis of vitamin D3 metabolites is analytically challenging because these compounds are structurally similar, strongly matrix‐associated, and have poor ionization efficiency.
Amirmostofian M, Wiese MD, Anderson PH, Hoffmann P.   +3 more
europepmc   +2 more sources

The NFkB pathway is down-regulated by 1α,25(OH)2-Vitamin D3 in endothelial cells transformed by Kaposi Sarcoma-associated herpes virus G protein coupled receptor

, 2012
We have previously demonstrated that 1α,25 dihydroxy-vitamin D3 (1α,25(OH)2D3) has antiproliferative effects on the growth of endothelial cells transformed by the viral G protein-coupled receptor associated to Kaposi sarcoma (vGPCR).
Berstuy, Annemieke, González Pardo, María Verónica, D'elía, Noelia Laura, Boland, Ricardo Leopoldo, Russo, Ana Josefa, Verónica Gonzalez-Pardo, Noelia D’Elia, Annemieke Verstuyf, Ricardo Boland, Ana Russo de Boland   +9 more
core   +1 more source

Levels of Serum 25(OH)VD3, HIF-1α, VEGF, vWf, and IGF-1 and Their Correlation in Type 2 Diabetes Patients with Different Urine Albumin Creatinine Ratio

Journal of Diabetes Research, 2016
Objective. To investigate changes in serum 25(OH)VD3, HIF-1α, VEGF, vWf, IGF-1, and their correlation in type 2 diabetes patients at different stages of diabetic kidney disease (DKD). Methods.
Ying Shao, Chuan Lv, Qin Yuan, Qiuyue Wang   +3 more
doaj   +1 more source

Recent Advances in Ionizing Radiation as a Nonequilibrium Chemical Field for Catalysis

Carbon and Hydrogen, EarlyView.
Ionizing radiation acts as a nonequilibrium chemical field that generates reactive species and structural perturbations. These radiation‐induced effects bridge catalytic material construction, including metal loading, framework evolution, defect engineering, and carbon‐network reorganization, with selective transformations such as oxidation, reduction,
Junhua Kuang, Zhuo Liu, Jinlong Wan, Wenjie Duan, Li Peng, Liuxuan Cao, Jia Yu, Jian‐Feng Li, Shuliang Yang   +8 more
wiley   +1 more source

Interface‐Engineered Li–Ni–O/Ni Heterostructures With Tunable Vacancies on Biochar Enable Biomass‐to‐Hydrogen Conversion

Carbon Energy, EarlyView.
This study shows that lithium induces Li–Ni–O/Ni heterostructures on biochar, creating oxygen vacancies and optimal acid–base environments that enhance steam activation and suppress carbon deposition. These interfacial effects and synergistic modulation lead to high hydrogen yields at moderate temperatures, providing a scalable catalyst design strategy
Jiali Guo, Jit Loong Cyrus Foo, Guicai Liu, Liya Ge, Andrei Veksha, Wei Ping Chan, Dean Song, Grzegorz Lisak   +7 more
wiley   +1 more source

Synthesis of 9‑Alkylated Calcitriol and Two 1α,25-Dihydroxy-9-methylene-10,19-dihydrovitamin D₃ Analogues with a Non-natural Triene System by Thermal Sigmatropic Rearrangements

, 2016
1α,25-(OH)2-9α-Methylvitamin D3 (4), the first known analogue of the natural hormone 1α,25-(OH)2D3 (3) with an alkyl substituent at C-9, and two 1α,25-(OH)2-9-methylene-10,19-dihydrovitamin D3 analogues (7 and 8) with an unprecedented non-natural triene ...
Rafal R. Sicinski (578262), Rita Sigüeiro (1991680), Antonio Mouriño (1451062), Urszula Kulesza (1665070)   +3 more
core   +1 more source

Synergistically Accelerating Zn2+ Transport and Desolvation Through Cation‐Deficient Ion Channels in High‐Performance Zn Metal Batteries

Carbon Energy, EarlyView.
The novel ITO protective layer enables ultra‐stable Zn metal anodes. By synergistically accelerating Zn2+ desolvation and Zn2+ transport via its unique structure, the ITO layer suppresses dendrites and side reactions. This results in exceptional stability for over 6000 h at 2 mA cm–2 and stable operation in Zn ||MnO2 full‐cell configurations.
Hyeongbeom Kang, Jung Been Park, Myeongcho Jang, Min Sang Kim, Seungho Yu, Dong‐Wan Kim   +5 more
wiley   +1 more source

Functional studies of the human 25-hydroxyvitamin D3-24-hydroxylase, CYP24A1 [PDF]

, 2015
Thesis (Ph.D, Biochemistry) -- Queen's University, 2010-06-07 14:46:40.409This thesis focuses on the cytochrome P450 CYP24A1, which catabolizes 1α,25-dihydroxyvitamin D3 (1α,25-(OH)2D3) via two pathways commencing with C24-, or C23-hydroxylation and
Kaufmann, Martin
core