Results 171 to 180 of about 3,850 (205)

Efficient synthesis of (+)-nojirimycin and (+)-1-deoxynojirimycin

Tetrahedron Letters, 1990
Abstract (+)-Nojirimycin ( 1a ) and (+)-1-deoxynojirimycin ( 2 ) have been prepared from 1,2-O-isopropylidene-α-D-glucofuranurono-6,3-lactone ( 3 ) by a route involving stereoselective reductive amination of 5-hydroxy-l,2-O-isopropylidene-α-D-xylo-hexofuranurono-6,3-lactone ( 5a )
Peter B. Anzeveno, Laura J. Creemer
openaire   +1 more source

N-Bridged 1-deoxynojirimycin dimers as selective insect trehalase inhibitors

Carbohydrate Research, 2014
A small set of N-bridged 1-deoxynojirimycin dimers has been synthesized and evaluated as potential inhibitors of insect trehalase from midge larvae of Chironomus riparius, porcine trehalase as the mammalian counterpart and α-amylase from human saliva.
CIPOLLA, LAURA FRANCESCA, SGAMBATO, ANTONELLA, FORCELLA, MATILDE EMMA, FUSI, PAOLA ALESSANDRA, PARENTI, PAOLO, Cardona, F, BINI, DAVIDE   +6 more
openaire   +2 more sources

Enzyme-catalyzed acylation of castanospermine and 1-deoxynojirimycin

Tetrahedron Letters, 1990
Abstract Several esters of the alkaloids deoxynojirimycin and castanospermine have been synthesized via subtilisin-catalyzed regioselective acylation in pyridine.
Deborah L. Delinck, Alexey L. Margolin
openaire   +1 more source

Asymmetric synthesis of fluorinated analogues of 1-deoxynojirimycin

Journal of the Chemical Society, Chemical Communications, 1993
Two epimeric 1,3,4-trideoxy-3-fluoronojirimycins are obtained through a total asymmetric synthesis starting from a non-carbohydrate precursor; two key-steps of the synthetic sequence are an intramolecular aminomercuration reaction and an oxidative demercuration process.
A. Arnone, BRAVO, PIERFRANCESCO, A. Donadelli, RESNATI, GIUSEPPE   +3 more
openaire   +2 more sources

Total synthesis of 3,3-difluorinated 1-deoxynojirimycin analogues

Tetrahedron, 2010
Difluorination of 1-deoxynojirimycin at position C(3) creates a competitive inhibitor 15 of 10 times higher activity against an α-glucosidase than the parent compound. Its screening against a panel of human cell lines showed a low cytotoxicity therefore making this compound an interesting candidate for further clinical investigations.
René Csuk, Erik Prell, Claudia Korb, Ralph Kluge, Dieter Ströhl   +4 more
openaire   +1 more source

Enzymatic Synthesis of High Purity Maltotetraose Using Moranoline(1-Deoxynojirimycin)

Bioscience, Biotechnology, and Biochemistry, 1993
(1993). Enzymatic Synthesis of High Purity Maltotetraose Using Moranoline(1-Deoxynojirimycin) Bioscience, Biotechnology, and Biochemistry: Vol. 57, No. 3, pp. 499-501.
S, Maruo, H, Yamamoto, M, Toda, N, Tachikake, M, Kojima, Y, Ezure   +5 more
openaire   +2 more sources

A Short and Practical Synthesis of 1-Deoxynojirimycin

Synthetic Communications, 1991
Abstract The potent glucosidase inhibitor 1-deoxynojirimycin was synthesized from L-sorbose using a short synthesis and only one protecting group. The last step, which constituted the removal of an acetonide protecting group and an intramolecular reductive amination, was accomplished on an acidic lon-exchange resin. This provided a synthesis capable of
James Behling, Payman Farid, John R. Medich, Mike G. Scaros, Michael Prunier, Richard M. Weier, Ish Khanna   +6 more
openaire   +1 more source

New Access to 1-Deoxynojirimycin Derivatives via Azide−Alkene Cycloaddition

Organic Letters, 2008
The synthesis of 1-deoxynojirimycin (DNJ) derivatives is described from D-glucono-delta-lactone. The DNJ derivatives were obtained via a sequence that included a stereoselective intramolecular Huisgen reaction, decomposition to an aziridine, and its subsequent reaction with a nucleophile.
Ying, Zhou, Paul V, Murphy
openaire   +2 more sources

Simple and rapid determination of 1‐deoxynojirimycin in mulberry leaves

BioFactors, 2004
AbstractA simple and rapid method for determining 1‐deoxynojirimycin (DNJ), a potent glucosidase inihibitor present in mulberry leaves (Morus alba and Morus bombysis), by high performance liquid chromatography coupled to an evaporative light scattering detector (ELSD) has been developed.
Toshiyuki, Kimura, Kiyotaka, Nakagawa, Yuko, Saito, Kenji, Yamagishi, Masahiro, Suzuki, Kohji, Yamaki, Hiroshi, Shinmoto, Teruo, Miyazawa   +7 more
openaire   +2 more sources

Mulberry 1-deoxynojirimycin (DNJ): an exemplary compound for therapeutics

The Journal of Horticultural Science and Biotechnology, 2020
The Mulberry plant (Morus spp.) is known for several phytochemicals. One such phytochemical is 1-deoxyjirinomycin (DNJ), which is based, on an iminosugar.
Venkatesh Kumar Ramappa, Devika Srivastava, Prashant Singh, Umesh Kumar, Vandana Singh   +4 more
openaire   +1 more source