Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020 The resistance of such strains as Staphylococcus aureus, Escherichia coli extends to many antimicrobial drugs. This problem can be solved by searching for new drugs with high bactericidal and antifungal action.
Ye. O. Karpun, N. M. Polishchuk
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Angewandte Chemie, EarlyView.Die geminale Difunktionalisierung leicht verfügbarer Bausteine ermöglicht einen schnellen Zugang zu molekularer Komplexität. Diese Arbeit stellt eine Strategie vor, um zwei unterschiedliche funktionelle Gruppen an einem Carbonylkohlenstoff zu installieren, indem dieser in eine Donor–Donor‐Diazo‐Verbindung überführt wird. Die Methode ist sowohl im Batch‐
Vincent George +13 more
wiley +1 more source
Current research trends of 1,2,4-triazole derivatives biological activity (literature review)
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktikiderivatives 1,2,4-triazole, biological activity,
I. M. Bilai +3 more
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Direct evidence of a blocking heavy atom effect on the water-assisted fluorescence enhancement detection of Hg²⁺ based on a ratiometric chemosensor [PDF]
, 2014 At the current stage of chemosensor chemistry, the critical question now is whether the heavy atom effect caused by HTM ions can be blocked or avoided. In the present work, we provide unequivocal evidence to confirm that the heavy atom effect of Hg²⁺ is ...
Ni, Xin-Long +3 more
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Synthesis of 3,5-di-(4-pyridyl)-1H-1,2,4-triazole
Molbank, 2008 n ...
Guang Yang, Li-Li Liu
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Analyzing the Binding of Co(II)-specific Inhibitors to the Methionyl Aminopeptidases from \u3cem\u3eEscherichia coli\u3c/em\u3e and \u3cem\u3ePyrococcus furiosus\u3c/em\u3e [PDF]
, 2009 Methionine aminopeptidases (MetAPs) represent a unique class of protease that is capable of the hydrolytic removal of an N-terminal methionine residue from nascent polypeptide chains.
Bennett, Brian +4 more
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Predicting Solid-State Heats of Formation of Newly Synthesized Polynitrogen Materials by Using Quantum Mechanical Calculations [PDF]
, 2008 We present density functional theory level predictions and analysis of the basic properties of newly synthesized high-nitrogen compounds together with 3,6-bis(2H-tetrazol-5-yl)-1,2,4,5-tetrazine (BTT) and 3,3′-azobis(6-amino-1,2,4,5-tetrazine) (DAAT ...
Abou-Rachid, H. +5 more
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A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase
Angewandte Chemie International Edition, EarlyView.The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne +22 more
wiley +1 more source
1,2,3-triazolo[4,5-h]quinolines: III: preparation and antimicrobial evaluation of 4-ethyl-4,7-dihydro-1(2)-R-1(2)H triazolo[4,5-h]quinolin-7-one-6-carboxylic acids as anti-infectives of the urinary tract [PDF]
, 1992 Some 4-ethyl-1(2)-R-1(2)H-4,7-dihydro-triazolo[4,5-h]-quinolin-7-one-6- carboxylic acids were prepared as novel analogues of oxolinic acid, in order to discover the influence of the annelation position of the triazole ring on the antimicrobial activity ...
Carta, Antonio +4 more
core
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017 Introduction. Heterocyclic system of 1,2,4-triazole is interesting and has a popularity among scientists around the world every year. Most attention today is attracted to the compounds formed by a combination of 1,2,4-triazole and various structural ...
D. M. Danilchenko +2 more
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