Results 11 to 20 of about 317,690 (321)

Neuronal Calcium Sensor-1 and Phosphatidylinositol 4-Kinase β Regulate IgE Receptor-Triggered Exocytosis in Cultured Mast Cells

Journal of Immunology, 2003
Yaara Kapp-Barnea, Semyon Melnikov, Irit Shefler, Andreas Jeromin, Ronit Sagi‐Eisenberg   +4 more
openalex   +2 more sources

A phosphoinositide switch mediates exocyst recruitment to multivesicular endosomes for exosome secretion

Nature Communications, 2023
Exosomes are secreted to the extracellular milieu when multivesicular endosomes (MVEs) dock and fuse with the plasma membrane. However, MVEs are also known to fuse with lysosomes for degradation.
Di-Ao Liu, Kai Tao, Bin Wu, Ziyan Yu, Malwina Szczepaniak, Matthew Rames, Changsong Yang, Tatyana Svitkina, Yueyao Zhu, Fengyuan Xu, Xiaolin Nan, Wei Guo   +11 more
doaj   +1 more source

Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae" [PDF]

, 2004
Signal transduction pathways are important for the cell to transduce external or internal stimuli where second messengers play an important role as mediators of the stimuli. One important group of second messengers are the phosphoinositide family present
Morales-Johansson, Helena
core   +2 more sources

Silibinin improves palmitate-induced insulin resistance in C2C12 myotubes by attenuating IRS-1/PI3K/Akt pathway inhibition [PDF]

Brazilian Journal of Medical and Biological Research, 2015
The present study investigated the effect of silibinin, the principal potential anti-inflammatory flavonoid contained in silymarin, a mixture of flavonolignans extracted from Silybum marianum seeds, on palmitate-induced insulin resistance in C2C12 ...
H.B. Li, Y.R.Y. Yang, Z.J. Mo, Y. Ding, W.J. Jiang   +4 more
doaj   +3 more sources

Polyphenol from Rosaroxburghii Tratt Fruit Ameliorates the Symptoms of Diabetes by Activating the P13K/AKT Insulin Pathway in db/db Mice

Foods, 2022
About 4% of the world’s population has type 2 diabetes mellitus (T2DM), and the available hypoglycemic drugs for treating diabetes have some side effects.
Chao Chen, Shuming Tan, Tingyuan Ren, Hua Wang, Xiaotong Dai, Hui Wang   +5 more
doaj   +1 more source

Torin 2 Derivative, NCATS-SM3710, Has Potent Multistage Antimalarial Activity through Inhibition of P. falciparum Phosphatidylinositol 4-Kinase (Pf PI4KIIIβ).

ACS Pharmacology & Translational Science, 2020
Drug resistance is a constant threat to malaria control efforts making it important to maintain a good pipeline of new drug candidates. Of particular need are compounds that also block transmission by targeting sexual stage parasites.
K. Krishnan, Peter D. Ziniel, Hao Li, Xiuli Huang, D. Hupalo, Nita D. Gombakomba, S. M. Guerrero, Thoai Dotrang, Xiao Lu, Diana Caridha, Anna R. Sternberg, E. Hughes, Wei Sun, D. Bargieri, P. Roepe, R. Sciotti, M. Wilkerson, C. Dalgard, G. Tawa, Amy Q Wang, Xin Xu, Wei Zheng, P. Sanderson, Wenwei Huang, K. Williamson   +24 more
semanticscholar   +1 more source

Bioactive lipids are altered in the kidney of chronic undernourished rats: is there any correlation with the progression of prevalent nephropathies?

Lipids in Health and Disease, 2017
Background Undernutrition during childhood leads to chronic diseases in adult life including hypertension, diabetes and chronic kidney disease. Here we explore the hypothesis that physiological alterations in the bioactive lipids pattern within kidney ...
Luzia S. Sampaio, Paulo A. da Silva, Valdilene S. Ribeiro, Carmem Castro-Chaves, Lucienne S. Lara, Adalberto Vieyra, M. Einicker-Lamas   +6 more
doaj   +1 more source

Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels [PDF]

, 2005
The relationship between receptor-induced membrane phosphatidylinositol-4'5'-bisphosphate (PIP2) hydrolysis and M-current inhibition was assessed in single-dissociated rat sympathetic neurons by simultaneous or parallel recording of membrane current and ...
Abogadie, FC, Brown, DA, Filippov, AK, Hughes, S, Marsh, SJ, Tatulian, L, Winks, JS   +6 more
core   +1 more source

Association of Factor V Secretion with Protein Kinase B Signaling in Platelets from Horses with Atypical Equine Thrombasthenia. [PDF]

, 2015
BackgroundTwo congenital bleeding diatheses have been identified in Thoroughbred horses: Glanzmann thrombasthenia (GT) and a second, novel diathesis associated with abnormal platelet function in response to collagen and thrombin stimulation.Hypothesis ...
Blevins, G, Norris, JW, Pombo, M, Shirley, E, Tablin, F   +4 more
core   +1 more source

Examining the role of insulin in the regulation of cardiovascular health [PDF]

, 2013
A substantial body of evidence has reported that insulin has direct actions on the cardiovascular system independent of its systemic effects on plasma glucose or lipids.
Salt, Ian P.
core   +1 more source