Results 121 to 130 of about 5,282,956 (341)

Antidepressant Activity of Some Novel 1, 2, 4 Triazole Substituted Quinazoline Derivatives

International Journal of Pharmaceutical Chemistry and Analysis, 2016
Introduction: Quinazoline is an important moiety found natural and used for their biological activity, quinazoline always attract scientist due to its broad therapeutic value. In the present research article we prepared a series of fifteen compound by conjugating to prominent therapeutic active moiety to produce synergistic effect to mimic the ...
Narendra Joshi, Anju Goyal
openaire   +1 more source

Impact of glucuronide interferences on therapeutic drug monitoring of posaconazole by tandem mass spectrometry [PDF]

, 2010
Background: Posaconazole is a novel antifungal drug for oral application intended especially for therapy of invasive mycoses. Due to variable gastrointestinal absorption, adverse side effects, and suspected drug-drug interactions, therapeutic drug ...
Burghardt, Stephan, Krueger, Ralf, Lackner, Karl J., Vogelsberger, Rita, Vogeser, Michael   +4 more
core   +1 more source

SÍNTESE E AVALIAÇÃO DA ATIVIDADE CITOTÓXICA DE DERIVADOS DO EUGENOL CONTENDO NÚCLEOS 1,2,3-TRIAZÓLICOS

Química Nova
Eugenol is an aromatic compound found in several plant species. It presents important biological activities including cytotoxicity. In this paper, it is described the synthesis and the evaluation of the cytotoxic activity of eugenol derivatives bearing 1,
Poliana Aparecida Rodrigues Gazolla, Róbson Ricardo Teixeira, Adalberto Manoel da Silva, Boniek Gontijo Vaz, Géssica Adriana Vasconcelos, Raoni Pais Siqueira, Victor Hugo Sousa Gonçalves, Higor Sette Pereira, Gustavo Costa Bressan   +8 more
doaj   +1 more source

Synthesis, physical-chemical properties and further transformation of 5-(quinoline-2-yl, 2-hydroxyquinoline-4-yl)-4-R-2,4-dyhydro-3Н-1,2,4-triazole-3-thiones

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016
The aim of this work was the synthesis of new highly effective and low-toxic substances in a series of 5-(quinoline-2-yl, 2-hydroxyquinoline-4-yl)-4-R1-2,4-dyhydro-3Н-1,2,4-triazole-3-thiones and its derivatives, and also establishment of physical ...
T. M. Kaplaushenko
doaj   +1 more source

Chemical Structure and Herbicidal Activity of 1, 2, 4-Triazole-carboxamide Derivatives.

Journal of Weed Science and Technology, 1999
新規な1,2,4-トリアゾールカルボキサミド誘導体について, タイヌビエに対する除草活性と移植イネに対する安全性を指標として, 構造と活性を検討した。1. 雑草発生前処理高いタイヌビエ除草活性と移植イネに対する安全性を保有するには, ベンゼン環の2位と6位が低級アルキル基や塩素原子で置換されていることが必要で, とくに2,6-ジメチル置換体, 2-メチル-6-エチル置換体, 2-メチル-6-塩素置換体および2,4,6-トリメチル置換体が, 優れた除草活性とイネ安全性を示した。カルバモイル基の置換様式は, N,N-ジエチルカルバモイル体およびN-エチル, N-プロピカルバモイル体が高活性に寄与し, アルキル基がメチルあるいはブチルでは劣った。イネに対してはいずれも高い安全性を示した ...
Mitsuru Kanzaki, Masaki Takeuchi, Norio Shirakawa   +2 more
openaire   +2 more sources

Designer Reagents for Mass Spectrometry-Based Proteomics: Clickable Cross-Linkers for Elucidation of Protein Structures and Interactions [PDF]

, 2012
We present novel homobifunctional amine-reactive clickable cross-linkers (CXLs) for investigation of three-dimensional protein structures and protein–protein interactions (PPIs).
Agnew, Heather D., Beauchamp, J. L., Czerwieniec, Gregg, Deshaies, Raymond J., Graham, Robert L. J., Heath, James R., Hess, Sonja, Lee, J. Eugene, Loo, Joseph A., Smith, Geoffrey T., Sohn, Chang Ho, Sweredoski, Michael J.   +11 more
core   +2 more sources

Geminal Difunctionalization of Ketones via C─S Bond Insertion of Photogenerated Donor–Donor Diazo Compounds

Angewandte Chemie International Edition, EarlyView.
Geminal difunctionalization of readily available building blocks provides rapid access to molecular complexity. This work introduces a strategy for installing two distinct functional groups on a carbonyl carbon by transforming it into a donor–donor diazo compound, enabling both batch and flow applications with broad solvent compatibility.
Vincent George, Aryaman Pattanaik, Daniel Maddox, Lukas M. Sigmund, Giovanna Mejia, Sara Pahlén, Simon O. Angerer, Maria Schmoll, Lisa Marie Schneider, Nidhal Selmi, Mikhail Kabeshov, Giulia Bergonzini, Julia Rehbein, Burkhard König   +13 more
wiley   +1 more source

3-Aryl Substituted Triazole Derivatives as New and Effective Corrosion Inhibitors for Mild Steel in Hydrochloric Acid Solution

International Journal of Electrochemical Science, 2012
The corrosion inhibition properties of three triazoles derivatives namely 4-amino-5-phenyl-4H-1, 2, 4,-triazole-3-thiol (APTT), 4-amino-5-(2-hydroxy) phenyl-4H-1, 2, 4,-triazole-3-thiol, (AHPTT), 4-amino-5-styryl-4H-1, 2, 4,-triazole-3-thiol, (ASTT) on ...
M.A. Quraishi, Sudheer, K.R. Ansari, Eno E. Ebenso   +3 more
doaj   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

Shedding Light on Synthetic Autocatalysis: From Conventional Closed‐Shell Chemistries to Overlooked Open‐Shell Occurrences

Chemistry – A European Journal, EarlyView.
Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley   +1 more source