Results 31 to 40 of about 317,690 (321)

A Single Point Mutation in the Rhinovirus 2B Protein Reduces the Requirement for Phosphatidylinositol 4-Kinase Class III Beta in Viral Replication

Journal of Virology, 2018
Human rhinoviruses (RVs) are the major cause of the common cold worldwide. They cause asthmatic exacerbations and chronic obstructive pulmonary disease.
Pascal S. Roulin, Luca Murer, U. Greber
semanticscholar   +1 more source

Insulin-like growth factor-1 stimulates retinal cell proliferation via activation of multiple signaling pathways

Current Research in Neurobiology, 2023
Insulin-like growth factor-1 (IGF-1) plays critical roles in the development of the central nervous system (CNS), including the retina, regulating cell proliferation, differentiation, and survival.
Camila Saggioro de Figueiredo, Ícaro Raony, Simone Vidal Medina, Eliezer de Mello Silva, Aline Araujo dos Santos, Elizabeth Giestal-de-Araujo   +5 more
doaj  

Arabidopsis Type II Phosphatidylinositol 4-Kinase PI4Kγ5 Regulates Auxin Biosynthesis and Leaf Margin Development through Interacting with Membrane-Bound Transcription Factor ANAC078

PLoS Genetics, 2016
Normal leaf margin development is important for leaf morphogenesis and contributes to diverse leaf shapes in higher plants. We here show the crucial roles of an atypical type II phosphatidylinositol 4-kinase, PI4Kγ5, in Arabidopsis leaf margin ...
Yong Tang, Chunzao Zhao, Shutang Tan, Hong-Wei Xue   +3 more
semanticscholar   +1 more source

The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. [PDF]

, 2010
Deregulation of the phosphoinositide-3-OH kinase (PI(3)K) pathway has been implicated in numerous pathologies including cancer, diabetes, thrombosis, rheumatoid arthritis and asthma.
Alex Berndt, Benjamin T Houseman, Christian Rommel, Daniel D Le, Fabrice Gorrec, Jeffrey P Shaw, Joseph I Pacold, Kevan M Shokat, Matthias K Schwarz, Olusegun Williams, Pascale Gaillard, Pingda Ren, Roger L Williams, Simon Miller, Thomas Rückle, Wai-Ching Hon, Yi Liu   +16 more
core   +2 more sources

Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]

, 1998
The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, A.
core   +2 more sources

Activation of COUP-TFI by a Novel Diindolylmethane Derivative

Cells, 2019
Chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is an orphan receptor and member of the nuclear receptor superfamily. Among a series of methylene substituted diindolylmethanes (C-DIMs) containing substituted phenyl and ...
Kyungsil Yoon, Chien-Cheng Chen, Asuka A. Orr, Patricia N. Barreto, Phanourios Tamamis, Stephen Safe   +5 more
doaj   +1 more source

Hepatitis C virus NS5A protein cooperates with phosphatidylinositol 4-kinase IIIα to induce mitochondrial fragmentation

Scientific Reports, 2016
Hepatitis C virus (HCV) has long been observed to take advantage of the host mitochondria to support viral replication and assembly. The HCV core protein has been implicated to fragment host mitochondria.
Gavin Ka Yu Siu, Fan Zhou, M. Yu, Leiliang Zhang, Tuanlao Wang, Yongheng Liang, Yangchao Chen, H. Chan, Sidney Yu   +8 more
semanticscholar   +1 more source

Targeting phosphoinositide 3-kinase (PI3K) in head and neck squamous cell carcinoma (HNSCC). [PDF]

, 2018
The landscape of head and neck squamous cell carcinoma (HNSCC) has been changing rapidly due to growing proportion of HPV-related disease and development of new therapeutic agents.
Jung, Kyungsuk, Kang, Hyunseok, Mehra, Ranee   +2 more
core   +2 more sources

(-)-Epicatechin and β-glucan from highland barley grain modulated glucose metabolism and showed synergistic effect via Akt pathway

Journal of Functional Foods, 2021
In this study, (-)epicatechin (EC) and β-glucan (BG) were identified as the active compounds in highland barley grain that modulated glucose metabolism.
Ze-Hua Liu, Bo Li
doaj  

Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking.

Gastroenterology, 2014
BACKGROUND & AIMS Positive-sense RNA viruses remodel intracellular membranes to generate specialized membrane compartments for viral replication. Several RNA viruses, including poliovirus and hepatitis C virus (HCV), require phosphatidylinositol (PI) 4 ...
Hongliang Wang, J. W. Perry, A. Lauring, P. Neddermann, R. de Francesco, Andrew W. Tai   +5 more
semanticscholar   +1 more source