Results 11 to 20 of about 5,282,956 (341)

Synthesis, docking study, and structure activity relationship of novel anti-tumor 1, 2, 4 triazole derivatives incorporating 2-(2, 3- dimethyl aminobenzoic acid) moiety [PDF]

Pharmacia, 2022
A series of 1,2,4 triazole derivatives (H7-12) have been synthesized by reacting an excess of hydrazine hydrate with carbothioamide derivatives (H1-6).
Hiba Alsaad, Ammar Kubba, Lubna H. Tahtamouni, Ali H. Hamzah   +3 more
doaj   +3 more sources

Novel 1, 2, 4‐Triazoles as Antifungal Agents

BioMed Research International, 2022
The development of innovative antifungal agents is essential. Some fungicidal agents are no longer effective due to resistance development, various side effects, and high toxicity. Therefore, the synthesis and development of some new antifungal agents are necessary. 1,2,4‐Triazole is one of the most essential pharmacophore systems between five‐membered
Zahra Kazeminejad, Mahrokh Marzi, Abolfazl Shiroudi, Seyed Amin Kouhpayeh, Mojtaba Farjam, Elham Zarenezhad   +5 more
openaire   +3 more sources

Insights into Corrosion Inhibition Behavior of a 5-Mercapto-1, 2, 4-Triazole Derivative for Mild Steel in Hydrochloric Acid Solution: Experimental and DFT Studies

Lubricants, 2021
A triazole heterocyclic compound namely 3-(4-ethyl-5-mercapto-1, 2, 4-triazol-3-yl)-1-phenylpropanone (EMTP) was examined for its corrosion protection of mild steel (MS) against 1 M hydrochloric acid medium using gravimetric techniques.
Israa Abd Alkadir Aziz, I. A. Annon, M. Abdulkareem, M. Hanoon, Mohammed H. Alkaabi, L. Shaker, A. Alamiery, Wan Nor Roslam Wan Isahak, M. Takriff   +8 more
semanticscholar   +1 more source

An in silico investigation of 1,2,4-triazole derivatives as potential antioxidant agents using molecular docking, MD simulations, MM-PBSA free energy calculations and ADME predictions [PDF]

Pharmacia, 2023
In this study, we’ve performed computable studies of previously synthesized 1,2,4-triazole derivatives by virtual screening due to antioxidant activity. Six enzymes responsible for regulating oxidative stress were selected as key targets. One hundred and
Yevhen Karpun, Sergiy Fedotov, Anastasiia Khilkovets, Yuriy Karpenko, Volodymyr Parchenko, Yana Klochkova, Yuliia Bila, Iryna Lukina, Natalia Nahorna, Volodymyr Nahornyi   +9 more
doaj   +3 more sources

Synthesis, characterization, and antimicrobial evaluation of new Schiff bases derived from vanillic acid conjugated to heterocyclic 4H-1,2,4-triazole-3-thiol

Pharmacia, 2023
A multistep synthesis was established for the preparation of a new vanillic acid-1, 2, 4-1triazole-3-thiol conjugate (4). Finally, several aromatized aldehydes reacted with compound (4) to produce Schiff bases derivatives (5–11).
Noor Ali Hussein Sabzi, M. M. Al-Mudhafar   +1 more
semanticscholar   +1 more source

Synthesis of 2-(3-chloro-4-nitro-1-benzothien-2-yl)-1,3,4-oxadiazole-1,3,4-thiadiazole and 5-(3-chloro-4-nitro-1-benzothien-2-yl)-4H-1,2,4-triazole-3-thiol [PDF]

مجلة التربية والعلم, 2010
In this paper the synthesis of some substituted 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole is reported. 3-chloro-4-nitro-2-chloro carbonyl benzo [b] thiophene(1) was synthesized from 2-nitrocinnamic acid by its reaction with thionyl chloride ...
Khalid M. Daoud, Amal N. Ali, Amina A. Ahmed   +2 more
doaj   +1 more source

Analysis of biological properties of 1,2,4-triazole-containing compounds (literature review)

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022
In the latest conditions of development and formation of the pharmaceutical industry, the introduction of new synthetic medicines requires continuous monitoring of the quality and safety of their use.
A. V. Khilkovets, V. V. Parchenko
doaj   +1 more source

In silico evaluation of the pharmacodynamic component of the interaction of S-alkyl derivatives of 5-methyl-4-(p-tolyl)-1,2,4-triazole-3-thiol with some biological targets

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2023
Derivatives of 1,2,4-triazole open wide opportunities for modern and progressive scientists in the development of innovative medicines. These compounds are known for their variability and structural flexibility, which allows scientists to experiment and ...
O. I. Panasenko, V. M. Odyntsova, A. S. Hotsulia   +2 more
doaj   +1 more source

Synthesis and Study of Some fused Substituted 1,3,4-Thiadiazoles and 1,2,4-Triazoles from 4-Chloro- phenoxy acetic acid and 2,4-dichlorophenoxy acetic acid [PDF]

مجلة التربية والعلم, 2020
In this work the synthesis of some substituted 1,2,4-triazoles and five ring system's reported. 2-(4-Chlorophenoxy) acetic acid (S1) was synthesis from corresponding substituted phenol by its reaction with chloroacetic acid in sodium hydroxide solution ...
Mudhar Othman
doaj   +1 more source

Effect of 4-benzylidenamino-5-phenyl-4Н-1,2,4-triazole-3-thiones and salts of 2-(4-amino-5-phenyl-4Н-1,2,4-triazole-3-ylthio)acetic acid on central component of nociceptive system

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016
Aim. To study the effect of 4-benzylideneamino-5-phenyl-4H-1,2,4-triazole-3-thiones and salts of 2-(4-amino-5-phenyl-4H-1,2,4-triazole-3-yltio)acetic acid on central component of nociceptive system on condition of thermal stimulation of limbs of rats ...
Ye. S. Pruhlo
doaj   +1 more source