High Sugar Induced RCC2 Lactylation Drives Breast Cancer Tumorigenicity Through Upregulating MAD2L1
Advanced Science, EarlyView.This study finds that KAT2A mediates the lactylation modification of the non‐histone protein RCC2 at K124, facilitating the recruitment of free SERBP1 and aiding in the formation of the initial SERBP1‐MAD2L1 complex. SERBP1 enhances the stability of MAD2L1 mRNA and promotes cellular proliferation.
Bowen Zheng +11 more
wiley +1 more source
CRISPR/Cas9-based depletion of 16S ribosomal RNA improves library complexity of single-cell RNA-sequencing in planarians. [PDF]
BMC Genomics, 2023 Wang KT, Adler CE.
europepmc +1 more source
Collection of small subunit (16S- and 16S-like) ribosomal RNA structures: 1994 [PDF]
Nucleic Acids Research, 1994 A collection of diverse 16S and 16S-like rRNA secondary structure diagrams are available. This set of rRNAs contains representative structures from all of the major phylogenetic groupings--Archaea, (eu)Bacteria, and the nucleus, mitochondrion, and chloroplast of Eucarya.
openaire +3 more sources
Advanced Science, EarlyView.The biosynthetic mechanism of novel natural tetramic acid S‐TeA in Alternaria alternata is elucidated. Threonine acts as a precursor for 2‐amino‐3‐methylhexanoic acid (AMHA) synthesis via eight key enzymes from the branched‐chain amino acid biosynthetic pathway in the mitochondrion, wherein three unique enzymes (IPMS, IPMDH, and ISMD) play critical ...
He Wang +9 more
wiley +1 more source
One Health Spread of 16S Ribosomal RNA Methyltransferase-Harboring Gram-Negative Bacterial Genomes: An Overview of the Americas. [PDF]
Pathogens, 2023 Sellera FP +2 more
europepmc +1 more source
Advanced Science, EarlyView.In people with overweight or obesity, regular exercise even without weight loss or vitamin D supplementation completely prevents the usual winter decline in the vitamin D metabolite that maintains health at a cellular level, 1,25(OH)2D3, and ameliorates the decline in the vitamin D status marker 25(OH)D.
Oliver J. Perkin +11 more
wiley +1 more source
30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC. [PDF]
Proc Natl Acad Sci U S A, 2023 Srinivas P +6 more
europepmc +1 more source
Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair
Advanced Science, EarlyView.CircGLIS3(2), a circRNA transiently upregulated in dermal fibroblasts during acute wound healing, is induced by IL‐1α and TGF‐β. Its RNA activates fibroblasts into matrix‐secreting cells, while its encoded protein enhances proliferation. The RNA stabilizes PCOLCE, and the protein interacts with BTF3, collectively accelerating wound repair. Abstract The
Guanglin Niu +20 more
wiley +1 more source
Novel and Efficient Method for Diagnosing Infective Endocarditis Using 16S Ribosomal RNA Gene Amplicon Sequence. [PDF]
JACC Case Rep, 2023 Kataoka A +14 more
europepmc +1 more source
Advanced Science, EarlyView.The gut microbiome is a potential target for treating cardiovascular disease. It is found that prophylactic administration of Flavonifractor plautii or its metabolite desaminotyrosine (DAT) exerts pleiotropic cardioprotective effects via promoting cardiomyocyte survival and attenuating cardiac inflammation against myocardial ischemia/reperfusion (I/R ...
Heng Du +21 more
wiley +1 more source