Results 141 to 150 of about 18,744,545 (170)

Synaptic density is associated with cognitive performance in Alzheimer’s disease: A PET imaging study with [11C]UCB‐J

Alzheimer's & Dementia, 2021
AbstractBackgroundFor 30 years synapse loss has been referred to as the major pathological correlate of cognitive impairment in Alzheimer’s disease (AD). However, this statement is based on remarkably few patients studied by autopsy or biopsy in limited brain regions, largely at the moderate to severe stages of disease.
Christopher H. van Dyck, Emily Sharp, Ryan S. O'Dell, Emmie R. Banks, Hugh H. Bartlett, Ming‐Kai Chen, Mika Naganawa, Takuya Toyonaga, Joanna E. Harris, Gessica S. Ni, Wenzhen Zhao, Nabeel B. Nabulsi, Brent C. Vander Wyk, Yiyun Huang, Amy F. T. Arnsten, Richard E. Carson, Adam P. Mecca   +16 more
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Synaptic density is associated with cognitive performance in early Alzheimer's disease: a PET imaging study with [11C]UCB-J

The American Journal of Geriatric Psychiatry, 2021
Introduction For 30 years synapse loss has been referred to as the major pathological correlate of cognitive impairment in Alzheimer's disease (AD; Terry, et al. 1991; DeKosky and Scheff. 1990). However, this statement is based on remarkably few patients studied by autopsy or biopsy in limited brain regions, largely at the moderate to severe stages of
Emily Sharp, Ryan O'Dell, Emmie Banks, Hugh Bartlett, Ming-Kai Chen, Mika Naganawa, Takuya Toyonaga, Joanna Harris, Gessica Ni, Wenzhen Zhao, Nabeel Nabulsi, Brent Vander Wyk, Yiyun Huang, Amy Arnsten, Richard Carson, Adam Mecca, Christopher van Dyck   +16 more
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226  Reduced synaptic density in progressive supranuclear palsy and corticobasal syndrome, revealed by [11C]UCB-J PET

Journal of Neurology, Neurosurgery & Psychiatry, 2022
Synaptic loss is prominent in several human neurodegenerative diseases. We tested the hypothesis that synaptic density is reduced by the primary tauopathies of progressive supranuclear palsy (PSP) and cor- ticobasal syndrome (CBS). Thirty-three participants (10 CBS, 10 PSP, and thirteen age-/sex-/education- matched controls) underwent clinical and ...
Negin Holland, P Simon Jones, George Savulich, Young T Hong, Tim Fryer, Roido Manavaki, Selena Milicevic-Sephton, Franklin I Aigbirhio, John O’Brien, James B Rowe   +9 more
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11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults

Molecular Psychiatry
The neural bases of autism are poorly understood at the molecular level, but evidence from animal models, genetics, post-mortem studies, and single-gene disorders implicate synaptopathology. Here, we use positron emission tomography (PET) to assess the density of synapses with synaptic vesicle glycoprotein 2A (SV2A) in autistic adults using 11C-UCB-J ...
David Matuskey, Yanghong Yang, Mika Naganawa, Sheida Koohsari, Takuya Toyonaga, Paul Gravel, Brian Pittman, Kristen Torres, Lauren Pisani, Caroline Finn, Sophie Cramer-Benjamin, Nicole Herman, Lindsey H. Rosenthal, Cassandra J. Franke, Bridget M. Walicki, Irina Esterlis, Patrick Skosnik, Rajiv Radhakrishnan, Julie M. Wolf, Nabeel Nabulsi, Jim Ropchan, Yiyun Huang, Richard E. Carson, Adam J. Naples, James C. McPartland   +24 more
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A new phenylstannyl precursor for synthesizing [11C]UCB-J

Nuclear Medicine and Biology, 2023
Wakana Mori, Nobuki Nengaki, Hideki Ishii, Katsushi Kumata, Masayuki Fujinaga, Ming-Rong Zhang   +5 more
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Long term experience in [11C]UCB-J production in Turku PET Centre

Nuclear Medicine and Biology, 2022
Anna Krzyczmonik, Saara Wahlroos, Semi Helin, Anna Kirjavainen, Olof Solin   +4 more
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Spontaneous brain activity and synaptic density in schizophrenia: a combined [11C]UCB-J PET and fMRI study

Abstract Schizophrenia is associated with altered Amplitude of Low Frequency Fluctuations (ALFF), a functional Magnetic Resonance Imaging (fMRI) measure of spontaneous brain activity at rest. ALFF in healthy controls has been linked with presynaptic density levels measured by [11C]UCB-J positron emission tomography (PET).
Ekaterina Shatalina, Ellis Chika Onwordi, Thomas Whitehurst, Alexander Whittington, Ayla Mansur, Atheeshaan Arumuham, Tiago Reis Marques, Roger N. Gunn, Sridhar Natesan, Eugenii A. Rabiner, Matthew B. Wall, Oliver D Howes   +11 more
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Evaluating infusion methods and simplified quantification of synaptic density in vivo with [11C]UCB-J and [18F]SynVesT-1 PET.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023
For some positron emission tomography studies, radiotracer is administered as bolus plus continuous infusion (B/I) to achieve a state of equilibrium. This approach can reduce scanning time and simplify data analysis; however, the method must be validated and optimized for each tracer. This study aimed to validate a B/I method for in vivo quantification
Ruth H, Asch, Mika, Naganawa, Nabeel, Nabulsi, Yiyun, Huan, Irina, Esterlis, Richard E, Carson   +5 more
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A Practical Production of Clinical Interesting Radiotracer [11C]UCB-J

Nuclear Medicine and Biology, 2023
Hari Akula, Bao Hu, Gino Giacoio, Yiu-Fung Mui, Qing Feng, Mark Slifstein, Ramin Parsey, Wenchao Qu   +7 more
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Quantitative monitoring of ketamine’s impact on synaptic density using 11C-UCB-J PET imaging in the corticosterone mouse model of anxiety/depression

Molecular Psychiatry
Ketamine was shown to promote synaptogenesis, which is thought to account for its antidepressant effects through the restoration of lost synaptic connections observed in depression. PET imaging using 11C-UCB-J, a radiotracer targeting the synaptic vesicle protein 2 A (SV2A), was investigated as a translational method to monitor ketamine-induced changes
Corvo, Cassandre, Goutal, Sébastien, Mendez-David, Indira, Leterrier, Sarah, Caille, Fabien, Saba, Wadad, Colle, Romain, Corruble, Emmanuelle, Lebon, Vincent, Bottlaender, Michel, Leroy, Claire, J. David, Denis, Tournier, Nicolas   +12 more
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