Results 21 to 30 of about 618 (145)
Identification of subunits of the 650 kDa 12(S)-HETE binding complex in carcinoma cells
Journal of Lipid Research, 1998 Cytosol and nuclei of Lewis lung carcinoma (LLC) cells contain high affinity binding sites specific for the arachidonic acid metabolite 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12(S)-HETE). In this report we present evidence that the cytosolic 12(S)
Helena Herbertsson +4 more
doaj +1 more source
Antiplatelet Effect of NQ12: a Possible Mechanism Through the Arachidonic Acid Cascade
Journal of Pharmacological Sciences, 2007 NQ12, an antithrombotic agent, has been reported to display a potent antiplatelet activity. This study was undertaken to reveal the effect of NQ12 on rabbit platelet aggregation and signal transduction involved in the arachidonic acid (AA) cascade.
Yong-Ri Jin +8 more
doaj +1 more source
Polyunsaturated fatty acid-derived lipid mediators and T cell function [PDF]
, 2014 Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY) .
Marelli-Berg, F +3 more
core +3 more sources
Psoriasis—An Immunological Disease [PDF]
, 1996 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111129/1/jde02714 ...
Alroy +26 more
core +1 more source
Natural Products for Antithrombosis
Evidence-Based Complementary and Alternative Medicine, Volume 2015, Issue 1, 2015., 2015 Thrombosis is considered to be closely related to several diseases such as atherosclerosis, ischemic heart disease and stroke, as well as rheumatoid arthritis, hyperuricemia, and various inflammatory conditions. More and more studies have been focused on understanding the mechanism of molecular and cellular basis of thrombus formation as well as ...
Cen Chen +6 more
wiley +1 more source
Journal of Investigative Dermatology, 1989 We have developed an assay to study the effect of drugs on the proliferation of neonatal human skin-derived keratinocytes in vitro. Expanding populations of neonatal keratinocytes were cultured in low concentrations (0.5%) of fetal calf serum for up to 12 d.
Otto, William R. +4 more
openaire +2 more sources
Blood Level Omega‐3 Fatty Acids as Risk Determinant Molecular Biomarker for Prostate Cancer
Prostate Cancer, Volume 2013, Issue 1, 2013., 2013 Previous researches involving dietary methods have shown conflicting findings. Authors sought to assess the association of prostate cancer risk with blood levels of omega‐3 polyunsaturated fatty acids (n‐3 PUFA) through a meta‐analysis of human epidemiological studies in available online databases (July, 2012).
Mishell Kris Sorongon-Legaspi +4 more
wiley +1 more source
The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier [PDF]
, 2014 This review covers the background to discovery of the two key lipoxygenases (LOX) involved in epidermal barrier function, 12R-LOX and eLOX3, and our current views on their functioning.
Brash, Alan R. +4 more
core +1 more source
Stimulation of Phospholipase A2 by Toxic Main Group Heavy Metals: Partly Dependent on G‐proteins?
Metal-Based Drugs, Volume 2, Issue 2, Page 91-98, 1995., 1994 Organometals induce platelet aggregation and inorganic metal ions such as Cd2+ or Pb2+ sensitise human blood platelets to aggregating agents and this action is associated with the liberation of arachidonic acid and eicosanoid formation. The same mechanism is observed using human leukaemia cells (HL‐60) when treated with MeHgCl or Et3PbCl .
H. F. Krug
wiley +1 more source
Journal of Investigative Dermatology, 1980 Soluble guanylate cyclase activity was measured in normal and psoriatic human epidermis. The specific activity of guanylate cyclase was determined to be increased 10-fold and 3-fold in involved and uninvolved epidermis of psoriatics, respectively, compared to normal epidermis.
Cantieri, John S. +2 more
openaire +2 more sources